virus Zika langsung menginfeksi sel-sel otak dan mematikan deteksi sistem
Date:
June 4, 2016
Source:
UT Southwestern Medical Center
Summary:
peneliti melaporkan dalam sebuah studi baru, nyamuk virus Zika terkait dengan masalah neurologis microcephaly dan lainnya pada bayi yang baru lahir dari ibu yang terkena dampak langsung yang menginfeksi sel-sel progenitor otak yang ditakdirkan untuk menjadi neuron.
......................
nyamuk virus Zika terkait dengan microcephaly dan masalah
neurologis lainnya pada bayi yang baru lahir dari ibu yang
terkena dampak langsung yang
menginfeksi sel-sel progenitor otak yang ditakdirkan
untuk menjadi neuron, peneliti UT Southwestern Medical Center melaporkan dalam
sebuah penelitian yang diterbitkan secara online dalam Cell Reports.
Tim peneliti menggunakan strain Zika yang saat ini berdampak Amerika, dan menemukan bahwa virus menginfeksi sekitar 20 persen dari sel rata-rata, menghindar deteksi sistem kekebalan tubuh, dan terus mereplikasi untuk berminggu minggu .
"Sistem selular kami mempelajari cermin dari patologi menemukan dalam jaringan otak bayi yang terkena dan akan berharga untuk lebih memahami bagaimana Zika menyebabkan masalah yang berhubungan dengan otak yang parah. Sistem ini juga dapat berfungsi sebagai platform untuk menguji terapi baru yang menargetkan virus, "kata Dr John Schoggins, Asisten Profesor Mikrobiologi di UT Southwestern dan penulis senior studi tersebut.
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Zika virus
directly infects brain cells and evades immune system detection, study shows
Date:
June 4, 2016
Source:
UT Southwestern Medical Center
Summary:
The mosquito-borne
Zika virus linked to microcephaly and other neurological problems in newborns
of affected mothers directly infects the brain progenitor cells destined to
become neurons, researchers report in a new study.
......................
The mosquito-borne Zika virus linked to microcephaly and other neurological
problems in newborns of affected mothers directly infects the brain progenitor
cells destined to become neurons, UT Southwestern Medical Center researchers
report in a study published online in Cell Reports.
The team of
researchers used a strain of Zika currently impacting the Americas, and found
that the virus infects about 20 percent of cells on average, evades immune
system detection, and continues to replicate for weeks.
"The cellular
system we studied mirrors what pathologists are finding in the brain tissue of
affected infants and will be valuable for further understanding how Zika causes
severe brain-related problems. The system may also serve as a platform for
testing new therapies targeting the virus," said Dr. John Schoggins,
Assistant Professor of Microbiology at UT Southwestern and senior author of the
study.
Zika can be spread by
infected mosquitos or through sexual intercourse. In adults, the symptoms are
generally mild and include fever, rash, joint pain, and red eyes. However, Zika
virus can cause a serious birth defect called microcephaly, and other severe
neurological effects such as eye problems, hearing loss, and impaired growth in
infants born to women who contracted the virus when pregnant, according to the
Centers for Disease Control and Prevention (CDC).
The CDC's website
lists a series of unanswered questions about the virus that the World Health
Organization (WHO) has declared a public health emergency of international
concern. The unanswered questions include when during pregnancy the infection
may harm the fetus and how the virus affects individual pregnancies.
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website CDC berisi serangkaian pertanyaan yang belum terjawab tentang virus dimana Organisasi Kesehatan Dunia ( WHO ) telah menyatakan keadaan darurat kesehatan masyarakat yang menjadi perhatian internasional . Pertanyaan yang belum terjawab termasuk bila selama kehamilan infeksi dapat membahayakan janin dan bagaimana virus mempengaruhi kehamilan individu
"There was a
suggestion that the detrimental effects of the virus might be linked to its
ability to infect brain cells, specifically the progenitor cells that give rise
to neurons," said Dr. Schoggins, a Nancy Cain and Jeffrey A. Marcus
Scholar in Medical Research, in Honor of Dr. Bill S. Vowell.
"We showed that
neural progenitors can be infected by a strain of Zika virus that is currently
infecting people in the Americas," Dr. Schoggins said. "We found that
the virus kills some neural progenitor cells, but not all. Other cells survive
the infection, and surprisingly, continue to replicate the virus for many
weeks. In addition, it appears that Zika virus does not stimulate much of an
immune response."
Story Source:
The above post is
reprinted from materials provided by UT Southwestern Medical Center. Note: Materials may be edited
for content and length.
Journal Reference:
1.
Natasha W. Hanners, Jennifer L. Eitson, Noriyoshi Usui,
R. Blake Richardson, Eric M. Wexler, Genevieve Konopka, John W.
Schoggins. Western Zika Virus in Human Fetal Neural Progenitors
Persists Long Term with Partial Cytopathic and Limited Immunogenic Effects. Cell
Reports, 2016; DOI: 10.1016/j.celrep.2016.05.075