Protein yang terkait dengan perkembangan asma--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

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Protein  yang terkait dengan perkembangan asma

Para peneliti telah menghubungkan protein tertentu , CCL28 , untuk pengembangan asma pasca infeksi virus , yang merupakan langkah pertama dalam menghasilkan jenis novel terapi asma yang dirancang untuk mencegah perkembangan asma pasca - virus pada anak-anak .....read more

Protein linked
to development of asthma

Date:

February 20, 2015

Source:

Medical College of
Wisconsin

Summary:

Researchers have
linked a specific protein, CCL28, to the development of post-viral infection
asthma, which is the first step in generating a novel type of asthma therapy
designed to prevent development of post-viral asthma in young children.

....................

researchers at the
Medical College of Wisconsin (MCW) have linked a specific protein to the
development of post-viral infection asthma, which is the first step in
generating a novel type of asthma therapy designed to prevent development of
post-viral asthma in young children.

The findings are published in the Journal of Biological Chemistry.

Brian F. Volkman, PhD, professor of biochemistry; and Mitchell H. Grayson,
MD, associate professor of allergy and immunology; are the lead researchers on
the study.

Asthma is a chronic disease of the airways that affects more than 300
million people worldwide. It is the number one illness leading to school
absences in children, and accounts for more than 1.8 million emergency room
visits annually. There is no cure; all current therapies focus on providing
symptomatic relief and reducing the number and severity of attacks.

"Understanding the molecular mechanisms by which asthma develops and
establishes itself as a chronic disease is key to elucidating alternative and
potentially curative therapies," said Dr. Grayson.

The researchers previously found evidence linking a human chemokine
(protein) called CCL28 to the development of chronic asthma. This study is the
first, however, that examines structural analysis and its impact on disease
development.

"We found that even in the absence of a viral infection, CCL28 can
play a role in the induction of asthma pathology--when the protein is natively
folded. If unfolded, it does not," explained Dr. Volkman. "We propose
that by exploiting the unique structural features of CCL28, potent and specific
CCL28 inhibitors may be developed. This work is the first step in generating a
novel type of asthma therapy that may have the power to prevent development of
post-viral asthma in young children."







Story Source:

The above story is based on materials provided by Medical
College of Wisconsin.Note: Materials may be edited for content and length.







Journal Reference:

1.    Monica A. Thomas, Becky J. Buelow,
Amanda M. Nevins, Stephanie E. Jones, Francis C. Peterson, Rebekah L. Gundry,
Mitchell H. Grayson, Brian F. Volkman.Structure-Function Analysis of CCL28
in the Development of Post-viral Asthma. Journal of Biological
Chemistry, 2015; 290 (7): 4528 DOI:10.1074/jbc.M114.627786

http://www.sciencedaily.com/releases/2015/02/150220133344.htm

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