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Ini dia Endoscope zaps Tumor
Untuk
menguji organ, dokter sering menggunakan tabung dengan cahaya dan kamera kecil
yang melekat padanya. Perangkat, yang disebut endoskopi, membantu mendeteksi
kanker dan penyakit lainnya. Perangkat ini akan segera melayani tujuan lain: kejutan
listrik /zapping tumor. Kemajuan biomedis, yang sedang dalam tahap
pengembangan, bisa membuat kemoterapi lebih efisien, mengurangi efek samping
dan meningkatkan bagaimana untuk mengobati beberapa bentuk yang paling mematikan
dari kanker......read more
.........................
This Endoscope
Zaps Tumors
Date:
December 22, 2014
Source:
University at Buffalo
Summary:
To examine internal
organs, doctors often use a tube with light and a tiny camera attached to it.
The device, called an endoscope, helps detect cancer and other illnesses. It
may soon serve another purpose: zapping tumors. The biomedical advancement,
which is under development, could make chemotherapy more efficient, reduce its
side effects and improve how doctors treat some of the most deadly forms of
cancer.
......................
To examine internal
organs, doctors often use a tube with light and a tiny camera attached to it.
The device, called an endoscope, helps detect cancer and other illnesses.
It may soon serve another purpose: zapping tumors.
The biomedical advancement, which is under development at the University at
Buffalo, could make chemotherapy more efficient, reduce its side effects and
improve how doctors treat some of the most deadly forms of cancer.
"We are developing a novel endoscopic device that will improve our
ability to detect and destroy cancer cells," says Ulas Sunar, PhD, a
research assistant professor in UB's Department of Biomedical Engineering and
the principal investigator of a National Institutes of Health grant that supports
the research.
Conventional endoscopic imaging has limitations. Its image contrast is
distorted because light scatters and is absorbed by the body. This leads to
blurred or low-contrast images of the tumor environment that limit doctors'
ability to visualize tumors.
To overcome these deficiencies, the new endoscope utilizes spatial
frequency domain imaging. This new technique corrects the image contrast
problem by projecting patterns of light at different frequencies on the cancer
cells. This results in a high-contrast map of the tumor environment.
"We expect doctors in the operating room will greatly benefit from
this device," Sunar says.
The next step is to zap the tumors.
Chemotherapy drugs will be delivered intravenously. But unlike conventional
treatment, the drugs will be encapsulated in tiny liposomes called
nanoballoons. This technology -- under development by Jonathan Lovell, PhD, UB
assistant professor of biomedical engineering -- carries the drugs to the tumor
while shielding them from healthy cells, thus reducing side effects. Upon
reaching the cancer cells, doctors strike the nanoballons with the endoscopic
light beam, causing them to pop open and release the drug directly at the
tumor.
To effectively target the nanoballoons, doctors need to control the light
beam. Sunar is developing a "digital mask" that adjusts the beam's
intensity as well as manipulates its shape down to micron (one millionth of a
meter) precision using a computer.
"The mask is sort of like the Bat signal from Batman movies. It alters
the shape of the light," he says. "At the same time, we'll be able to
control the strength of the light. The combination will allow us to manipulate
the beam to target cancer cells with unprecedented accuracy."
The system could be especially useful for treating ovarian cancer that has
spread to the abdomen, as well as cancer in the lungs, gastrointestinal tract,
mouth and other internal organs, he said.
Sunar will spend much of 2015 developing the system. He will then test it
on animal models. Upon completion of the grant in 2016, he expects to begin a
pilot study with Shashikant Lele, MD, clinical chief of gynecologic oncology at
Roswell Park Cancer Institute, and professor of gynecology and obstetrics at
the UB School of Medicine and Biomedical Sciences.
Story Source:
The above story is based on materials provided by University at
Buffalo. The original article was written by Cory Nealon. Note: Materials
may be edited for content and length.
