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Sistem cadangan yang membantu mempertahankan hati selama krisis telah ditemukan

Sistem antioksidan yang membantu mempertahankan hati ketika sistem lain hilang atau dikompromikan telah ditemukan oleh para ilmuwan ....read more

Backup system
that helps sustain liver during crisis discovered

Date:

March 20, 2015

Source:

Montana State
University

Summary:

An antioxidant system
that helps sustain the liver when other systems are missing or compromised has
been discovered by scientists.

...........................

scientists from Montana
State University and Sweden have discovered an antioxidant system that helps
sustain the liver when other systems are missing or compromised.

Like a generator kicking in when the power fails or an understudy taking
the stage when a lead actor is sick, the newly found system steps up during a
crisis. It's fueled by methionine, an amino acid that can't be manufactured in
the body and doesn't come from herbal teas or supplements. People get it only
by eating protein.

"This is an important finding," said Ed Schmidt, a professor in
MSU's Department of Microbiology and Immunology and co-author of a newly
published study in Nature Communications. "It tells us about
humans and all living things. It's an alternative way to maintain the balance
you need in your cells to be alive."

Schmidt and his collaborators at the Karolinska Institute published their
findings March 20 in Nature Communications, a scientific journal
affiliated with the international journal, Nature. Nature
Communications covers all topics in physics, chemistry, earth sciences
and biology. The Karolinska Institute is one of Europe's largest and most
distinguished medical universities.

Some vitamins and supplements act as antioxidants, Schmidt said. They help
protect cells from the damage that can lead to aging, cancers and inflammatory
diseases. However, vitamins and supplements can't replace two known natural
systems in liver cells: the thioredoxin and glutathione systems.

To investigate further, Schmidt's lab generated mice whose livers lacked
key components of both systems. The mice were not robust. They were on the
brink of failure, Schmidt said. And yet they survived.

Pursuing the mystery, the researchers found the third antioxidant system
and said it has broad implications for health issues in humans. They said
methionine was a surprising source of its power.

"Methionine, a sulfur-containing amino acid that is required in our
diet so our cells can make proteins, is also a potent, but previously
unrecognized antioxidant that, unlike any other antioxidant tested to date, can
sustain the liver when the two other systems are absent or compromised,"
Schmidt said.

"It was well-known, hiding in the shadows," Schmidt continued.
"It wasn't until we removed the two powerful universal systems and found
that the liver would survive that we recognized the role of this third
system."

Methionine is found in high levels in eggs, meat, fish, Brazil nuts, sesame
seeds and cereal grains.

"There is plenty of it in a normal balanced diet," Schmidt said.
"It's only in extreme cases where people are deprived of dietary protein,
or possibly when they are exposed to some toxins, that this could be a
problem."







Story Source:

The above story is based on materials provided by Montana State University. The original article was written by
Evelyn Boswell. Note: Materials may be edited for content and length.







Journal Reference:

1.    Sofi Eriksson, Justin R. Prigge, Emily
A. Talago, Elias S.J. Arnér, Edward E. Schmidt. Dietary methionine can
sustain cytosolic redox homeostasis in the mouse liver. Nature
Communications, 2015; 6: 6479 DOI: 10.1038/ncomms7479

http://www.sciencedaily.com/releases/2015/03/150320133114.htm

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