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Obat
keropos tulang dapat membantu mencegah kanker endometrium
Wanita yang
menggunakan bifosfonat - obat yang biasa digunakan untuk mengobati osteoporosis
dan kondisi tulang lainnya - memiliki hanya sekitar setengah dari risiko terkena
kanker endometrium dengan perempuan yang tidak menggunakan obat-obatan, ini menunjukkan analisis baru.....read more
...........................
Bone loss drugs
may help prevent endometrial cancer
Date:
December 22, 2014
Source:
Wiley
Summary:
Women who use
bisphosphonates -- medications commonly used to treat osteoporosis and other
bone conditions -- have about half the risk of developing endometrial cancer as
women who do not use the drugs, a new analysis shows.
.....................
A new analysis suggests
that women who use bisphosphonates--medications commonly used to treat
osteoporosis and other bone conditions--have about half the risk of developing
endometrial cancer as women who do not use the drugs. Published early online in CANCER, a peer-reviewed journal
of the American Cancer Society, the study supports other research that has
shown an anti-cancer effect of this type of medication.
Endometrial cancer, which arises in the lining of the uterus, accounts for
nearly 50 percent of gynecologic cancers diagnosed in the United States, and it
is the fourth most common malignancy in women and the eighth most common cause
of cancer death. While bisphosphonates are known to prevent bone loss,
preclinical studies have shown that the medications also have antitumor
effects, including the ability to keep tumor cells from multiplying and from
invading normal tissues.
To assess whether bisphosphonates might help prevent endometrial cancer,
Sharon Hensley Alford, PhD, of the Henry Ford Health System in Detroit, led a
team that evaluated information from the National Cancer Institute's PLCO
(Prostate, Lung, Colorectal, and Ovarian) Screening Trial, which included
questionnaires about bone medication use. The researchers analyzed data for
only those bisphosphonates that contain nitrogen as these are known to have
stronger anticancer activity.
A total of 29,254 women were included in the analysis. After accounting for
factors including age, race, history of hormone therapy use, smoking status,
and body mass index, bisphosphonate users were half as likely to develop
endometrial cancer.
"Other studies have shown that bisphosphonates may reduce the risk of
certain cancers, but we are the first to show that the risk for endometrial
cancer may also be reduced," said Dr. Alford. "This study suggests
that women who need bone strengthening medications and who have increased risk
for endometrial cancer may want to choose the nitrogen form of bisphosphonates
because this form may reduce the risk of endometrial cancer."
Story Source:
The above story is based on materials provided by Wiley. Note: Materials may be edited
for content and length.
Journal Reference:
1. Sharon Hensley Alford, Ramandeep Rattan,
Thomas Buekers, and Adnan Munkarah. Protective effect of
bisphosphonates on endometrial cancer incidence in the PLCO data. CANCER,
December 2014 DOI:10.1002/cncr.28952
