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Infeksi tersembunyi memperpendek  kehidupan pada burung

penelitian menunjukkan , Infeksi ringan tanpa gejala penyakit dapat menyebabkan konsekuensi serius dengan mengurangi umur dari  yang terinfeksi ,. Sebuah studi baru telah dilakukan pada burung migran yang terinfeksi malaria . Infeksi ini diduga  mempercepat proses penuaan dengan memperpendek telomere ( yaitu , kromosom berakhir/ i.e., the chromosomes ends  ) pada tingkat yang lebih cepat dan dengan demikian mempercepat penuaan ....read more

Hidden infection
shortens life in birds

Date:

January 23, 2015

Source:

Lund University

Summary:

Mild infections
without symptoms of illness can still lead to serious consequences by reducing
the lifespan of the infected individuals, research shows. A new study has been
carried out on malaria-infected migratory birds. The infection is thought to
speed up the aging process by shortening the telomeres (i.e., the chromosomes
ends) at a faster rate and thereby accelerating senescence. 

..................

recent research shows
that mild infections without symptoms of illness can still lead to serious
consequences by reducing the lifespan of the infected individuals. The study at
Lund University in Sweden has been carried out on malaria-infected migratory
birds. The infection is thought to speed up the aging process by shortening the
telomeres (i.e., the chromosomes ends) at a faster rate and thereby
accelerating senescence.

Until now, the research community had believed that mild infections that do
not produce symptoms of illness have no effect on survival and reproduction.
However, a new study shows that a malaria infection that produces no obvious
direct negative effects still has an impact; in the long run it can have
serious consequences in the form of a shortened lifespan.

"If this is a general mechanism for any type of mild, chronic
infection, which is quite possible, it will mean our study is of major interest
to understand the impact that mild illnesses can have on other organisms,
including humans," says Professor Dennis Hasselquist from the Department
of Biology, Lund University, one of the researchers behind the study.

According to the researchers, the new study contains a number of very
surprising results. Previously, it was thought that a mild infection only
produced small, temporary effects that the body could quickly compensate for.

"However, our results show instead that these types of small effects
that appear harmless effects could accumulate and speed up the body's aging
process, leading to the earlier death of the individual. This is a new,
surprising discovery," says Staffan Bensch, Professor of Biology at Lund
University and another of the authors of the study.

The reason why these small effects shorten life in the long run could be a
mechanism linked to the chromosomes in the cells of the individual affected.
The ends of the chromosomes, known as telomeres, protect the DNA from damage.
The longer these chromosome ends are, the greater the chance of living a longer
life. The present study shows that a mild malaria infection in birds causes the
telomeres to shorten considerably faster in infected individuals as compared
with healthy individuals.

"The small, non-measureable effects of the chronic disease appear to
underlie the accelerated shortening of the telomeres. When the telomeres get
too short, this has a fatal effect and causes premature death," says
Dennis Hasselquist.

The researchers have studied malaria in great reed warblers, a species of
migratory bird that breeds every summer on Lake Kvismaren near Örebro, Sweden,
and spends winters in tropical Africa. Great reed warblers that had chronic
malaria, but with an extremely low number of parasites in the blood and without
any signs of illness, produced half as many young during their lifetime as
birds that were not infected. The size of the broods was the same as for the
healthy birds, but because the infected individuals had a shorter lifespan, the
total number of young was significantly lower. The infected birds appeared to
function just as well in their daily lives as the healthy birds, and could work
as hard in their daily life.

"Infected males sang every bit as much as healthy males, i.e. 21 hours
a day. Infected females fed their young just as intensively as those that were
not infected," says Dennis Hasselquist.







Story Source:

The above story is based on materials provided by Lund University. Note: Materials may be edited
for content and length.







Journal Reference:

1.    M. Asghar, D. Hasselquist, B. Hansson,
P. Zehtindjiev, H. Westerdahl, S. Bensch.Hidden costs of infection: Chronic
malaria accelerates telomere degradation and senescence in wild birds. Science,
2015; 347 (6220): 436 DOI: 10.1126/science.1261121

http://www.sciencedaily.com/releases/2015/01/150123081727.htm

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