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Diet tinggi
lemak, obesitas selama kehamilan merugikan stem sel dalam perkembangan fetus
Dokter-ilmuwan mengungkapkan diet tinggi lemak dan obesitas selama
kehamilan membahayakan pembentuk darah, atau hematopoietik, sistem sel induk
dalam hati janin yang bertanggung jawab untuk menciptakan dan mempertahankan
darah seumur hidup dan fungsi sistem kekebalan tubuh.....read more
High-fat diet,
obesity during pregnancy harms stem cells in developing fetus
Date:
December 24, 2014
Source:
Oregon Health &
Science University
Summary:
Physician-scientists
reveal a high-fat diet and obesity during pregnancy compromise the
blood-forming, or hematopoietic, stem cell system in the fetal liver
responsible for creating and sustaining lifelong blood and immune system
function.
........................
physician-scientists at
OHSU Doernbecher Children's Hospital reveal a high-fat diet and obesity during
pregnancy compromise the blood-forming, or hematopoietic, stem cell system in
the fetal liver responsible for creating and sustaining lifelong blood and
immune system function.
The life-long burden of a western-style diet on the heart and circulatory
system have long been appreciated. However, prior to this study, no one had
considered whether the developing blood stem cells might be similarly
vulnerable to prenatal high-fat diet and/or maternal obesity. The findings are
published in the journal Molecular Metabolism.
"Our results offer a model for testing whether the effects of a
high-fat diet and obesity can be repaired through dietary intervention, a key
question when extrapolating this data to human populations," said Daniel
L. Marks, M.D., Ph.D., co-investigator and professor of pediatric endocrinology
in the OHSU School of Medicine and Papé Family Pediatric Research Institute at
OHSU Doernbecher Children's Hospital.
Several years ago, Marks and colleagues developed a mouse model that
closely mimics the high-fat, high-simple-sugar diet currently consumed by many
young women of childbearing age. Their subsequent research demonstrated that
maternal overnutrition in mice significantly reduced the size of the fetal
liver.
Armed with this information, Marks partnered with another stem cell expert,
Peter Kurre, M.D., co-investigator on the current study and professor of
pediatric oncology in the OHSU School of Medicine and the Papé Family Pediatric
Research Institute at OHSU Doernbecher Children's Hospital.
Together, they discovered that the complex changes that occur as a result
of maternal high-fat diet and obesity put significant constraints on the growth
and expansion of blood stem cells in the fetal liver, which ultimately
compromises the developing immune system.
"In light of the spreading western-style, high-fat diet and
accompanying obesity epidemic, this study highlights the need to better
understand the previous unrecognized susceptibility of the stem and progenitor
cell system," Kurre said. "These findings may provide broad context
for the rise in immune disease and allergic disposition in children."
Story Source:
The above story is based on materials provided by Oregon
Health & Science University. Note: Materials may be edited for content and length.
Journal Reference:
1. Ashley N. Kamimae-Lanning, Stephanie M.
Krasnow, Natalya A. Goloviznina, Xinxia Zhu, Quinn R. Roth-Carter, Peter R.
Levasseur, Sophia Jeng, Shannon K. McWeeney, Peter Kurre, Daniel L.
Marks. Maternal high-fat diet and obesity compromise fetal
hematopoiesis. Molecular Metabolism, 2014; DOI:10.1016/j.molmet.2014.11.001
