T-REC NEWS 4 U: hamil

Pedoman direvisi pada pengurangan risiko , pilihan pengobatan untuk penyakit tromboemboli pada kehamilan--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

10.10

thromboembolic disease

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Pedoman direvisi pada pengurangan risiko , pilihan pengobatan untuk penyakit tromboemboli pada kehamilan

Saran untuk mencegah dan mengobati tromboemboli vena ( VTE ) selama kehamilan , kelahiran dan setelah melahirkan diuraikan dalam dua pedoman baru  direvisi  . VTE jarang pada kehamilan atau dalam 6 minggu pertama postnatal dan risiko absolut sekitar 1 dari 1.000 kehamilan . Hal ini dapat terjadi pada setiap tahap kehamilan , tetapi saat risiko tertinggi adalah 6 minggu pertama setelah kelahiran , ketika risiko meningkat 20 kali lipat .....read more

Revised
guidelines on reducing risk, treatment options for thromboembolic disease in
pregnancy

Date:

April 16, 2015

Source:

Wiley

Summary:

Advice on preventing
and treating venous thromboembolism (VTE) during pregnancy, birth and following
delivery is outlined in two new revised guidelines. VTE is uncommon in
pregnancy or in the first 6 weeks postnatally and the absolute risk is around 1
in 1,000 pregnancies. It can occur at any stage in pregnancy, but the time of
the highest risk is the first 6 weeks following birth, when the risk increases
20-fold.

.........................

advice on preventing and
treating venous thromboembolism (VTE) during pregnancy, birth and following
delivery is outlined in two new revised guidelines published by the Royal
College of Obstetricians and Gynaecologists (RCOG) and launched at the RCOG
World Congress in Brisbane, Australia.

VTE refers to the formation of a clot within veins. This can occur anywhere
in the venous system, but the predominant sites are in the vessels of the leg
(giving rise to deep vein thrombosis (DVT)) and in the lungs (resulting in a
pulmonary embolism (PE)).

The Green-top Guidelines provide information, based on clinical evidence,
to assist clinicians with both the prevention and treatment of VTE in pregnant
women, a condition which remains the leading direct cause of maternal death in
the UK.

VTE is uncommon in pregnancy or in the first 6 weeks postnatally and the
absolute risk is around 1 in 1,000 pregnancies. It can occur at any stage in
pregnancy, but the time of the highest risk is the first 6 weeks following
birth, when the risk increases 20-fold.

Risk factors include previous VTE or thrombophilia (a tendency to form
blood clots), obesity, increased maternal age, immobility and long-distance
travel, admission to hospital during pregnancy and other comorbidities such as
heart disease, inflammatory bowel disease and pre-eclampsia.

Additional risk factors occurring during the first trimester of pregnancy
include hyperemesis gravidarum, ovarian hyperstimulation and IVF pregnancy.
Caesarean section is also a risk factor.

The guidelines emphasise that all women should undergo a thorough
assessment for VTE in early pregnancy or pre-pregnancy and again intrapartum or
immediately postpartum.

Any woman with risk factors should be considered for prophylactic
low-molecular-weight-heparin (LMWH), an injection administered to thin the
blood. The duration of treatment depends on the number of risk factors a woman
has. It may be offered both antenatally and after the baby is born.

In addition, women with previous VTE must be offered pre-pregnancy
counselling. A prospective management plan for VTE should also be made,
including appropriate treatment to be offered as early as possible and a
careful history documented.

The guidance on treating VTE focuses on the acute management of the
condition and highlights the signs and symptoms, including leg pain and
swelling, lower abdominal pain, shortness of breath, chest pain, coughing blood
and collapse.

Any woman presenting with signs and symptoms suggestive of VTE should be
tested for the condition immediately and offered treatment with
low-molecular-weight heparin (LMWH). All hospitals should have a protocol for
the diagnosis of suspected VTE, with the involvement of a multi-disciplinary
team of obstetricians, radiologists, physicians and haematologists.

Professor Catherine Nelson-Piercy, lead author of the guidance on
preventing thromboembolism says: "Venous thromboembolism is rare in
pregnancy and with prompt recognition can be treated effectively. This guidance
provides clinicians with accurate scientific-based guidelines on the risk
factors for VTE, as well as on how to prevent and treat the condition.

"It is vital that VTE is discussed with all women who are at risk and
the reasons for individual treatment recommendations must also be
explained."

Dr Andrew Thomson, lead author of the guideline on treating thromboembolism
and co-Chair of the RCOG Guidelines Committee says: "Previous editions of
these guidelines have been credited with a reduction in the number of women
dying from thromboembolism during their pregnancy or in the postnatal period in
the UK. Nonetheless, thromboembolism remains an important cause of maternal
morbidity and mortality in our country.

