Jamur karnivora mengungkapkan trik kekebalan tubuh manusia : Bagaimana jalan ke sel kanker--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

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Jamur karnivora mengungkapkan trik kekebalan tubuh manusia : Bagaimana jalan ke sel kanker

jamur tiram memiliki rahasia menarik : Mereka makan laba-laba dan cacing gelang . Dan mereka melakukannya dengan menggunakan protein yang dapat menjadi  jalan mereka ke dalam sel , .... . Ini adalah trik yang sel kekebalan tubuh kita yang  juga digunakan untuk melindungi kita , menghancurkan sel yang terinfeksi , sel-sel kanker , dan bakteri ....read more

Carnivorous
mushroom reveals human immune trick: How we punch our way into cancer cells

Date:

February 5, 2015

Source:

PLOS

Summary:

Edible oyster
mushrooms have an intriguing secret: They eat spiders and roundworms. And they
do so using proteins that can punch their way into cells, leaving tidy but
deadly holes. It's a trick that our immune cells also use to protect us,
destroying infected cells, cancerous cells, and bacteria.

......................

edible oyster mushrooms
have an intriguing secret: they eat spiders and roundworms. And they do so
using proteins that can punch their way into cells, leaving tidy but deadly
holes. It's a trick that our immune cells also use to protect us, destroying
infected cells, cancerous cells, and bacteria.

Research publishing January 27th in the open access journal PLOS
Biology by an international team, led by the ARC Imaging Centre at
Monash University in Melbourne and Birkbeck College in London, reveals the
molecular process behind the punch. Using synchrotron light and cryo-electron
microscopy, they've visualised the action of a protein called pleurotolysin --
opening the way to new drug targets and new tools for medicine, agriculture,
genetic engineering and nano-engineering. By taking molecular snapshots, which
they've turned into a movie, the team have been able to observe the
hole-punching protein as it latches onto, and puts a hole in the target cell --
either killing the cell directly or providing a passage for other proteins that
can kill it.

"I never believed I'd be able to see these proteins in action,"
says the paper's lead author Dr Michelle Dunstone. "It's an amazing
mechanism, and also amazing that we now have the technology to see these
hole-punching proteins at work."

Using a combination of molecular imaging, along with biophysical and
computational experiments, the team have been able to show the way the
pleurotolysin protein moves, unfolding and refolding to punch the hole in the
target cell. And in doing so, they've also found its Achilles heel. So now they
can look at how to block the hole punching mechanism, or introduce it to new
places where this function is desirable.

"The next step is to take what we've learned from the oyster mushroom
proteins and compare them with equivalent proteins across nature," says
Michelle. "We're particularly interested in this family of proteins in
humans, especially perforin, which we believe will behave in the same
way."

There are potential applications in medicine: dampening immune responses in
people with autoimmune disease; stopping listeria escaping our immune cells;
and preventing malaria from infecting the liver. In agriculture these proteins
could be introduced into plants and crops, helping them to fight off attacks
from pests, and reducing the need for pesticides.

"These results are the culmination of over seven years work by from
researchers on opposite sides of the world, including thousands of hours by our
first authors Natalya Lukoyanova and Stephanie Kondos," says Michelle.

"We still have a lot of work to do before our ideas reach the clinic
or industry but seeing how the machinery works is an important step
forward," says Birkbeck College's Professor Helen Saibil, co-lead author
on the paper.







Story Source:

The above story is based on materials provided by PLOS. Note: Materials may be edited
for content and length.







Journal Reference:

1.    Natalya Lukoyanova, Stephanie C. Kondos,
Irene Farabella, Ruby H. P. Law, Cyril F. Reboul, Tom T. Caradoc-Davies,
Bradley A. Spicer, Oded Kleifeld, Daouda A. K. Traore, Susan M. Ekkel, Ilia
Voskoboinik, Joseph A. Trapani, Tamas Hatfaludi, Katherine Oliver, Eileen M.
Hotze, Rodney K. Tweten, James C. Whisstock, Maya Topf, Helen R. Saibil,
Michelle A. Dunstone. Conformational Changes during Pore Formation by
the Perforin-Related Protein Pleurotolysin. PLOS Biology, 2015;
13 (2): e1002049 DOI: 10.1371/journal.pbio.1002049

http://www.sciencedaily.com/releases/2015/02/150205142913.htm







nN�>/p)@tyle='font-family:"Helvetica","sans-serif";
mso-fareast-font-family:"Times New Roman";color:#070809;mso-fareast-language:
IN'>. Note: Materials may be edited for content and length.










Journal Reference:

1.    Amanda L. Thompson, Andrea
Monteagudo-Mera, Maria B. Cadenas, Michelle L. Lampl and M. A.
Azcarate-Peril. Milk- and solid-feeding practices and daycare
attendance are associated with differences in bacterial diversity, predominant
communities, and metabolic and immune function of the infant gut microbiome. Frontiers
in Cellular and Infection Microbiology, 2015 DOI:10.3389/fcimb.2015.00003

http://www.sciencedaily.com/releases/2015/02/150205174625.htm

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