T-REC NEWS 4 U: glioblastoma

Luasnya reseksi terkait dengan kemungkinan bertahan hidup dengan glioblastoma---T-REC semarang--komunitas reptil-semarang--KSE-komunitas satwa eksotik—komunitas semarang—komunitas reptil—komunitas reptil semarang—komunitas satwa—komunitas satwa semarang--berita artikel terkait tentang reseksi dan glioblastoma

05.46

reseksi

Luasnya reseksi terkait dengan kemungkinan bertahan hidup dengan  glioblastoma

Date:

June 16, 2016

Source:

The JAMA Network Journals

Summary:

Luasnya reseksi pada pasien dengan glioblastoma , tumor otak yang agresif dan sering fatal , dikaitkan dengan kemungkinan kelangsungan hidup dan perkembangan penyakit , menurut sebuah studi baru .

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Luasnya reseksi pada pasien dengan glioblastoma , tumor otak yang agresif dan sering fatal , dikaitkan dengan kemungkinan kelangsungan hidup dan perkembangan penyakit , menurut sebuah studi baru yang diterbitkan secara online oleh JAMA Oncology .

Glioblastoma multiforme ( GBM ) adalah tumor otak ganas yang paling umum pada orang dewasa . Kombinasi yang optimal dari medis terapi , bedah dan radiasi belum ditetapkan . Komponen bedah dapat berkisar dari biopsi invasif minimal untuk kraniotomi ( pembukaan tengkorak ) dengan tujuan reseksi total bruto ( GTR ) . Tapi tidak setiap pasien menerima reseksi agresif . Anatomi otak dan kekhawatiran tentang cedera struktur di sekitarnya penting dengan penurunan nilai dan menyebabkan berarti tujuan GTR bisa sulit untuk dicapai.

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Extent of resection associated with likelihood of survival in glioblastoma

Date:

June 16, 2016

Source:

The JAMA Network Journals

Summary:

The extent of resection in patients with glioblastoma, an aggressive and often fatal brain tumor, was associated with the likelihood of survival and disease progression, according to a new study.

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The extent of resection in patients with glioblastoma, an aggressive and often fatal brain tumor, was associated with the likelihood of survival and disease progression, according to a new study published online by JAMA Oncology.

Glioblastoma multiforme (GBM) is the most common malignant brain tumor in adults. The optimal combination of medical, surgical and radiation therapy has not been defined. The surgical component can range from minimally invasive biopsy to a craniotomy (opening of the skull) with the goal of gross total resection (GTR). But not every patient receives an aggressive resection. The anatomy of the brain and concern about injury to important surrounding structures with resulting impairment mean the goal of GTR can be difficult to attain.

Michael Glantz, M.D., of the Penn State Milton S. Hershey Medical Center, Hershey, Penn., and coauthors compared GTR with subtotal resection (STR) or biopsy with overall and progression-free survival in a meta-analysis of 37 studies (41,117 patients).

The study reports a lower relative risk of death at one and two years. The authors suggest GTR may increase the likelihood of 1-year survival compared with STR by about 61 percent and may increase the likelihood of two-year survival by about 19 percent. The one-year risk for mortality for STR compared with biopsy was reduced and the risk for mortality was less for any resection compared with biopsy at years one and two, according to the results.

Overall, a reduction in mortality was associated with an increasing extent of resection. GTR also was associated with decreased disease progression over one year, according to the results.

The authors note the results should be interpreted in the context of important caveats, including that GTR and STR groups differed on a number of factors and that the extent of tumor resection was defined by authors in studies, often imprecisely.

"Although the available studies are retrospective and mostly carry a high risk for bias and confounding, an overwhelming consistency of the evidence (including three class 2 studies) supports the superiority of GTR over STR and biopsy. ... Therefore, when clinically feasible, the body of literature favors GTR in all patients with newly diagnosed GBM," the authors conclude.

Story Source:

The above post is reprinted from materials provided by The JAMA Network Journals. Note: Materials may be edited for content and length.

Journal Reference:

1. Timothy J. Brown, Matthew C. Brennan, Michael Li, Ephraim W. Church, Nicholas J. Brandmeir, Kevin L. Rakszawski, Akshal S. Patel, Elias B. Rizk, Dima Suki, Raymond Sawaya, Michael Glantz. Association of the Extent of Resection With Survival in Glioblastoma. JAMA Oncology, 2016; DOI: 10.1001/jamaoncol.2016.1373

https://www.sciencedaily.com/releases/2016/06/160616120504.htm

Dalam tes laboratorium , terapi baru memperlambat penyebaran sel tumor otak yang mematikan--TREC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

08.43

tumor otak

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Dalam tes laboratorium , terapi baru memperlambat penyebaran sel tumor otak yang mematikan

Date:

July 27, 2015

Source:

University of Florida

Summary:

Penyebaran cepat dari tumor otak umum dan mematikan telah melambat secara signifikan pada model tikus dengan memotong jalan beberapa sel kanker berkomunikasi , menurut tim peneliti .

........... Teknik meningkatkan waktu bertahan untuk pasien dengan glioblastoma dengan  50 persen saat diuji pada model tikus , kata Loic P. Deleyrolle , Ph.D. , seorang asisten peneliti profesor bedah saraf di UF College of Medicine .

