diet tinggi fruktosa selama kehamilan dapat
membahayakan plasenta , membatasi pertumbuhan janin
Obat yang diresepkan untuk mengobati asam urat
, batu ginjal dapat meniadakan efek buruk gula ini
Date:
May 4, 2016
Source:
Washington University
in St. Louis
Summary:
Penelitian pada tikus dan wanita menemukan bahwa mengkonsumsi diet tinggi fruktosa selama kehamilan dapat menyebabkan cacat pada plasenta dan membatasi pertumbuhan janin , berpotensi meningkatkan risiko bayi untuk masalah kesehatan metabolik di kemudian hari . Namun, allopurinol obat generik , sering diresepkan untuk mengobati asam urat dan batu ginjal , muncul untuk mengurangi dampak ibu dan janin negatif .
Penelitian pada tikus dan wanita menemukan bahwa mengkonsumsi diet tinggi fruktosa selama kehamilan dapat menyebabkan cacat pada plasenta dan membatasi pertumbuhan janin , berpotensi meningkatkan risiko bayi untuk masalah kesehatan metabolik di kemudian hari . Namun, allopurinol obat generik , sering diresepkan untuk mengobati asam urat dan batu ginjal , muncul untuk mengurangi dampak ibu dan janin negatif .
................
Mengkonsumsi diet tinggi fruktosa selama
kehamilan dapat menyebabkan cacat pada plasenta dan membatasi pertumbuhan
janin, berpotensi meningkatkan risiko bayi untuk masalah kesehatan metabolik di
kemudian hari, menurut penelitian pada tikus dan orang-orang oleh tim di Washington
University School of Medicine di St . Louis.Namun, memberikan tikus
allopurinol, obat generik yang sering diresepkan untuk mengobati asam urat dan
batu ginjal, muncul untuk mengurangi dampak ibu dan janin negatif. Temuan
menunjukkan dimungkinkan untuk merancang tes skrining dan rencana perawatan
prenatal untuk wanita hamil dengan kadar fruktosa tinggi.
Penelitian ini tersedia secara online dalam Laporan Ilmiah, jurnal berafiliasi dengan Nature Publishing Group.
Fruktosa, gula alami dalam buah-buahan dan
madu, telah populer selama beberapa dekade antara produsen makanan yang
mengolahnya menjadi sirup jagung tinggi fruktosa yang digunakan
untuk mempermanis makanan dan minuman. Bahkan, para peneliti telah melaporkan
bahwa gula rafinasi selama lebih dari
setengah dari semua pemanis yang digunakan dalam rantai makanan-pasokan AS. Dan
dalam beberapa tahun terakhir, ada kekhawatiran bahwa fruktosa dalam makanan
olahan dan minuman manis mungkin berhubungan dengan diabetes dan obesitas.
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High-fructose
diet during pregnancy may harm placenta, restrict fetal growth
Drug prescribed to treat gout, kidney stones may negate the sugar's ill effects
Date:
May 4, 2016
Source:
Washington University
in St. Louis
Summary:
Research in mice and women found that consuming a high-fructose diet during
pregnancy may cause defects in the placenta and restrict fetal growth,
potentially increasing a baby's risk for metabolic health problems later in
life. However, the generic drug allopurinol, frequently prescribed to treat
gout and kidney stones, appears to mitigate the negative maternal and fetal
effects.
................
Consuming a high-fructose diet during pregnancy may cause defects in the
placenta and restrict fetal growth, potentially increasing a baby's risk for
metabolic health problems later in life, according to research in mice and
people by a team at Washington University School of Medicine in St. Louis.
However, giving the mice allopurinol, a generic drug frequently prescribed
to treat gout and kidney stones, appears to mitigate the negative maternal and
fetal effects. The findings suggest it may be possible to devise a prenatal
screening test and treatment plan for pregnant women with high fructose levels.
The study is available online in Scientific Reports, a journal
affiliated with Nature Publishing Group.
