Herpesvirus mengaktifkan RIG - I reseptor untuk menghindari sistem kekebalan tubuh--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

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Herpesvirus  mengaktifkan RIG - I reseptor untuk menghindari sistem kekebalan tubuh

Menggunakan virus herpes , immunologists molekuler telah menemukan proses seluler yang mengaktifkan pertahanan tubuh terhadap patogen , yang bisa memiliki implikasi untuk mengembangkan obat-obatan untuk meningkatkan kekebalan seseorang terhadap infeksi . Beberapa infeksi virus herpes menyebabkan kanker ....read more

Herpesvirus
activates RIG-I receptor to evade body's immune system

Date:

April 2, 2015

Source:

University of Southern
California - Health Sciences

Summary:

Using herpesvirus,
molecular immunologists have discovered a cellular process that activates a critical
immune defense against pathogens, which could have implications for developing
drugs to bolster one's immunity to infection. Some herpesvirus infections lead
to cancer.

.......................

using herpesvirus,
molecular immunologists from the University of Southern California (USC) Norris
Comprehensive Cancer Center have discovered a cellular process that activates a
critical immune defense against pathogens, which could have implications for
developing drugs to bolster one's immunity to infection. Some herpesvirus
infections lead to cancer.

Led by Pinghui Feng, Ph.D., associate professor of molecular microbiology
and immunology at the Keck School of Medicine of USC, the team found that
herpesvirus proteins activate retinoic acid-induced gene I (RIG-I) by removal
of an amino group from the glutamine and asparagine amino acids through a
process called deamidation. RIG-I is a cellular receptor that recognizes RNA
derived from invading pathogens. Prior to this study, it was unclear whether
RIG-I -- whose activation is central to the body's innate immune defense
response -- could be activated by a component other than viral RNA. This is the
first example wherein host immune defense is activated by an enzymatic
activity, implying that deamidation can be a highly regulated process,
reshaping the conventional notion that deamidation is a non-specific process
associated with protein decay. The team also identified the first bona-fide
enzyme that causes protein deamidation in eukaryotes.







Story Source:

The above story is based on materials provided by University of Southern California
- Health Sciences. Note: Materials may be edited for content and length.







Journal Reference:

1.    Shanping He, Jun Zhao, Shanshan Song,
Xiaojing He, Arlet Minassian, Yu Zhou, Junjie Zhang, Kevin Brulois, Yuqi Wang,
Jackson Cabo, Ebrahim Zandi, Chengyu Liang, Jae U. Jung, Xuewu Zhang,
Pinghui Feng. Viral Pseudo-Enzymes Activate RIG-I via Deamidation to
Evade Cytokine Production. Molecular Cell, 2015; 58 (1): 134
DOI: 10.1016/j.molcel.2015.01.036

http://www.sciencedaily.com/releases/2015/04/150402183534.htm

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