kapsul vaksin
antraks benar-benar melindungi monyet
dari menghirup Anthrax yang mematikan
Date:
June 27, 2016
Source:
US Army Medical Research Institute of
Infectious Diseases
Summary:
Vaksinasi dengan kapsul anthrax - komponen alami dari bakteri yang menyebabkan
penyakit ini - benar benar melindungi monyet dari infeksi antraks mematikan,
menurut sebuah penelitian. Hasil ini menunjukkan bahwa kapsul anthrax adalah
komponen vaksin yang sangat efektif yang harus dipertimbangkan untuk dimasukkan
dalam vaksin generasi anthrax masa depan.
............................
Vaksinasi dengan kapsul anthrax - komponen alami dari bakteri yang menyebabkan
penyakit ini - benar benar melindungi monyet dari infeksi antraks mematikan,
menurut sebuah penelitian. Hasil ini menunjukkan bahwa kapsul anthrax adalah komponen
vaksin yang sangat efektif yang harus dipertimbangkan untuk dimasukkan dalam
vaksin generasi anthrax masa depan.
Bacillus anthracis, bakteri yang menyebabkan anthrax, diakui sebagai salah satu
ancaman bioterorisme yang paling signifikan. Ini menghasilkan tiga komponen utama
yang memungkinkan untuk menyebabkan racun penyakit - mematikan, edema racun,
dan kapsul. Selama infeksi anthrax, bakteri menyerang dan tumbuh untuk konsentrasi
tinggi pada tuan rumah. kapsul mengelilingi bakteri dan mencegah dari yang dicerna
dan dihancurkan oleh sel-sel darah putih, sehingga memungkinkan infeksi anthrax
untuk kemajuan. Racun yang diduga bertindak terutama dengan merusak mekanisme
pertahanan alami tubuh.
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Anthrax capsule vaccine completely protects monkeys
from lethal inhalational anthrax
Date:
June 27, 2016
Source:
US Army Medical Research Institute of
Infectious Diseases
Summary:
Vaccination with the anthrax capsule -- a naturally occurring component of
the bacterium that causes the disease -- completely protected monkeys from
lethal anthrax infection, according to a study. These results indicate that
anthrax capsule is a highly effective vaccine component that should be
considered for incorporation in future generation anthrax vaccines.
............................
Vaccination with the anthrax capsule--a
naturally occurring component of the bacterium that causes the
disease--completely protected monkeys from lethal anthrax infection, according
to a study published online this week in the journalVACCINE. These results indicate that anthrax capsule is a highly effective vaccine
component that should be considered for incorporation in future generation
anthrax vaccines.
Bacillus anthracis, the bacterium that causes anthrax, is
recognized as one of the most significant bioterrorism threats. It produces
three main components that allow it to cause disease--lethal toxin, edema
toxin, and capsule. During anthrax infection, the bacterium invades and grows
to high concentrations in the host. The capsule surrounds the bacterium and
prevents it from being ingested and destroyed by the white blood cells, thus
allowing anthrax infection to progress. The toxins are thought to act mainly by
damaging the body's natural defense mechanisms.
Current human vaccines for anthrax are based on the protective antigen
component of the anthrax toxins. Scientists at the U.S. Army Medical Research
Institute of Infectious Diseases (USAMRIID) have extensively studied protective
antigen, demonstrating that protective antigen alone confers protection in
animal challenge studies with both rabbits and monkeys.
However, according to senior author Arthur M. Friedlander, M.D., of
USAMRIID, concerns about reliance on a single antigen--as well as the issue of
protecting against anthrax strains that may be vaccine resistant--have prompted
the search for additional vaccine components. Bacterial capsules are commonly
used in licensed vaccines for other diseases, including certain types of
pneumonia and meningitis.
Friedlander's group had already demonstrated in published studies that the
anthrax capsule plays a role in conferring protection. In their current work,
the team describes testing a higher dose of the capsule vaccine in monkeys
against a lethal aerosol challenge with anthrax spores. All the animals
receiving the capsule vaccine survived while all non-vaccinated animals
succumbed to the disease.
"In the 140-year history of research on anthrax there have been two
previous types of vaccine, the last one licensed in 1970," Friedlander
said. "This new capsule vaccine is expected to work against possible
vaccine-resistant strains of anthrax and to protect individuals who may not
respond optimally to protective antigen alone. In addition, it could be
combined with protective antigen to create a multi-component vaccine that may
enhance the efficacy of protective antigen- based vaccines."
Story Source:
The above post is reprinted from materials provided
by US Army Medical Research Institute of
Infectious Diseases.Note: Materials may be edited for
content and length.
Journal Reference:
1. Donald J.
Chabot, Wilson J. Ribot, Joseph Joyce, James Cook, Robert Hepler, Debbie Nahas,
Jennifer Chua, Arthur M. Friedlander. Protection of rhesus macaques
against inhalational anthrax with a Bacillus anthracis capsule conjugate
vaccine. Vaccine, 2016; DOI:10.1016/j.vaccine.2016.06.031