Fructose, a sugar occurring naturally in fruits and honey, has been popular
for decades among food manufacturers who process it into high-fructose corn
syrup used to sweeten food and beverages. In fact, researchers have reported
that the refined sugar accounts for more than half of all sweeteners used in
the U.S. food-supply chain. And in recent years, there's growing concern that
fructose in processed foods and sugary drinks may be linked to diabetes and
obesity.
"Since the early 1970s, we've been eating more fructose than we
should," said Kelle H. Moley, MD, the School of Medicine's James P. Crane
Professor of Obstetrics and Gynecology and the study's senior author. "It
is becoming increasingly critical to understand how fructose consumption is
impacting human health. This study shows potentially negative effects of a
high-fructose diet during pregnancy."
Fructose is processed differently than other sugars such as glucose, which
the body converts into energy. Instead, fructose is broken down by liver cells
that turn the sugar into a form of fat known as triglycerides while also
driving high levels of uric acid, a normal waste product found in urine and
stool. Too much uric acid can create metabolic mayhem resulting in obesity,
type 2 diabetes and other health conditions.
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Fruktosa diproses secara berbeda dari gula lain seperti glukosa , yang mengubah tubuh menjadi energi . Sebaliknya , fruktosa dipecah oleh sel-sel hati yang mengubah gula menjadi bentuk lemak yang dikenal sebagai trigliserida sementara juga pembawa tingkat tinggi asam urat , produk limbah yang normal ditemukan dalam air seni dan tinja . Terlalu banyak asam urat dapat membuat kekacauan metabolisme yang mengakibatkan obesitas , diabetes tipe 2 dan kondisi kesehatan lainnya .
Studying mice, the researchers found elevated uric acid and triglycerides
in otherwise healthy mice who were fed a high-fructose diet during pregnancy.
Additionally, the mice developed smaller fetuses and larger placentas than
those fed standard rodent chow.
Genetically, Moley said, a small fetus may become wired to grow more after
birth than a normal-sized fetus. "The body tries to compensate for the
small growth in utero," Moley said. "These babies can become kids and
then adults struggling with obesity and other health problems."
Maternal health also may suffer. Metabolic problems caused by high levels
of uric acid and fat increase a woman's risk of developing pregnancy
complications such as preeclampsia -- a potentially serious condition in
pregnancy often marked by high blood pressure, swelling and high protein levels
in the urine -- and gestational diabetes, Moley said.
To assess the relevance of the mouse data in pregnant women, the
researchers examined the association between fructose and placental uric acid
levels in a small controlled group of 18 women who underwent scheduled cesarean
sections. The women had no disorders that would have caused elevated uric acid.
"We found a correlation suggesting similar maternal and fetal effects
occur in humans," Moley said.
In the mouse model, researchers found that giving mice with high-fructose
levels the common drug allopurinol -- a prescription medication that reduces
uric acid -- reversed the refined sugar's negative maternal and fetal effects
by reducing the levels of uric acid in the placenta.
"The negative effect of excess fructose in humans is likely to lead to
an exacerbation of the problems seen in the mice," said Moley, who
believes additional research may lead to a prenatal screening test for
measuring fructose levels. This can be determined by simple blood work.
Besides advising pregnant women to limit fructose in their diets, treatment
for those with high-fructose levels may include administering allopurinol,
which crosses the placenta and generally is considered safe to take late in the
second trimester or third trimester during pregnancy, Moley said.
"One of the best ways to ensure healthy maternal and fetal outcomes is
by eating natural foods," she said. Future studies will test the
effectiveness of giving allopurinol to pregnant women when there is concern
about fetal growth, Moley added.
The study's lead author was Zeenat Asghar, a graduate student in molecular
cell biology in the university's Division of Biology and Biomedical Sciences.
Story Source:
The above post is reprinted from materials provided byWashington
University in St. Louis. Note: Materials may be edited for content
and length.
Journal Reference:
1.
Zeenat A. Asghar, Alysha Thompson, Maggie Chi, Andrew Cusumano, Suzanne
Scheaffer, Noor Al-Hammadi, Jessica L. Saben, Kelle H. Moley. Maternal
fructose drives placental uric acid production leading to adverse fetal
outcomes. Scientific Reports, 2016; 6: 25091 DOI:10.1038/srep25091
Sumber :