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Gen bayi , bukan ibu , dapat memicu beberapa kelahiran prematur

Perubahan daerah genetik pada bayi terkait dengan peningkatan risiko kelahiran prematur - dan data mengubah paradigma prematur ....read more

Baby's genes,
not mom's, may trigger some preterm births



Date:



February 2, 2015



Source:



University of Alabama
at Birmingham



Summary:



Changes in genetic
regions in infants linked with an increased risk of premature birth -- and the
data change the preterm paradigm.



....................



some babies may be
genetically predisposed to being born too soon, and variants in the DNA of the
fetus -- not the mother -- may be the trigger for some early births.



That is the finding of research conducted by Joseph Biggio, M.D., professor
and director of the University of Alabama at Birmingham Division of
Maternal-Fetal Medicine in the Department of Obstetrics and Gynecology, and his
colleagues from the Eunice Kennedy Shriver National Institute of Child Health
and Human Development Genomics and Proteomics Network for Preterm Birth
Research. 



Biggio's research analyzed the number of copies of certain segments of DNA
in the blood or saliva from hundreds of babies and their mothers.



"These findings really open a whole different arena for us to look
into as we think about preterm birth," said Biggio, who was assisted by
William Andrews, Ph.D., M.D., professor and chair of UAB's Department of
Obstetrics and Gynecology, and others. "It causes us to think more critically
about the role of the fetus in causing preterm birth. We've always thought
about preterm birth as a maternal issue, but these data change the paradigm. It
may be the fetus who has the underlying predisposition, not the mother. This
still is very preliminary, and more investigation is needed; but the research
clearly identified genetic regions associated with an increased risk of preterm
birth."



No link was established between the number of copies of the mother's genes
and the risk of preterm birth; however, there was a two- to 11-fold increase in
preterm births before 34 weeks of gestation among infants in whom any of four
genes was duplicated or any of seven genes was deleted.



"These findings may help explain what triggers early labor in some
women even when they've done everything right during pregnancy and there's no
obvious cause for an early birth," explained March of Dimes Chief Medical
Officer Edward R.B. McCabe, M.D. "The hope is that this finding may one
day lead to a screening test to help identify which babies are at a higher risk
of an early birth."



The preterm birth rate in the United States dropped more than 10 percent
between 2006 and 2013, with most of the improvement focused in late preterm
births (those between 34 and 37 weeks of pregnancy). Today's research findings
focused on early preterm births -- births before 34 weeks of pregnancy -- in
which there has been little improvement in recent years.



More than 450,000 babies are born too soon each year in the United States,
and Alabama has one of the highest rates of preterm birth in the nation, at
15.1 percent. Preterm birth is the leading cause of newborn death, and babies
who survive an early birth often face an increased risk of a lifetime of health
challenges, such as breathing problems, cerebral palsy, intellectual
disabilities and more. Even babies born just a few weeks early have higher
rates of hospitalization and illness than full-term infants. It is a serious
health problem that costs the United States more than $26 billion annually,
according to the March of Dimes.



While the differences in the number of copies of the genes or gene regions
may not directly cause a preterm birth, they may make a baby more susceptible
to infection or reacting to other harmful environmental factors that trigger
early labor and delivery, Biggio says.



"We don't know exactly that it's the genes in these areas,"
Biggio said. "It may be something else; but these changes are in the areas
of these genes, and that's certainly the first place to start looking."



It may also help explain why treatment with progesterone, a naturally
occurring hormone in pregnancy shown to prevent some preterm births, works for
only about one-third of women.



"We think we are treating the mother with progesterone, but perhaps we
are actually treating the baby or changing the fetal-immune response,"
Biggio said.



The March of Dimes will present its award for Best Research in Prematurity
to Biggio for this work during the annual Society for Maternal-Fetal Medicine
meeting, which begins today in San Diego, California.



"Genetics and informatics are going to be a key to our understanding
of complex disease, and preterm birth is a prime example," Biggio said.
"If we can begin to understand the complexity of preterm birth and can
work to prevent it, we will be able to avert significant health care
expenditures and morbidity."












Story Source:



The above story is based on materials provided by University
of Alabama at Birmingham. Note: Materials may be edited for content and length.



http://www.sciencedaily.com/releases/2015/02/150202080442.htm

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