Asupan vitamin yang berlebihan pada tikus hamil dampak pilihan makanan pada keturunannya--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

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Asupan vitamin yang berlebihan pada tikus  hamil  dampak pilihan makanan pada keturunannya

Sebuah model tikus telah digunakan untuk melihat bagaimana  asupan vitamin di atas persyaratan ( A , D , E , dan K ) berdampak pada perkembangan otak dan perilaku  keturunan  . Selama kehamilan banyak wanita mengkonsumsi diet kualitas yang lebih baik , tetapi juga cenderung menggunakan suplemen vitamin , yang dikombinasikan  melebihi kebutuhan asupan vitamin , ...read more

Excessive
vitamin intake in pregnant rats impacts food choices in offspring

Date:

March 19, 2015

Source:

Canadian Science
Publishing (NRC Research Press)

Summary:

A rat model has been
used to see how maternal intake of above-requirement vitamins (A, D, E, and K)
impact offspring's brain development and behavior. During pregnancy many women
consume better quality diets, but are also likely to use vitamin supplements,
which combined may exceed vitamin intake requirements, authors warn.

.......................

A research group at the
Department of Nutritional Sciences at the University of Toronto, Faculty of
Medicine has been using a rat model to see how maternal intake of
above-requirement vitamins (A, D, E, and K) impact offspring's brain
development and behaviour. Some of their findings were published today in the
journal Applied Physiology, Nutrition, and
Metabolism.

Much research on vitamins focuses on prevention of deficiencies and the
toxicity of very high intakes. However, little has been done on the effect of
intakes above requirements as may be common in current diets because of the
mandatory fortification of food to prevent deficiencies, discretionary
additions of nutrients to foods (such as cereals), and an increased use of
health foods and vitamin supplements. During pregnancy many women consume
better quality diets, but are also likely to use vitamin supplements, which
combined may exceed vitamin intake requirements.

Fat soluble vitamins have distinct roles in fetal growth and development
and this study's objective was to determine the effects of a high fat soluble
vitamin diet during pregnancy on body weight gain, food intake and preference
for palatable solutions in male Wistar rat offspring. This results showed
little effect on weight gain and food intake but did find that brain
development and food preference were affected.

According to Dr. Harvey Anderson, principal investigator and a co-author of
the study, the research showed that high-vitamin maternal diets affected
hedonic pathways regulating food preference in the offspring. For example, the
preference for sweetness was decreased; meaning the pups drank less of a sugar
solution if their mothers were on the high vitamin diets. Thus, it seems
consumption of these vitamins above requirements needed for healthy brains may
impact offspring's dietary food preferences and potentially other associated
behaviours.

"While these data provide novel information on the fundamental role of
fat soluble vitamins in brain development, the rat brain developmental stages
are not the same as in the human," explains Dr. Anderson, a co-author of
this research study. "Nevertheless, it is clear we know little about the
effect of vitamins when taken above requirements on brain development."

The application to human mothers and their offspring remains to be
determined.

The article "A gestational diet high in fat soluble vitamins alters
expression of genes in 1 brain pathways and reduces sucrose preference, but not
food intake, in Wistar male rat offspring" by Sanchez-Hernandez et al. was
published in the journal Applied Physiology, Nutrition, and Metabolism.







Story Source:

The above story is based on materials provided by Canadian Science Publishing (NRC
Research Press). Note: Materials may be edited for content and length.







Journal Reference:

1.    Diana Sanchez-Hernandez, Abraham N.
Poon, Ruslan Kubant, Hwanki Kim, Pedro S.P. Huot, Clara E. Cho, Emanuela
Pannia, Zdenka Pausova, G. Harvey Anderson.A gestational diet high in
fat-soluble vitamins alters expression of genes in brain pathways and reduces
sucrose preference, but not food intake, in Wistar male rat offspring. Applied
Physiology, Nutrition, and Metabolism, 2015; 1 DOI: 10.1139/apnm-2014-0480

http://www.sciencedaily.com/releases/2015/03/150319080400.htm

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