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Mengapa strain baru HIV menyebar perlahan-lahan ?
Kebanyakan epidemi HIV masih didominasi oleh strain pertama yang memasuki populasi tertentu . Penelitian baru menawarkan penjelasan mengapa pencampuran global varian HIV sangat lambat ...read more
Why do new
strains of HIV spread slowly?
Date:
February 5, 2015
Source:
PLOS
Summary:
Most HIV epidemics are
still dominated by the first strain that entered a particular population. New
research offers an explanation of why the global mixing of HIV variants is so
slow.
..................
most HIV epidemics are
still dominated by the first strain that entered a particular population. New
research published in PLOS Computational Biology offers an explanation of why the
global mixing of HIV variants is so slow.
Researchers from Eötvös Loránd University; Bence Ferdinandy, Dr Viktor
Müller, and colleagues, analyzed simulated epidemics to understand how distinct
HIV virus strains spreading in the same population compete and interfere with
each other.
The authors show that once a strain of HIV has established a stable
epidemic, it can slow down the invasion of secondary strains into the
population. The primary factor is because individuals infected with the first
HIV strain survive for a relatively long time and are resilient to
'superinfection' from a second strain. The individuals effectively impose
'roadblocks' for the spread of invader strains in the network of sexual
contacts.
The results imply that the HIV variants that dominate the global epidemic
today may not be the most transmissible strains: they may simply have been the
'luckiest', picked up by chance to ride the first wave of expansion from the
epicenter of the pandemic in Central Africa.
More transmissible strains are likely to exist or be created by mutation
and recombination, and these strains may eventually outgrow the current
variants, a warning that the pandemic is not 'static': it may grow further on a
longer time scale. In contrast, eliminating the epidemic could increase the
risk of emergent HIV lineages from novel cross-species transmissions.
Story Source:
The above story is based on materials provided by PLOS. Note: Materials may be edited
for content and length.
Journal Reference:
1. Bence Ferdinandy, Enys Mones, Tamás
Vicsek, Viktor Müller. HIV Competition Dynamics over Sexual Networks:
First Comer Advantage Conserves Founder Effects. PLOS Computational
Biology, 2015; 11 (2): e1004093 DOI:10.1371/journal.pcbi.1004093
