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Pembuluh darah buatan memungkinkan peneliti lebih baik menilai perangkat penghapusan bekuan

In vitro ,  vessel sel hidup-buatan  telah diciptakan yang dapat digunakan untuk mempelajari kedua aplikasi dan efek dari perangkat yang digunakan untuk mengekstrak pembekuan darah yang mengancam jiwa di otak . vessel  buatan bisa memiliki implikasi signifikan bagi pembangunan masa depan teknologi endovascular , termasuk mengurangi kebutuhan untuk model hewan untuk menguji perangkat baru atau pendekatan ....read more

Artificial blood
vessel lets researchers better assess clot removal devices

Date:

April 17, 2015

Source:

University of
California, San Diego Health Sciences

Summary:

An in vitro, live-cell
artificial vessel has been created that can be used to study both the
application and effects of devices used to extract life-threatening blood clots
in the brain. The artificial vessel could have significant implications for
future development of endovascular technologies, including reducing the need
for animal models to test new devices or approaches.

..........................

researchers at the
University of California, San Diego School of Medicine have created an in
vitro, live-cell artificial vessel that can be used to study both
the application and effects of devices used to extract life-threatening blood
clots in the brain. The artificial vessel could have significant implications
for future development of endovascular technologies, including reducing the
need for animal models to test new devices or approaches.

The findings are published in the current online issue of the journal Stroke.

Cerebrovascular disease covers a group of dysfunctions related to blood
vessels supplying the brain. Risk factors include hypertension, diabetes,
smoking and ischemic heart disease. More than 6 million American adults are
affected, with the number steadily growing.

When blood supply to the brain is significantly diminished or blocked, an
acute stroke may result, requiring quick medical intervention to avoid
permanent brain damage or death. More than 795,000 Americans experience a
stroke each year; 130,000 die.

"Timely restoration of normal blood flow is absolutely critical,"
said Alexander Khalessi, MD, director of endovascular neurosurgery and surgical
director of neurocritical care at UC San Diego Health System.
"Clot-dissolving drugs like tPA (tissue plasminogen activator) help, but
might not work sufficiently fast or fully in some situations. In those cases,
doctors must perform endovascular thrombectomies where they mechanically remove
the emboli or clots."

The rate of endovascular thrombectomies is rising, but the approach, which
typically involves running a catheter to the site of the blockage and using one
of several marketed devices to remove the clot, can be improved, said Khalessi.
For example, some patients experience negative consequences caused by either
the mechanical removal of the emboli or by the restoration of blood flow,
called reperfusion, specifically to the endothelial cells (ECs) that form the
lining of blood vessels.

Current pre-clinical analyses of new therapeutic approaches or devices is
limited to either in vitro glass or plastic tubing testing
intended to mimic biological counterparts or by using animal models, such as
pigs.

"Both of these have significant drawbacks. Although transparent and
thus easier to study, glass and plastic tubing does not recapitulate blood
vessel biology," said Khalessi. "In vivo animal models
are more realistic, but we cannot directly observe the interaction between
devices and ECs. Plus animals are not perfect models of humans and they are
expensive to use."

Khalessi, along with co-author Shu Chien, MD, PhD, director of UC San
Diego's Institute of Engineering in Medicine, and colleagues developed a
novel in vitro live-cell platform that allows direct visual
characterization of effects and injury patterns to ECs. Bovine artery ECs were
perfused into optically clear, biocompatible tubular silicone with a thickness
of 0.25 millimeters and inner diameters of 2.5, 3.5 and 4.5 millimeters.

The researchers then introduced porcine blood clots into the platform,
allowing the clots to integrate, tested various clot-retrieval devices and
examined the post-removal effects.

"We found that the in vitro platform permitted
high-resolution quantification and characterization of the pattern and timing
of EC injury with various thrombectomy devices and vessel diameters. The
devices each displayed different effects."

The researchers subsequently validated their in vitro findings
with in vivo testing.

"This work offers significant promise going forward," said
Khalessi. "The live-cell artificial vessel enabled us to conduct detailed
studies of the endothelium after thrombectomy, which may contribute to future
device design. Animal studies confirmed the relevance of the platform, which
suggests the artificial model could represent a practical, scalable and
physiological alternative to existing technologies."







Story Source:

The above story is based on materials provided by University
of California, San Diego Health Sciences. Note: Materials may be edited for content
and length.







Journal Reference:

1.    D. Teng, J. S. Pannell, R. C. Rennert,
J. Li, Y.-S. Li, V. W. Wong, S. Chien, A. A. Khalessi. Endothelial
Trauma From Mechanical Thrombectomy in Acute Stroke: In Vitro Live-Cell
Platform With Animal Validation. Stroke, 2015; 46 (4): 1099
DOI: 10.1161/STROKEAHA.114.007494

http://www.sciencedaily.com/releases/2015/04/150417145029.htm

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