obat kanker bisa promosikan meregenerasi jaringan jantung-T-REC semarang
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KSE-komunitas satwa eksotik—komunitas semarang
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berita artikel terkait tentang kanker,obat kanker,jantung
obat kanker bisa promosikan meregenerasi jaringan jantung
Tanggal:
3 Februari 2017
Sumber:
UT Southwestern Medical Center
Ringkasan:
Agen antikanker dalam pengembangan mempromosikan regenerasi otot jantung
yang rusak - temuan penelitian yang tak terduga yang dapat membantu mencegah
gagal jantung kongestif di masa depan.
................................
Agen antikanker dalam pengembangan mempromosikan regenerasi
otot jantung yang rusak 0- penelitian temuan tak terduga yang dapat membantu
mencegah gagal jantung kongestif di masa depan.
Banyak bagian tubuh, seperti sel-sel darah dan lapisan usus, terus memperbaharui
sepanjang hidup. Lainnya, seperti jantung, yang tidak. Karena ketidakmampuan
jantung untuk memperbaiki dirinya sendiri, kerusakan yang disebabkan oleh
serangan jantung menyebabkan jaringan parut permanen yang sering
mengakibatkan melemahnya jantung secara serius, dikenal sebagai gagal jantung.
Selama bertahun-tahun, Dr. Lawrence Lum,
Associate Professor of Cell Biology at UT Southwestern Medical Center, telah bekerja untuk
mengembangkan obat kanker yang menargetkan Wnt sinyal molekul .
Molekul-molekul ini sangat penting untuk regenerasi jaringan, tetapi juga sering
menyebabkan kanker. Penting untuk produksi protein Wnt pada manusia adalah
porcupine (Porcn) enzim, dinamakan demikian karena embrio lalat buah
yang kekurangan gen ini menyerupai landak/porcupine.
Dalam pengujian porcupine inhibitor peneliti mengembangkan,
mereka mencatat rasa ingin tahu.
................................
label
Cancer drug could promote regeneration of heart tissue,obat kanker bisa mempromosikan
regenerasi pada jaringan jantung,anticancer
agent,kanker,porcupine,Porcn,cardiomyocytes,Collagen,fibrotic
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Cancer drug could promote regeneration of heart tissue
Date:
February
3, 2017
Source:
UT
Southwestern Medical Center
Summary:
An anticancer agent in development promotes regeneration of
damaged heart muscle -- an unexpected research finding that may help prevent
congestive heart failure in the future.
................................
An anticancer agent in development promotes regeneration of damaged heart
muscle 0- an unexpected research finding that may help prevent congestive heart
failure in the future.
Many parts of the body, such as blood cells and the lining of the gut,
continuously renew throughout life. Others, such as the heart, do not. Because
of the heart's inability to repair itself, damage caused by a heart attack
causes permanent scarring that frequently results in serious weakening of the
heart, known as heart failure.
For years, Dr. Lawrence Lum, Associate Professor of Cell Biology at UT
Southwestern Medical Center, has worked to develop a cancer drug targeting Wnt
signaling molecules. These molecules are crucial for tissue regeneration, but
also frequently contribute to cancer. Essential to the production of Wnt
proteins in humans is the porcupine (Porcn) enzyme, so-named because fruit fly
embryos lacking this gene resemble a porcupine. In testing the porcupine
inhibitor researchers developed, they noted a curiosity.
"We saw many predictable adverse effects -0 in bone and hair, for
example 0- but one surprise was that the number of dividing cardiomyocytes
(heart muscle cells) was slightly increased," said Dr. Lum, senior author
of the paper, and a member of UTSW's Hamon Center for Regenerative Science and
Medicine. "In addition to the intense interest in porcupine inhibitors as
anticancer agents, this research shows that such agents could be useful in
regenerative medicine."
Based on their initial results, the researchers induced heart attacks in
mice and then treated them with a porcupine inhibitor. Their hearts' ability to
pump blood improved by nearly twofold compared to untreated animals.
The study findings were published online this week inProceedings of the
National Academy of Sciences.
"Our lab has been studying heart repair for several years, and it was
striking to see that administration of a Wnt inhibitor significantly improved
heart function following a heart attack in mice," said Dr. Rhonda
Bassel-Duby, Professor of Molecular Biology and Associate Director of the Hamon
Center for Regenerative Science and Medicine.
Importantly, in addition to the improved pumping ability of hearts in the
mice, the researchers noticed a reduction in fibrosis, or scarring in the
hearts. Collagen-laden scarring that occurs following a heart attack can cause
the heart to inappropriately increase in size, and lead to heart failure.
"While fibrotic responses may be immediately beneficial, they can overwhelm
the ability of the heart to regenerate in the long run. We think we have an
agent that can temper this fibrotic response, thus improving wound healing of
the heart," said Dr. Lum, a Virginia Murchison Linthicum Scholar in
Medical Research and Associate Director of Basic Research at the Harold C.
Simmons Comprehensive Cancer Center.
Additionally, Dr. Lum said, preliminary experiments indicate that the
porcupine inhibitor would only need to be used for a short time following a
heart attack, suggesting that the unpleasant side effects typically caused by
cancer drugs might be avoided.
"We hope to advance a Porcn inhibitor into clinical testing as a
regenerative agent for heart disease within the next year," Dr. Lum said.
Story Source:
Journal Reference:
1.
Jesung Moon, Huanyu Zhou, Li-shu Zhang, Wei Tan, Ying Liu, Shanrong Zhang,
Lorraine K. Morlock, Xiaoping Bao, Sean P. Palecek, Jian Q. Feng, Noelle S.
Williams, James F. Amatruda, Eric N. Olson, Rhonda Bassel-Duby, Lawrence
Lum. Blockade to pathological remodeling of infarcted heart tissue
using a porcupine antagonist. Proceedings of the National Academy
of Sciences, 2017; 201621346 DOI:10.1073/pnas.1621346114
