Metode Novel mengidentifikasi anak-anak dengan rematik layak untuk life-saving vaccine--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

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Metode Novel mengidentifikasi anak-anak dengan rematik layak untuk life-saving vaccine

Pre - screening berarti tidak ada kebutuhan untuk menghentikan pengobatan yang penting

Date:

June 12, 2015

Source:

European League Against Rheumatism

Summary:

Hasil baru telah menunjukkan bahwa vaksin cacar dapat efektif dan aman bahkan pada anak-anak dengan penyakit rematik anak/pediatric untuk  menerima pengobatan imunosupresi . Dengan menggunakan checklist untuk pre-screen children , para peneliti mampu mengidentifikasi kelompok pasien yang beragam yang cocok untuk vaksinasi , melindungi mereka dari infeksi berpotensi mengancam nyawa .

....... Penyakit rematik adalah penyakit autoimun , yang timbul ketika serangan pada  tubuh dan kerusakan jaringan sendiri . Dengan demikian , mereka biasanya diobati dengan obat imunosupresan untuk meredam respon imun , namun imunosupresi ini juga meninggalkan pasien dengan risiko infeksi ....more

Novel method
identifies children with rheumatic disease eligible for life-saving vaccine

Pre-screening means there is no need to stop essential treatment

Date:

June 12, 2015

Source:

European League Against Rheumatism

Summary:

New results have shown that the chickenpox vaccine can be effective and
safe even in children with pediatric rheumatic disease receiving
immunosuppression treatment. By using a checklist to pre-screen children, the
investigators were able to identify diverse patient groups suitable for
vaccination, protecting them from a potentially life-threatening infection.

..................

The results of a study presented today at the European League Against
Rheumatism Annual Congress (EULAR 2015) Press Conference showed that the
chickenpox (varicella) vaccine can be effective and safe even in children with
paediatric rheumatic disease receiving immunosuppression treatment. By using a
checklist to pre-screen children, the investigators were able to identify
diverse patient groups suitable for vaccination, protecting them from a
potentially life-threatening infection.

Rheumatic diseases are autoimmune diseases, arising when the body attacks
and damages its own tissues. As such, they are typically treated with
immunosuppressant drugs to dampen the immune response, however this
immunosuppression also leaves patients at risk of infection.

"Although chickenpox is a common and often mild childhood illness, it
can be life-threatening in children with a suppressed immune system, such as
those being treated for rheumatic disease. While a vaccine is available, its
safety in children receiving immunosuppression has long been debated,"
said study investigator Dr. Fabian Speth, German Center for Pediatric and
Adolescent Rheumatology, Germany. "By pre-screening children using
easy-to-obtain immunological criteria, we were able to safely and effectively
vaccinate a major group of immunocompromised children, without having to stop
their treatment. This is a significant development in preventing a persisting,
and sometimes fatal, virus."

Primary infection with varicella zoster virus (VZV) causes chickenpox. A
member of the herpesvirus group, VZV can persist in the body and reactivate at
a later date causing shingles. Chickenpox is highly infectious. Spread
throughout households is very common with infection in up to 90% of vulnerable
individuals who come into contact.

21 VZV-susceptible children aged 2-18 years old took part in the study. All
of the children were receiving immunosuppression therapy for clinically inactive
paediatric rheumatic diseases, such as juvenile idiopathic arthritis or
connective tissue diseases. Prior to vaccination, all of the children were
screened according to an immunologic checklist. Patients meeting the safety
criteria received either a first or second dose of the vaccine without
suspension of their immune-suppression therapy.

There was no evidence of vaccination-induced varicella or associated
complications. None of the patients developed a disease flare and no change in
treatment regimen was required in any patient during a minimum follow up of
four weeks.







Story Source:

The above post is reprinted from materials provided byEuropean
League Against Rheumatism. Note: Materials may be edited
for content and length.

http://www.sciencedaily.com/releases/2015/06/150612091826.htm

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