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Ekstrak tumbuhan melawan  tumor otak

Silibinin dari  biji milk thistle bisa menjadi cara baru , strategi pengobatan non - invasif untuk Penyakit Cushing . penyakit Cushing  , tidak menjadi meragukan  dengan Sindrom Cushing , yang disebabkan oleh tumor di kelenjar hipofisis di otak ....read more

Plant extract
fights brain tumor

Date:

February 11, 2015

Source:

Max-Planck-Gesellschaft

Summary:

Silibinin from milk
thistle seeds could be a novel, non-invasive treatment strategy for Cushing
Disease. Cushing Disease, not to be confused with Cushing's Syndrome, is caused
by a tumor in the pituitary gland in the brain.

..................

cushing Disease, not to
be confused with Cushing's Syndrome, is caused by a tumour in the pituitary
gland in the brain. The tumour secrets increased amounts of the stress hormone
adrenocorticotropin (ACTH) followed by cortisol release from the adrenal glands
leading to rapid weight gain, elevated blood pressure and muscular weakness.
Patients are prone to osteoporosis, infections and may show cognitive
dysfunction or even depression. In 80 to 85 % of the patients the tumour can be
removed by uncomfortable brain surgery. For inoperable cases, there is
currently only one targeted therapy approved which unfortunately causes intense
side effects such as hyperglycemia in more than 20% of the patients.

Scientists around Günter Stalla, endocrinologist at the Max Planck Institute
of Psychiatry in Munich, now discovered in cell cultures, animal models and
human tumour tissue that a harmless plant extract can be applied to treat
Cushing Disease. "Silibinin is the major active constituent of milk
thistle seeds. It has an outstanding safety profile in humans and is already
used for the treatment of liver disease and poisoning," explains Marcelo
Paez-Pereda, leading scientist of the current study published in the scientific
journal Nature Medicine. After silibinin treatment, tumour cells
resumed normal ACTH production, tumour growth slowed down and symptoms of
Cushing Disease disappeared in mice.

In 2013, the Max Planck scientists filed a patent on a broad family of
chemical and natural compounds, including silibinin, to treat pituitary
tumours. Compared to humans, of which only 5.5 in 100,000 people worldwide
develop Cushing Disease, this condition is very common in several pets. For
example, 4 % of dogs and even 7 % of horses suffer from Cushing Disease. Thus,
the researchers now plan to test special formulations with a very pure
substance and slow release of the active component silibinin in clinical
trials.

Silibinin: Mode of action

"We knew that Cushing Disease is caused by the release of too much
ACTH. So we asked ourselves what causes this over production and how to stop
it," says Paez-Pereda. In their first experiments the researchers found
tremendously high amounts of the heat shock protein 90 (HSP90) in tumour tissue
from patients with Cushing Disease. In normal amounts HSP90 helps to correctly
fold another protein, the glucocorticoid receptor which in turn inhibits the
production of ACTH. "As there are too many HSP90 molecules in the tumour
tissue, they stick to the glucocorticoid receptor," explains Paez-Pereda.
"We found that silibinin binds to HSP90 thus allowing glucocorticoid
receptor molecules to dissolve from HSP90. With silibinin we might have
discovered a non-invasive treatment strategy not only for the rare Cushing
Disease but also for other conditions with the involvement of glucocorticoid
receptors such as lung tumours, acute lymphoblastic leukemia or multiple
myeloma," concludes Paez-Pereda.







Story Source:

The above story is based on materials provided by Max-Planck-Gesellschaft. Note: Materials may be edited
for content and length.







Journal Reference:

1.    Mathias Riebold, Christian Kozany, Lee
Freiburger, Michael Sattler, Michael Buchfelder, Felix Hausch, Günter K Stalla,
Marcelo Paez-Pereda. A C-terminal HSP90 inhibitor restores
glucocorticoid sensitivity and relieves a mouse allograft model of Cushing
disease. Nature Medicine, 2015; DOI:10.1038/nm.3776

http://www.sciencedaily.com/releases/2015/02/150211124022.htm

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