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Jaringan jantung ditanam di substrat  ' sutra laba-laba ' 

Rekayasa genetik serat dari protein spidroin , yang merupakan bahan konstruksi untuk jaring laba-laba , telah terbukti menjadi substrat yang sempurna untuk budidaya sel jaringan jantung , temuan sekelompok peneliti . Budidaya organ dan jaringan dari sel-sel pasien adalah bleeding edge  penelitian medis - metode regeneratif dapat memecahkan masalah penolakan transplantasi . Namun, itu cukup sulit untuk menemukan bingkai yang cocok , atau substrat , untuk menumbuhkan pada sel-sel , kata peneliti....read more

Cardiac tissue
grown on 'spider silk' substrate

Date:

April 10, 2015

Source:

Moscow Institute of
Physics and Technology

Summary:

Genetically engineered
fibers of the protein spidroin, which is the construction material for spider
webs, has proven to be a perfect substrate for cultivating heart tissue cells,
a group of researchers has found. The cultivation of organs and tissues from a
patient’s cells is the bleeding edge of medical research – regenerative methods
can solve the problem of transplant rejection. However,it’s quite a challenge
to find a suitable frame, or substrate, to grow cells on, researchers say.

...........................

genetically engineered
fibers of the protein spidroin, which is the construction material for spider
webs, has proven to be a perfect substrate for cultivating heart tissue cells,
MIPT researchers found. They discuss their findings in an article that has
recently come out in the journal PLOS ONE.

The cultivation of organs and tissues from a patient's cells is the
bleeding edge of medical research -- regenerative methods can solve the problem
of transplant rejection. However,it's quite a challenge to find a suitable frame,
or substrate, to grow cells on. The material should be non-toxic and elastic
andshould not be rejected by the body or impede cell growth. A group of
researchers led by Professor Konstantin Agladze, who heads the Laboratory of
the Biophysics of Excitable Systems at MIPT, works on cardiac tissue
engineering. The group has been cultivating fully functional cardiac tissues,
able to contract and conduct excitation waves, from cells called
cardiomyocytes. Previously, the group used synthetic polymeric nanofibers but
recently decided to assay another material -- electrospunfibers of spidroin,
the cobweb protein. Cobweb strands are incredibly lightand durable. They're
five times stronger than steel, twice more elastic than nylon, and are capable
of stretching a third of their length. The structure of spidroin molecules that
make up cobweb drag lines is similar to that of the silk protein, fibroin, but
is much more durable.

Researchers would normally use artificial spidroin fiber matrices as a
substrate to grow implants like bones, tendons and cartilages, as well as
dressings. Professor Agladze's team decided to find out whether a spidroin
substrate derived from genetically modified yeast cells can serve to grow
cardiac cells.

For this purpose, they seeded isolated neonatal rat cardiomyocytes on fiber
matrices. During the experiment, the researchers monitored the growth of the
cells and tested their contractibility and the ability to conduct electric
impulses, which are the main features of normal cardiac tissue.

The monitoring, carried out with the help of a microscope and fluorescent
markers, showed that within three to five days a layer of cells formed on the
substrate that were able to contract synchronously and conduct electrical
impulses just like the tissue of a living heart would.

"We can answer positively all questions we put at the beginning of
this research project," Professor Agladze says. "Cardiac tissue cells
successfully adhere to the substrate of recombinant spidroin; they grow forming
layers and are fully functional, which means they can contract
coordinately."







Story Source:

The above story is based on materials provided by Moscow Institute of Physics and
Technology. Note: Materials may be edited for content and length.







Journal Reference:

1.    Alexander Teplenin, Anna
Krasheninnikova, Nadezhda Agladze, Konstantin Sidoruk, Olga Agapova, Igor
Agapov, Vladimir Bogush, Konstantin Agladze.Functional Analysis of the
Engineered Cardiac Tissue Grown on Recombinant Spidroin Fiber Meshes. PLOS
ONE, 2015; 10 (3): e0121155 DOI:10.1371/journal.pone.0121155

http://www.sciencedaily.com/releases/2015/04/150410113555.htm

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