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Diagnosis Ponsel pintar ? Biosensing platform yang cepat dan akurat untuk diagnosa penyakit dan monitor pengobatan jarak jauh
Dalam banyak cara yang sama bahwa glucometers dan tes kehamilan telah merevolusi di tes diagnostik rumah....., peneliti telah mengidentifikasi platform biosensing baru yang dapat digunakan untuk jarak jauh mendeteksi dan menentukan pilihan pengobatan untuk HIV , E - coli , Staphylococcus aureas dan bakteri lainnya . Dengan menggunakan teknologi ini , mereka juga telah mengembangkan aplikasi ponsel yang bisa mendeteksi bakteri dan penyakit dalam darah menggunakan gambar dari ponsel yang dapat dengan mudah dianalisa dari mana saja di dunia ....read more
Smart phone
diagnosis? Biosensing platform quickly and accurately diagnoses disease and
monitors treatment remotely
Date:
April 2, 2015
Source:
Florida Atlantic
University
Summary:
In much the same way
that glucometers and pregnancy tests have revolutionized in-home diagnostic
testing, researchers have identified a new biosensing platform that could be
used to remotely detect and determine treatment options for HIV, E-coli,
Staphylococcus aureas and other bacteria. Using this technology, they also have
developed a phone app that could detect bacteria and disease in the blood using
images from a cellphone that could easily be analyzed from anywhere in the
world.
........................
In much the same way that glucometers and
pregnancy tests have revolutionized in-home diagnostic testing, researchers
from Florida Atlantic University and collaborators have identified a new
biosensing platform that could be used to remotely detect and determine
treatment options for HIV, E-coli, Staphylococcus
aureas and other
bacteria. Using a drop of blood from a fingerprick, this novel biosensing
platform provides clinically relevant specificity, sensitivity and detection of
pathogens from whole blood and plasma.
The thin, lightweight and flexible materials developed by these researchers
can be fabricated and operated without the need for expensive infrastructure
and skilled personnel, potentially solving real-world healthcare problems for
both developed and developing countries. Using this technology, they also have
developed a phone app that could detect bacteria and disease in the blood using
images from a cellphone that could easily be analyzed from anywhere in the
world.
Waseem Asghar, Ph.D., assistant professor of electrical engineering in the
College of Engineering and Computer Science at FAU, co-first author on the
study, along with Hadi Shafiee, Ph.D., instructor in medicine at the Division
of Biomedical Engineering at Brigham and Women's Hospital, Harvard Medical
School; Fatih Inci, Ph.D.; and Utkan Demirci, Ph.D., Stanford School of
Medicine, senior authors on the study, have published their findings in Nature
Scientific Reports in an article titled "Paper and Flexible
Substrates as Materials for Biosensing Platforms to Detect Multiple
Biotargets." Other team members on the study include Mehmet Yuksekkaya,
Ph.D.; Muntasir Jahangir; Michael H. Zhang; Naside Gozde Durmus, Ph.D.; Umut
Atakan Gurkan, Ph.D., and Daniel R. Kuritzkes, M.D.
In the article, the researchers address the limitations of current paper
and flexible material-based platforms and explain how they have integrated
cellulose paper and flexible polyester films as new diagnostic tools to detect
bioagents in whole blood, serum and peritoneal fluid. They employed three
different paper and flexible material-based platforms incorporated with
electrical and optical sensing modalities. They were able to demonstrate how
these new materials can be widely applied to a variety of settings including
medical diagnostic and biology laboratories.
Using paper and flexible substrates as materials for biosensors, Asghar and
his colleagues have identified a new rapid and cost-effective way to diagnose
diseases and monitor treatment in point-of-care settings. They have been able
to show how their new platforms are uniquely able to isolate and detect
multiple biotargets selectively, sensitively, and repeatedly from diverse
biological mediums using antibodies.
"There is a dire need for robust, portable, disposable and inexpensive
biosensing platforms for clinical care, especially in developing countries with
limited resources," said Asghar.
Existing paper and flexible material-based platforms use colorimetric,
fluorometric and electrochemical approaches that require complex labeling steps
to amplify their signal, are very costly to fabricate and also require
expensive equipment and infrastructure.
"The future of diagnostics and health monitoring will have potentially
cell-phone based or portable readers sipping saliva or blood and continuously
monitoring human health taking it way beyond where we are with counting steps
today," said Demirci, who is the corresponding author.
Asghar notes that because their materials are easy to make, easy to use,
and can easily and safely be disposed by burning, they provide appealing strategies
for developing affordable tools that have broad applications such as drug
development, food safety, environmental monitoring, veterinary medicine and
diagnosing infectious diseases in developing countries.
"Our paper microchip technologies can potentially have a significant
impact on infectious diseases management in low- and middle-income countries
where there is limited laboratory infrastructure," said Shafiee.
Demirci notes that these platforms could potentially be adapted and
tailored to detect other pathogens and biotargets with well-known biomarkers.
Story Source:
The above story is based on materials provided by Florida
Atlantic University. Note: Materials may be edited for content and length.
Journal Reference:
1. Hadi Shafiee, Waseem Asghar, Fatih Inci,
Mehmet Yuksekkaya, Muntasir Jahangir, Michael H. Zhang, Naside Gozde Durmus,
Umut Atakan Gurkan, Daniel R. Kuritzkes, Utkan Demirci. Paper and
Flexible Substrates as Materials for Biosensing Platforms to Detect Multiple
Biotargets. Scientific Reports, 2015; 5: 8719 DOI: 10.1038/srep08719