"These updated guidelines provide new evidence about risk factors for
thrombosis in pregnancy and strategies that should be employed to reduce the
chances of a thrombosis occurring. Furthermore, the guidelines provide updated
information on the way women with a suspected thrombosis should be investigated
and treated."

Story Source:

The above story is based on materials provided by Wiley. Note: Materials may be edited
for content and length.

http://www.sciencedaily.com/releases/2015/04/150416132334.htm

Asupan vitamin yang berlebihan pada tikus hamil dampak pilihan makanan pada keturunannya--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

05.49

vitamin

Asupan vitamin yang berlebihan pada tikus  hamil  dampak pilihan makanan pada keturunannya

Sebuah model tikus telah digunakan untuk melihat bagaimana  asupan vitamin di atas persyaratan ( A , D , E , dan K ) berdampak pada perkembangan otak dan perilaku  keturunan  . Selama kehamilan banyak wanita mengkonsumsi diet kualitas yang lebih baik , tetapi juga cenderung menggunakan suplemen vitamin , yang dikombinasikan  melebihi kebutuhan asupan vitamin , ...read more




Excessive
vitamin intake in pregnant rats impacts food choices in offspring

Date:

March 19, 2015

Source:

Canadian Science
Publishing (NRC Research Press)

Summary:

A rat model has been
used to see how maternal intake of above-requirement vitamins (A, D, E, and K)
impact offspring's brain development and behavior. During pregnancy many women
consume better quality diets, but are also likely to use vitamin supplements,
which combined may exceed vitamin intake requirements, authors warn.

.......................

A research group at the
Department of Nutritional Sciences at the University of Toronto, Faculty of
Medicine has been using a rat model to see how maternal intake of
above-requirement vitamins (A, D, E, and K) impact offspring's brain
development and behaviour. Some of their findings were published today in the
journal Applied Physiology, Nutrition, and
Metabolism.

Much research on vitamins focuses on prevention of deficiencies and the
toxicity of very high intakes. However, little has been done on the effect of
intakes above requirements as may be common in current diets because of the
mandatory fortification of food to prevent deficiencies, discretionary
additions of nutrients to foods (such as cereals), and an increased use of
health foods and vitamin supplements. During pregnancy many women consume
better quality diets, but are also likely to use vitamin supplements, which
combined may exceed vitamin intake requirements.

Fat soluble vitamins have distinct roles in fetal growth and development
and this study's objective was to determine the effects of a high fat soluble
vitamin diet during pregnancy on body weight gain, food intake and preference
for palatable solutions in male Wistar rat offspring. This results showed
little effect on weight gain and food intake but did find that brain
development and food preference were affected.

According to Dr. Harvey Anderson, principal investigator and a co-author of
the study, the research showed that high-vitamin maternal diets affected
hedonic pathways regulating food preference in the offspring. For example, the
preference for sweetness was decreased; meaning the pups drank less of a sugar
solution if their mothers were on the high vitamin diets. Thus, it seems
consumption of these vitamins above requirements needed for healthy brains may
impact offspring's dietary food preferences and potentially other associated
behaviours.

"While these data provide novel information on the fundamental role of
fat soluble vitamins in brain development, the rat brain developmental stages
are not the same as in the human," explains Dr. Anderson, a co-author of
this research study. "Nevertheless, it is clear we know little about the
effect of vitamins when taken above requirements on brain development."

The application to human mothers and their offspring remains to be
determined.

The article "A gestational diet high in fat soluble vitamins alters
expression of genes in 1 brain pathways and reduces sucrose preference, but not
food intake, in Wistar male rat offspring" by Sanchez-Hernandez et al. was
published in the journal Applied Physiology, Nutrition, and Metabolism.







Story Source:

The above story is based on materials provided by Canadian Science Publishing (NRC
Research Press). Note: Materials may be edited for content and length.







Journal Reference:

1.    Diana Sanchez-Hernandez, Abraham N.
Poon, Ruslan Kubant, Hwanki Kim, Pedro S.P. Huot, Clara E. Cho, Emanuela
Pannia, Zdenka Pausova, G. Harvey Anderson.A gestational diet high in
fat-soluble vitamins alters expression of genes in brain pathways and reduces
sucrose preference, but not food intake, in Wistar male rat offspring. Applied
Physiology, Nutrition, and Metabolism, 2015; 1 DOI: 10.1139/apnm-2014-0480

http://www.sciencedaily.com/releases/2015/03/150319080400.htm

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Pedoman direvisi pada pengurangan risiko , pilihan pengobatan untuk penyakit tromboemboli pada kehamilan--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

Asupan vitamin yang berlebihan pada tikus hamil dampak pilihan makanan pada keturunannya--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

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