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Pemeriksaan baru payudara  hampir empat kali lipat deteksi kanker payudara invasif pada wanita dengan jaringan payudara yang padat

Pencitraan Payudara Molekuler ( MBI ) adalah teknologi pencitraan tambahan yang dirancang untuk menemukan tumor yang  dapat dikaburkan oleh sekitar jaringan payudara yang padat pada mammogram . Teknik pencitraan baru  payudara  hampir empat kali lipat tingkat deteksi kanker payudara invasif pada wanita dengan jaringan payudara yang padat , menurut hasil sebuah studi ...read more

New breast exam
nearly quadruples detection of invasive breast cancers in women with dense
breast tissue

Date:

January 23, 2015

Source:

Mayo Clinic

Summary:

Molecular Breast
Imaging (MBI) is a supplemental imaging technology designed to find tumors that
would otherwise be obscured by surrounding dense breast tissue on a mammogram.
The new breast imaging technique nearly quadruples detection rates of invasive
breast cancers in women with dense breast tissue, according to the results of a
major study.

........................

A new breast imaging
technique pioneered at Mayo Clinic nearly quadruples detection rates of
invasive breast cancers in women with dense breast tissue, according to the
results of a major study published this week in the American
Journal of Roentgenology.

Molecular Breast Imaging (MBI) is a supplemental imaging technology
designed to find tumors that would otherwise be obscured by surrounding dense
breast tissue on a mammogram. Tumors and dense breast tissue can both appear
white on a mammogram, making tumors indistinguishable from background tissue in
women with dense breasts. About half of all screening-aged women have dense
breast tissue, according to Deborah Rhodes, M.D., a Mayo Clinic Breast Clinic
physician and the senior author of this study.

MBI increased the detection rate of invasive breast cancers by more than
360 percent when used in addition to regular screening mammography, according
to the study. MBI uses small, semiconductor-based gamma cameras to image the
breast following injection of a radiotracer that tumors absorb avidly. Unlike
conventional breast imaging techniques, such as mammography and ultrasound, MBI
exploits the different behavior of tumors relative to background tissue,
producing a functional image of the breast that can detect tumors not seen on
mammography.

The study, conducted at Mayo Clinic, included 1,585 women with
heterogeneously or extremely dense breasts who underwent an MBI exam at the
time of their screening mammogram.

·        
Of these women, 21 were diagnosed with cancer -- five through mammography
alone (24 percent or 3.2 cancers per 1,000 women) and 19 with mammography plus
MBI (91 percent or 12 cancers per 1,000 women).

·        
Particularly notable was the four-fold increase in detection of invasive
cancers (1.9 invasive cancers per 1,000 women with mammography and 8.8 per
1,000 women with mammography plus MBI). Detection rates for noninvasive cancers
were not significantly different.

·        
The risk of incurring an unnecessary biopsy because of a false positive
exam increased in this study, from 1 in 100 women with mammography to 4 in 100
women with mammography plus MBI. (By comparison, recent studies have shown that
alternative supplemental screening techniques, such as ultrasound and MRI,
generate about eight additional unnecessary biopsies per 100 women.)

"The finding that MBI substantially increases detection rates of
invasive cancers in dense breasts without an unacceptably high increase in
false positive findings has important implications for breast cancer screening
decisions, particularly as 20 states now require mammography facilities to
notify women about breast density and encourage discussion of supplemental
screening options," says Dr. Rhodes. "These findings suggest that MBI
has a more favorable balance of additional invasive cancers detected versus
additional biopsies incurred relative to other supplemental screening
options."

"Recent studies have reported supplemental cancer detection rates of
1.9 per 1,000 women screened with automated whole breast ultrasound and 1.2 to
2.8 per 1,000 women screened with digital breast tomosynthesis, so our finding
of an additional 8.8 cancers per 1,000 women makes MBI a very compelling option
for women who elect supplemental screening," says Dr. Rhodes.

Michael O'Connor, Ph.D., a Mayo Clinic scientist and inventor of the MBI
technology, calls this latest study a major milestone for both safety and
efficacy of the imaging device, largely because of the high detection rates
achieved through low radiation exposure.

"This new study is important because it incorporates many of the
advances in MBI pioneered here at Mayo Clinic and shows that studies can be
performed safely, with low radiation exposure to the patient," says Dr.
O'Connor. "This means MBI is safe and effective as a supplemental
screening tool."

"We are very excited about what MBI can offer women with dense
breasts," says Amy Conners, M.D., chair of Mayo Clinic's Breast Imaging
Division and a co-author of this study. "While we endorse annual
mammography for all women age 40 and over, and the addition of annual MRI for
women at high risk, MBI fills an important gap for supplemental screening in
women with dense breasts who are not otherwise at high risk."







Story Source:

The above story is based on materials provided by Mayo Clinic. The original article was written by
Sam Smith. Note: Materials may be edited for content and length.







Journal Reference:

1.    Deborah J. Rhodes, Carrie B. Hruska, Amy
Lynn Conners, Cindy L. Tortorelli, Robert W. Maxwell, Katie N. Jones, Alicia Y.
Toledano, Michael K. O'Connor.JOURNAL CLUB: Molecular Breast Imaging at
Reduced Radiation Dose for Supplemental Screening in Mammographically Dense
Breasts. American Journal of Roentgenology, 2015; 204 (2): 241
DOI: 10.2214/AJR.14.13357

http://www.sciencedaily.com/releases/2015/01/150123101604.htm

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