penelitian
tingkat zinc yang tinggi , batu ginjal
Date:
June 28, 2016
Source:
UCSF Benioff Children's Hospital Oakland
Summary:
Sebuah studi baru penyebab batu ginjal telah mengungkapkan bahwa seng tingkat tinggi
dalam tubuh dapat berkontribusi untuk pembentukan batu ginjal. batu ginjal keras, massa
mineral sering bergerigi mengkristal yang terbentuk di ginjal. Beberapa batu ginjal sangat
kecil dan melewati tubuh tanpa ketahuan.. batu yang lebih besar mungkin terjebak
di saluran kemih, bagaimanapun, menyebabkan sakit parah dan darah dalam urin.
..............................
David Killilea, PhD, seorang ilmuwan staf di Rumah Sakit Anak
Oakland Research Institute (Chori) – cababg penelitian Rumah Sakit UCSF Benioff Anak Oakland
- turut menulis studi mengenai penyebab batu ginjal. Penelitian dilakukan oleh
University of California, San Francisco (UCSF), bekerja sama dengan
Buck Institute untuk Penelitian Aging di Marin County dan
Chori. Diterbitkan di journal ilmiah PLOS ONE, penelitian ini mengungkapkan
bahwa tingkat tinggi seng dalam tubuh dapat berkontribusi untuk pembentukan batu ginjal.
batu ginjal keras , massa mineral bergerigi mengkristal yang terbentuk di ginjal.
Beberapa batu ginjal sangat kecil dan melewati tubuh tanpa ketahuan. batu yang l
ebih besar mungkin terjebak di saluran kemih, bagaimanapun,
menyebabkan sakit parah dan darah dalam urin.
..............................
....................................
high zinc levels, kidney stones,batu ginjal,urinary tract, mineral mengkristal, darah dalam urin,zinc ,kidney stones ,batu ginjal ,Children's Hospital Oakland
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Research links high zinc levels, kidney stones
Date:
June 28, 2016
Source:
UCSF Benioff Children's Hospital Oakland
Summary:
A new study into the causes of kidney stones has revealed that high levels
of zinc in the body may contribute to kidney stone formation. Kidney stones are
hard, often jagged masses of crystalized minerals that form in the kidney. Some
kidney stones are very small and pass through the body without even being
noticed. Larger stones may get stuck in the urinary tract, however, causing
severe pain and blood in the urine.
..............................
David Killilea, PhD, a staff scientist
at Children's Hospital Oakland Research Institute (CHORI) -- the research arm
of UCSF Benioff Children's Hospital Oakland -- co-authored a study into the
causes of kidney stones. The study was conducted by the University of California,
San Francisco (UCSF), in collaboration with the Buck Institute for Research on
Aging in Marin County and CHORI. Published in the scientific journalPLOS ONE, the study revealed that high levels of zinc in the body may contribute to
kidney stone formation.
Kidney stones are hard, often jagged masses of crystalized minerals that
form in the kidney. Some kidney stones are very small and pass through the body
without even being noticed. Larger stones may get stuck in the urinary tract,
however, causing severe pain and blood in the urine.
According to the National Institutes of Health (NIH), kidney stones are one
of the most common disorders of the urinary tract, affecting nearly 10 percent
of the U.S. population. Each year in the U.S., people suffering with kidney
stones make over a million visits to health care providers, including over
300,000 visits to emergency rooms due to the pain. While kidney stones are more
common in adults, they also are becoming increasingly common in infants,
children, and teenagers from all races and ethnicities.
"Nearly 90 percent of kidney stones are calcium-based, but we really
don't know what causes those stones to form," says Dr. Killilea. "In
the past, urologists recommended limiting the amount of calcium in the diet to
help prevent the formation of kidney stones, but that did not turn out to be
very useful. So we wanted to learn what other factors might contribute to the
formation of kidney stones."
The lead author of the study, Thomas Chi, MD, an assistant professor of medicine
in the UCSF Department of Urology, approached Buck Institute researchers to
participate in the study because of their experience in using fruit flies to
model various diseases. Dr. Chi also approached Dr. Killilea to participate in
the study because of his expertise in minerals.
The first step was to recognize what others had taken for granted.
"Years ago, researchers noticed that fruit flies produced little
crystal 'granules' in their primitive kidney-like structures, but that finding
had been mostly ignored," Dr. Killilea explains. "Only
recently have we found that these granules are similar in some ways to kidney
stones in people. Fruit flies are easily managed in the laboratory, and we can
manipulate their genetics and diet. We started screening the genes that might
play a role in calcification, and we came across a gene that plays a role in
metabolizing zinc. At the same time, I was analyzing the fly granules to see
what was in them, and I found relatively high levels of zinc. The way these results
came together was a nice surprise!"
Dr. Killilea stresses that the results of the study are still new, so it is
too early to know about the impact of zinc levels on human kidney stone
formation.
"This study's results do not mean that zinc is bad for you-in fact,
quite the opposite," he says. "Zinc is an essential element
in the human diet. It is well known that people with a zinc deficiency have
immune systems that don't function as well, and that might make kidney stone disease
worse. It is only very high levels of zinc that might be a problem.
With the fruit flies, large doses of zinc caused them to produce stones
faster and to produce bigger stones. People should not avoid zinc, but we need
to determine what the optimal levels of zinc might be, especially in people at
risk for stone disease. That information might eventually give us tools to
treat or even prevent kidney stone formation."
According to Dr. Killilea, a number of other factors can also contribute to
an increased risk for developing kidney stones, including stress, inflammation,
lack of exercise, obesity, and dehydration. Children in particular may be
sensitive to dietary influences, such as the consumption of sugary drinks.
"An increased consumption of sugary drinks can contribute to both obesity
and dehydration," he notes. "Sugary drinks are loaded with
'empty calories' and also can be dehydrating."
The NIH confirms that the prevalence of kidney stones has been rising in
the U.S. over the past 30 years. Researchers observe that many kidney
specialists have reported seeing more children with kidney stones in recent
years. In fact, a study published in the November 2014 issue of The Journal of
Urology® by researchers at Children's Hospital of Philadelphia showed that the
incidence of kidney stones in children has increased by approximately 6 to 10
percent over the past 25 years. Kidney stones that form during childhood have a
similar composition to those that form in adulthood, the study noted.
"We really need more research on kidney stone development in
children," Dr. Killilea says. "Growing children need an
adequate amount of zinc to stay healthy, but there has not been a lot of work
on figuring out what level of zinc is too high."
Some general recommendations for preventing kidney stones-for both children
and adults-include staying hydrated, limiting salt intake, and avoiding sugary
or caffeinated beverages.
"This study was a very big project that would have been nearly
impossible to complete without the collaboration among UCSF, CHORI, and the
Buck Institute," Dr. Killilea notes. "The affiliation of
UCSF Benioff Children's Hospital Oakland, CHORI, and UCSF in San Francisco has
promoted more projects where we can collaborate on research and services to
benefit children's lives in the San Francisco Bay Area."
Story Source:
The above post is reprinted from materials provided
by UCSF
Benioff Children's Hospital Oakland. Note: Materials may
be edited for content and length.