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regenerasi:
Apakah salamander hold the key ?
Rahasia
bagaimana Salamander berhasil menumbuhkan kembali bagian-bagian tubuh .... .... dibongkar
oleh para peneliti untuk menerapkannya ke manusia. Untuk pertama kalinya, para
peneliti telah menemukan bahwa 'ERK pathway' harus selalu aktif untuk sel
salamander harus memprogram ulang, dan karenanya dapat memberikan kontribusi
untuk regenerasi bagian tubuh yang berbeda..........
Limb regeneration: Do salamanders hold the key?
Date:
June 19,
2014
Source:
University College London
Summary:
The secret of how salamanders
successfully regrow body parts is being unravelled by researchers in a bid to
apply it to humans. For the first time, researchers have found that the 'ERK
pathway' must be constantly active for salamander cells to be reprogrammed, and
hence able to contribute to the regeneration of different body parts.
..................................
The secret of how salamanders successfully regrow body parts
is being unravelled by UCL researchers in a bid to apply it to humans.
For the
first time, researchers have found that the 'ERK pathway' must be constantly
active for salamander cells to be reprogrammed, and hence able to contribute to
the regeneration of different body parts.
The team
identified a key difference between the activity of this pathway in salamanders
and mammals, which helps us to understand why humans can't regrow limbs and
sheds light on how regeneration of human cells can be improved.
The study
published in Stem Cell Reports today, demonstrates that the ERK pathway
is not fully active in mammalian cells, but when forced to be constantly
active, gives the cells more potential for reprogramming and regeneration. This
could help researchers better understand diseases and design new therapies.
Lead
researcher on the study, Dr Max Yun (UCL Institute of Structural and Molecular
Biology) said: "While humans have limited regenerative abilities, other
organisms, such as the salamander, are able to regenerate an impressive
repertoire of complex structures including parts of their hearts, eyes, spinal
cord, tails, and they are the only adult vertebrates able to regenerate full
limbs.
We're
thrilled to have found a critical molecular pathway, the ERK pathway, that
determines whether an adult cell is able to be reprogrammed and help the
regeneration processes. Manipulating this mechanism could contribute to
therapies directed at enhancing regenerative potential of human cells."
The ERK
pathway is a way for proteins to communicate a signal from the surface of a
cell to the nucleus which contains the cell's genetic material. Further
research will focus on understanding how this important pathway is regulated
during limb regeneration, and which other molecules are involved in the
process.
Story
Source:
The above
story is based on materials provided by University College London. Note: Materials may be edited
for content and length.
Journal
Reference:
- Maximina H. Yun, Phillip B. Gates, Jeremy P. Brockes. Sustained ERK Activation Underlies Reprogramming in Regeneration-Competent Salamander Cells and Distinguishes Them from Their Mammalian Counterparts. Stem Cell Reports, 2014; DOI: 10.1016/j.stemcr.2014.05.009
