Enzim dalam produk kosmetik dapat bertindak sebagai alergen melalui kulit--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

11.31

kosmetik

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Enzim dalam produk kosmetik dapat bertindak sebagai alergen melalui kulit

Papain adalah enzim industry   protein – degrading penting  yang digunakan , misalnya, dalam industri makanan dan kosmetik . Ketika manusia atau hewan bersentuhan dengan papain , ada hasil reaksi alergi yang kuat dari kulit  , temuan para ilmuwan  ...read more

Enzyme in
cosmetic products can act as allergen via the skin

Date:

April 10, 2015

Source:

Medical University of
Vienna

Summary:

Papain is an important
industrial protein-degrading enzyme that is used, for example, in the food and
cosmetic industries. When humans or animals come in contact with papain, strong
allergic reactions of the skin can be the result, as scientists have found out.

.........................

papain is an important
industrial protein-degrading enzyme that is used, for example, in the food and
cosmetic industries. When humans or animals come in contact with papain, strong
allergic reactions of the skin can be the result, as scientists from the Messerli
Research Institute of the University of Veterinary Medicine Vienna, the Medical
University of Vienna, and the University of Vienna have found out. Their study
was published in the Journal of Investigative Dermatology.

Papain is found naturally in papaya and is often referred to as a
"plant-based pepsin" in reference to the digestive enzyme pepsin that
is present in the stomach. Erika Jensen-Jarolim, Head of the Department of
Comparative Medicine at the Messerli Research Institute, and her team
researched the effect of papain directly on the skin of mice as well as on skin
cells in the petri dish. The cosmetic industry uses papain in exfoliating
treatments to remove dead surface skin. There even are enzyme-based shampoos
for house pets to clean the fur and make it easier to brush.

How papain induces allergic reactions

Skin consists of several layers joined via cellular connections called
"tight junctions." First authors Caroline Stremnitzer and Krisztina
Manzano-Szalai and the project team showed that papain induces a breakdown of
these cell-cell junctions. On the skin, papain results in a loss of the barrier
function. "After just a short period of time, papain increased vascular
permeability and inflammatory cells infiltrated the skin," Jensen-Jarolim
explains. Around two weeks after being exposed to papain, the researchers found
antibodies to papain in the mice. These immunoglobulins are the cause of the
allergic reaction toward the enzyme. "Exposed mice not only experienced a
loss of the barrier function of the skin, but also had a specific allergic
sensitization toward papain. The animals developed an allergy," says
allergy expert Jensen-Jarolim.

Caution is called for with papain-containing products

But the permeation of the skin barrier does not appear to be a prerequisite
for sensitization toward papain. "The enzyme remains allergenic even when
its enzymatic function has been blocked," explains Jensen-Jarolim. The
disruption to the skin barrier, she says, is essential for the infiltration of
other allergens and bacteria. In humans and in animals, diseases of the skin
such as atopic dermatitis, commonly referred to as eczema, involve an increased
permeability of the skin with a heightened risk for bacterial, fungal, or viral
colonisation. Besides genetic factors, allergenic enzymes from external sources
may also contribute to the symptoms. It is striking that papain has an enormous
structural similarity with one of the most important house dust mite allergens.
The authors conclude that sensitization toward these house dust mite allergens
follows the same principle. "People with sensitive skin as well as small
children should avoid the enzyme (EC Number 3.4.22.2) as much as possible and observe the
ingredients declaration for consumer products as regulated by EU Directive
2000/13/EC," says Jensen-Jarolim.







Story Source:

The above story is based on materials provided by Medical
University of Vienna.Note: Materials may be edited for content and length.







Journal Reference:

1.    Caroline Stremnitzer, Krisztina
Manzano-Szalai, Anna Willensdorfer, Philipp Starkl, Mario Pieper, Peter König,
Michael Mildner, Erwin Tschachler, Ursula Reichart, Erika Jensen-Jarolim. Papain
Degrades Tight Junction Proteins of Human Keratinocytes In Vitro and Sensitizes
C57BL/6 Mice via the Skin Independent of its Enzymatic Activity or TLR4
Activation. Journal of Investigative Dermatology, 2015;
DOI: 10.1038/jid.2015.58

http://www.sciencedaily.com/releases/2015/04/150410083304.htm

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Hasil Kosmetik yang baik , safety dengan Liposculpture dari Pinggul , Bagian sisi dan Paha--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

11.09

Liposculpture

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More info :

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minat gabung : ( menerima keanggotaan seluruh kota dan daerah di Indonesia )

08995557626

..................................

