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Mikroskop lens free dapat mendeteksi kanker pada tingkat sel
Sebuah
mikroskop lensa-bebas dapat digunakan untuk mendeteksi adanya kanker
atau kelainan-level cell lainnya dengan akurasi yang sama dengan mikroskop optic
yang lebih besar dan lebih mahal , telah dikembangkan oleh para peneliti.
Penemuan ini bisa menyebabkan teknologi portabel lebih murah dan untuk melakukan pemeriksaan umum jaringan,
darah dan spesimen biomedis lainnya. Ini mungkin terbukti sangat berguna di
daerah terpencil dan dalam kasus di mana sejumlah besar sampel harus diperiksa
dengan cepat............
.................................
Lens-free microscope can detect cancer at cellular level
Date:
December 17, 2014
Source:
University of California - Los Angeles
Summary:
A lens-free microscope that can be used to detect the presence of cancer or
other cell-level abnormalities with the same accuracy as larger and more
expensive optical microscopes, has been developed by researchers. The invention
could lead to less expensive and more portable technology for performing common
examinations of tissue, blood and other biomedical specimens. It may prove
especially useful in remote areas and in cases where large numbers of samples
need to be examined quickly.
.........................
ucLA researchers have
developed a lens-free microscope that can be used to detect the presence of
cancer or other cell-level abnormalities with the same accuracy as larger and
more expensive optical microscopes.
The invention could lead to less expensive and more portable technology for
performing common examinations of tissue, blood and other biomedical specimens.
It may prove especially useful in remote areas and in cases where large numbers
of samples need to be examined quickly.
The microscope is the latest in a series of computational imaging and
diagnostic devices developed in the lab of Aydogan Ozcan, the Chancellor's
Professor of Electrical Engineering and Bioengineering at the UCLA Henry
Samueli School of Engineering and Applied Science and a Howard Hughes Medical
Institute professor. Ozcan's lab has previously developed custom-designed
smartphone attachments and apps that enable quick analysis of food samples for
allergens, water samples for heavy metals and bacteria, cell counts in blood
samples, and the use of Google Glass to process the results of medical
diagnostic tests.
The latest invention is the first lens-free microscope that can be used for
high-throughput 3-D tissue imaging -- an important need in the study of
disease.
"This is a milestone in the work we've been doing," said Ozcan,
who also is the associate director of UCLA's California NanoSystems Institute.
"This is the first time tissue samples have been imaged in 3D using a
lens-free on-chip microscope."
The research is the cover article in Science Translational Medicine,
which is published by the American Association for the Advancement of Science.
The device works by using a laser or light-emitting-diode to illuminate a
tissue or blood sample that has been placed on a slide and inserted into the
device. A sensor array on a microchip -- the same type of chip that is used in
digital cameras, including cellphone cameras -- captures and records the
pattern of shadows created by the sample.
The device processes these patterns as a series of holograms, forming 3-D
images of the specimen and giving medical personnel a virtual depth-of-field
view. An algorithm color codes the reconstructed images, making the contrasts
in the samples more apparent than they would be in the holograms and making any
abnormalities easier to detect.
Ozcan's team tested the device using Pap smears that indicated cervical cancer,
tissue specimens containing cancerous breast cells, and blood samples
containing sickle cell anemia. In a blind test, a board-certified pathologist
analyzed sets of specimen images that had been created by the lens-free
technology and by conventional microscopes. The pathologist's diagnoses using
the lens-free microscopic images proved accurate 99 percent of the time.
Another benefit of the lens-free device is that it produces images that are
several hundred times larger in area, or field of view, than those captured by
conventional bright-field optical microscopes, which makes it possible to
process specimens more quickly.
"While mobile health care has expanded rapidly with the growth of
consumer electronics -- cellphones in particular -- pathology is still, by and
large, constrained to advanced clinical laboratory settings," Ozcan said.
"Accompanied by advances in its graphical user interface, this platform
could scale up for use in clinical, biomedical, scientific, educational and
citizen-science applications, among others."
Story Source:
The above story is based on materials provided by University
of California - Los Angeles. The original article was written by Bill Kisliuk. Note: Materials
may be edited for content and length.
Journal Reference:
1. Aydogan Ozcan et al. Wide-field
computational imaging of pathology slides using lens-free on-chip microscopy. Science
Translational Medicine, December 2014 DOI: 10.1126/scitranslmed.3009850