Para peneliti berfokus pada mengganggu komunikasi sel ke sel yang memungkinkan sel-sel induk kanker menyebar . Untuk melakukan itu , mereka mentargetkan saluran yang sel-sel kanker gunakan untuk mentransfer molekul . Dengan memotong jalur komunikasi mereka , sel-sel mematikan tinggal di cek , kata Deleyrolle ....more

In lab tests, new therapy slows spread of deadly brain tumor cells

Date:

July 27, 2015

Source:

University of Florida

Summary:

The rapid spread of a common and deadly brain tumor has been slowed down significantly in a mouse model by cutting off the way some cancer cells communicate, according to a team of researchers.

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The rapid spread of a common and deadly brain tumor has been slowed down significantly in a mouse model by cutting off the way some cancer cells communicate, according to a team of researchers that includes UF Health faculty.

The technique improved the survival time for patients with glioblastoma by 50 percent when tested in a mouse model, said Loic P. Deleyrolle, Ph.D., a research assistant professor of neurosurgery in the UF College of Medicine.

Researchers focused on disrupting the cell-to-cell communication that allows cancer stem cells to spread. To do that, they targeted a channel that cancer cells use to transfer molecules. By cutting off their communications pathway, the deadly cells stay in check, Deleyrolle said.

Eight UF Health researchers took part in the study, which was co-authored by Deleyrolle and published recently in the journalCell Reports. They collaborated with researchers at the Cleveland Clinic and the University of California, Berkeley.

Glioblastoma is the most common brain tumor in adults and there is no effective long-term treatment and patients usually live for 12 to 15 months after diagnosis, according to the National Cancer Institute. Glioblastoma tumors, which are highly malignant, typically start in the largest part of the brain and can spread rapidly.

The research focused on connexin 46, a protein that is an essential component of cancer stem cells. Connexin 46 is part of intercellular channels known as a gap junction. That intercellular channel, which allows cells to exchange molecules and ions, is crucial to the growth of a glioblastoma tumor, researchers found.

"When we shut down those channels in the cancer stem cells, we can significantly reduce the tumor-forming abilities of the cells," Deleyrolle said.

Tumor growth was significantly delayed in mouse models that were treated with a combination of the gap junction inhibitor 1-octanol and a chemotherapy drug, temozolomide. After 100 days, all of the mouse models that had the connexin 46 protein suppressed genetically were still alive. By comparison, all of the mouse models that didn't have the protein suppressed died within two months.

While the technique has yet to be tested in humans, Deleyrolle said the implications are clear and relevant. For now, a glioblastoma patient can expect to survive about 12 to 15 months. Patients can also develop a resistance to temozolomide when it is used for chemotherapy, further shortening their life expectancy.

"Any significant increase in survival time will be a meaningful improvement because the current treatments provide only weeks of efficacy" Deleyrolle said.

Another reason for optimism: All of the compounds that were tested as inhibitors are being used in humans or are in the clinical trial pipeline. Carbenoxolone is used in some European countries to treat ulcers, and 1-octanol is used as experimental treatment for tremor in the United States. That means that the amount of time needed to get the drugs into a clinical trial as a therapy for glioblastoma could be significantly shortened, Deleyrolle said.

Because gap junction inhibitors have ubiquitous functions in many organs and tissues, one of the next research steps is to determine the inhibitors' most effective and tolerable concentrations. It is also necessary to understand more about the mechanisms that make the inhibitors work, Deleyrolle said. Still, clinical trials could begin within a few years, he said.

Treating glioblastoma is especially difficult because its cells can vary drastically, even within a single tumor -- so breaking the chain of cell-to-cell communication is yet another potential weapon to fight the disease. If the new therapy is approved following a clinical trial, Deleyrolle said it would likely be put to use alongside traditional chemotherapy and radiation treatments.

Deleyrolle said he is seeking a new federal grant to continue translational research.

"When it comes down to treating such a complex disease, there isn't one magic bullet. You have to come up with complex, multiple approaches, he said.

Story Source:

The above post is reprinted from materials provided byUniversity of Florida. The original item was written by Doug Bennett. Note: Materials may be edited for content and length.

Journal Reference:

1. Masahiro Hitomi, Loic P. Deleyrolle, Erin E. Mulkearns-Hubert, Awad Jarrar, Meizhang Li, Maksim Sinyuk, Balint Otvos, Sylvain Brunet, William A. Flavahan, Christopher G. Hubert, Winston Goan, James S. Hale, Alvaro G. Alvarado, Ao Zhang, Mark Rohaus, Muna Oli, Vinata Vedam-Mai, Jeff M. Fortin, Hunter S. Futch, Benjamin Griffith, Qiulian Wu, Chun-hong Xia, Xiaohua Gong, Manmeet S. Ahluwalia, Jeremy N. Rich, Brent A. Reynolds, Justin D. Lathia.Differential Connexin Function Enhances Self-Renewal in Glioblastoma. Cell Reports, 2015; 11 (7): 1031 DOI: 10.1016/j.celrep.2015.04.021

http://www.sciencedaily.com/releases/2015/07/150727130818.htm

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Dalam tes laboratorium , terapi baru memperlambat penyebaran sel tumor otak yang mematikan--TREC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

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