Operasi bariatric tampaknya memotong risiko untuk terkait asma serius--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

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Operasi bariatric tampaknya memotong risiko untuk terkait asma serius

Operasi bariatrik dapat secara signifikan mengurangi risiko serangan asma - juga disebut eksaserbasi - pada pasien obesitas dengan asma ,...... Laporan ini adalah yang pertama untuk menemukan bahwa penurunan berat badan yang signifikan dapat mengurangi kejadian terkait asma serius .....read more

Bariatric
surgery appears to cut risks for serious asthma-related events

Date:

March 13, 2015

Source:

Massachusetts General
Hospital

Summary:

Bariatric surgery can
significantly reduce the risk of asthma attacks -- also called exacerbations --
in obese patients with asthma, research shows. The report is the first to find
that significant weight reduction can reduce serious asthma-associated events.

...........................

A study led by
Massachusetts General Hospital (MGH) investigators suggests that bariatric
surgery can significantly reduce the risk of asthma attacks -- also called
exacerbations -- in obese patients with asthma. Their report, published online
in the Journal of Allergy and Clinical
Immunology, is the first to find that significant weight reduction
can reduce serious asthma-associated events.

"We found that, in obese patients with asthma, the risk of emergency
department visits and hospitalizations for asthma exacerbations decreased by
half in the two years after bariatric surgery," says Kohei Hasegawa, MD,
MPH, MGH Department of Emergency Medicine, the lead author of the study.
"Although previous studies of non-surgical weight loss interventions
failed to show consistent results regarding asthma risks, our result strongly
suggests that the kind of significant weight loss that often results from
bariatric surgery can reduce adverse asthma events."

Both obesity and asthma are serious public health problems at historically
high levels in the U.S., the authors note, and many researchers have associated
obesity with the development of asthma and with an increased risk for asthma
exacerbations. While previous studies investigating whether weight loss could
reduce asthma risks showed little or no benefit, participants in those studies
lost only modest amounts of weight. The current study was designed to
investigate whether bariatric surgery -- regarded as the most effective option
for morbidly obese patients -- might have a greater effect on asthma-associated
risks.

Using available databases reflecting the utilization of health services in
California, Florida and Nebraska -- all three of which give access to
deidentified information on individual patients -- the research team identified
2,261 obese patients with asthma who underwent bariatric surgery from 2007 to
2009 and for whom information covering the two years before and after their
surgery was available. This design, in which participants essentially act as
their own controls, reduces the need to control for additional factors -- such
as age, gender, genetic background and physical activity -- that might bias the
results.

The analysis showed that, during the two years prior to surgery, around 22
percent of the studied patients had at least one emergency department (ED)
visit or hospitalization in each one-year period. In the two years after
surgery, only 11 percent needed an ED visit or hospital admission in each year.
Looking at hospitalization alone showed an even greater risk reduction, from
around 7 percent per year to less than 3 percent. A comparison with patients
who had other types of abdominal surgery showed that non-bariatric procedures
had no impact on asthma exacerbation risk.

While the mechanism by which a significant weight loss can reduce
asthma-associated risks is unknown, studies have linked obesity to increased
inflammation, higher prevalence of gastroesophageal reflux disease, and
physical changes in the airway -- all of which could contribute to asthma
severity. Hasegawa notes that a reduction or reversal of these mechanisms by
bariatric surgery is plausible.

"The databases we had access to did not include the actual amount of
weight lost by these patients, but it is well documented that bariatric surgery
results in substantial weight loss, averaging around 35 percent of presurgical
weight," he says. "While we can't currently say how much weight loss
would be needed to reduce asthma risks, previous studies of non-surgical
interventions indicate that modest weight loss is not enough."

"Bariatric surgery is a costly procedure that carries its own risks,
factors that may offset the benefits regarding the risk of asthma exacerbation
for some patients," Hasegawa adds. "To decrease asthma-related
adverse events in the millions of obese individuals with asthma, we probably will
need to develop safe, effective non-surgical approaches to achieve major weight
loss."







Story Source:

The above story is based on materials provided by Massachusetts General Hospital.Note: Materials may be edited for
content and length.







Journal Reference:

1.    Kohei Hasegawa, Yusuke Tsugawa, Yuchiao
Chang, Carlos A. Camargo. Risk of an asthma exacerbation after
bariatric surgery in adults. Journal of Allergy and Clinical
Immunology, 2015; DOI: 10.1016/j.jaci.2014.12.1931

http://www.sciencedaily.com/releases/2015/03/150313110430.htm’

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