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Studi genetik menyoroti bagaimana nyamuk men transmit  malaria 

Urutan genetik dari 16 nyamuk ( Anopheles genus ) - satu-satunya pembawa malaria manusia - telah ditentukan oleh tim peneliti internasional , memberikan wawasan baru bagaimana mereka beradaptasi dengan manusia sebagai tuan rumah utama penyakit .

Genetic study
sheds light on how mosquitoes transmit malaria

Date:

December 23, 2014

Source:

Simon Fraser
University

Summary:

The genetic sequencing
of 16 mosquitoes (Anopheles genus) -- the sole carriers of human malaria -- has
been determined by an international team of researchers, providing new insight
into how they adapt to humans as primary hosts of the disease.

.................

An international research
team, including researchers from Simon Fraser University, has determined the
genetic sequencing of 16 mosquitoes (Anopheles
genus)--the sole carriers of human malaria--providing new insight
into how they adapt to humans as primary hosts of the disease.

Their findings have been published in the Science Express, an
electronic publication of selected papers of the journal Science.

SFU mathematician Cedric Chauve and his student, Ashok Rajaraman, used
computational methods to reconstruct ancestral mosquito genomes and analyze
their chromosomal evolution over the past hundred million years. Their hope is
to understand how chromosomes evolved and to unravel potential adaptation
mechanisms that may be related to malaria transmission. They also hope to
determine the genetic differences between these species and others that are
merely bothersome and not toxic.

While only mosquitoes belonging to the Anopheles genus species
transmit human malaria, not all species within the genus, or even all members
of each vector species, are efficient malaria carriers. "This suggests an
underlying genetic/genomic plasticity that results in a variation of key traits
determining transmission capacity within the genus," says Chauve.

He adds: "This is a very exciting project because there is no way we
could sequence the genomes of long-dead ancestral mosquitoes species, without
precious data from current species that was supplied by the biological
team."

The multidisciplinary team consisted of over 100 biologists, immunologists,
infectious disease specialists, computational mathematicians and geneticists
from around the world.

While advances in malaria control have met with successes, the sequencing
of these 16 new genomes will contribute to further understanding the genomic
adaptability of mosquitoes in transmitting malaria.







Story Source:

The above story is based on materials provided by Simon
Fraser University. Note: Materials may be edited for content and length.







Journal Reference:

1.    S. Mok, E. A. Ashley, P. E. Ferreira, L.
Zhu, Z. Lin, T. Yeo, K. Chotivanich, M. Imwong, S. Pukrittayakamee, M. Dhorda,
C. Nguon, P. Lim, C. Amaratunga, S. Suon, T. T. Hien, Y. Htut, M. A. Faiz, M.
A. Onyamboko, M. Mayxay, P. N. Newton, R. Tripura, C. J. Woodrow, O. Miotto, D.
P. Kwiatkowski, F. Nosten, N. P. J. Day, P. R. Preiser, N. J. White, A. M.
Dondorp, R. M. Fairhurst, Z. Bozdech.Population transcriptomics of human
malaria parasites reveals the mechanism of artemisinin resistance. Science,
2014; DOI:10.1126/science.1260403

http://www.sciencedaily.com/releases/2014/12/141223132540.htm

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