KSE – KOMUNITAS SATWA EKSOTIK – EXOTIC PETS COMMUNITY-- INDONESIA

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www.facebook.com/groups/komunitassatwaeksotik/

 KSE = KOMUNITAS SATWA EKSOTIK

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KAMI ADA DI TIAP KOTA DI INDONESIA 

DETAIL TENTANG KSE-----KLIK : www.komunitassatwaeksotik-pendaftaran.blogspot.com 

GABUNG......... ( menerima keanggotaan seluruh kota dan daerah di Indonesia )

HUBUNGI   :  089617123865

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Hasil Kosmetik yang baik , safety  dengan Liposculpture dari Pinggul , Bagian sisi dan Paha

Dua dekade pengalaman oleh ahli bedah plastik senior dalam berbagai belahan dunia menunjukkan hasil kosmetik yang sangat baik dan tingkat komplikasi yang rendah dengan liposculpture dari pinggul , panggul , dan paha , ....read more

Good Cosmetic
Results, Safety with Liposculpture of the Hips, Flanks and Thighs

Date:

January 15, 2015

Source:

Wolters Kluwer Health:
Lippincott Williams and Wilkins

Summary:

Two decades of
experience by senior plastic surgeons in different parts of the world show
excellent cosmetic results and low complication rates with liposculpture of the
hips, flanks, and thighs, reports a new paper.

..................

two decades of
experience by senior plastic surgeons in different parts of the world show
excellent cosmetic results and low complication rates with liposculpture of the
hips, flanks, and thighs, reports a paper in Plastic and Reconstructive Surgery
-- Global Open®, the
official open-access medical journal of the American Society of Plastic
Surgeons (ASPS).

Plastic surgeons Yixin Zhang, MD, PhD, of Shanghai JiaoTong University and
Manuel Francesco Castello, MD, of Clinica Villa Salaria, Rome, report on their
joint experience using modern liposuction techniques for sculpting the lower
body -- hips, flanks, and thighs. They conclude, "Based on our 20 years of
experience and observations on three-dimensional liposuction, we can suggest it
a reliable method with proven results."

Modern Liposculpture Technique Leads to Excellent Results

Drs. Zhang and Castello and coauthors describe and analyze their technique
and outcomes of lower-body liposculpture in more than 4,000 patients.
Liposculpture "is a very sophisticated method that goes beyond the simple
aspiration of adipose tissue [fat] and allows the surgeon to modify the shape
of the body and recontour the profile," the researchers write.

A key aspect of the technique is not only to remove underlying fat, but
also to promote and guide skin retraction after fat removal. This includes
careful thinning of the skin in order to allow it to better retract and adapt
to the new shape. "The skin should no longer be considered a passive
element during superficial liposuction, but instead as an active, structural
and dynamic constituent," the authors believe.

Drs. Zhang and Castello outline each step of their procedure: from initial
patient evaluation, to preoperative marking of the skin, through patient
preparation and liposuction technique. Postoperative care includes compression
garments and bandages to guide skin adaptation to the carefully sculpted
underlying fat.

"If performed correctly, three-dimensional liposuction of trunk, hips
and thighs can yield very satisfying outcomes because of the excellent contour
and enhanced skin retraction provided by the thin cutaneous [skin] adipose
flap," the researchers write. They note that their cosmetic results have
been well-maintained during follow-up, including in patients with pregnancies
or weight loss or gain.

Complications rates were low, with only one serious complication -- an
infection that responded to antibiotics -- in more than 4,000 patients. Fifty
patients had postoperative seromas (fluid collections) which resolved after repeated
drainage. Other patients had minor cosmetic issues that were later
"touched up" with simple procedures.

Drs. Zhang and Castello and coauthors believe their experience demonstrates
the excellent cosmetic results and safety record of three-dimensional
liposculpture of the hips, flanks, and thighs -- and highlights the role of
techniques aimed at promoting good skin adaptation to the new shape. They
conclude, "A careful application of the technique combined with an
accurate surgical planning, a thorough preoperative explanation of real
expectations and post-operative care are crucial."










Story Source:

The above story is based on materials provided by Wolters
Kluwer Health: Lippincott Williams and Wilkins. Note: Materials may be edited
for content and length.










Journal Reference:

1.    Yi Xin Zhang, Davide Lazzeri, Luca
Grassetti, Alessandro Silvestri, Aurelia Trisliana Perdanasari, Sheng Han,
Matteo Torresetti, Giovanni di Benedetto, Manuel Francisco Castello. Three-dimensional
Superficial Liposculpture of the Hips, Flank, and Thighs. Plastic
& Reconstructive Surgery Global Open, 2015; 1 DOI:10.1097/GOX.0000000000000241

http://www.sciencedaily.com/releases/2015/01/150115102647.htm

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