T-REC NEWS 4 U: asthma

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Studi besar yang menuju selangkah lebih dekat untuk pengobatan asma berat--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

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Studi besar yang menuju selangkah lebih dekat untuk pengobatan asma berat

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Studi besar yang  menuju  selangkah lebih dekat untuk pengobatan  asma berat

Date:

September 9, 2015

Source:

European Lung Foundation

Summary:.

Temuan awal dari studi besar telah membantu mengidentifikasi karakteristik kunci dari asma yang parah , yang akan membantu dengan pengembangan pengobatan baru untuk pasien dengan kondisi tersebut .

........... tulisan  baru yang dipublikasikan secara online dalam European Respiratory Journal , adalah salah satu penilaian terbesar dari orang dewasa dengan asma berat sampai saat ini, melihat beberapa karakteristik termasuk gejala , kualitas hidup pasien dan darah dan pengukuran napas .................more

Major study moves a step closer to treatments for
severe asthma

Date:

September 9, 2015

Source:

European Lung Foundation

Summary:

Initial findings from a major study have
helped identify key characteristics of severe asthma, which will help with the development
of new treatments for patients with the condition.

.........

Initial findings from a major European
study have helped identify key characteristics of severe asthma, which will
help with the development of new treatments for patients with the condition.

The new paper, published online in
the European Respiratory Journal, is one of the largest assessments
of adults with severe asthma to date, looking at several characteristics
including symptoms, patients' quality of life and blood and airway measurements.

Over 30 million adults and children in
Europe suffer from asthma and it is estimated that of these, 4% (approximately
1.2 million people) have severe asthma. People with the disease experience
daily symptoms despite receiving high doses of medical treatment and are more
likely to be admitted to hospital and to require emergency healthcare. This
represents a significant burden on healthcare systems.

The U-BIOPRED (Unbiased BIOmarkers in
PREDiction of respiratory disease outcomes) project, funded by the Innovative
Medicines Initiative (IMI), was established in 2008 to better understand severe
asthma and identify new treatment targets.

This study involved four groups of adult
participants in 11 countries and followed them up for over a year; 311 non-smokers
with severe asthma, 110 smokers and ex-smokers with severe asthma, 88 patients
with milder asthma and 101 healthy volunteers. As part of the study, blood,
urine and sputum (mucus) samples were collected and lung function and other
anatomical tests were performed.

The results found that patients with
severe asthma had more symptoms and exacerbations compared to patients with
mild-moderate disease. Severe asthma patients also reported worse quality of
life and higher levels of anxiety and depression as well as more nasal polyps
(small growths in the nose), acid indigestion and poorer lung function.

A key finding is that although patients
with severe asthma take greater amounts of anti-inflammatory treatment,
including inhaled and oral steroids, they still had higher levels of
inflammation in their airways.

Lead author of the paper Dr Dominick
Shaw, from the University of Nottingham in the UK, said: "This study is
the first to describe severe asthma across such a large cohort. Our findings
are consistent with other recent descriptions of the condition and will enable
us now to identify distinct asthma phenotypes, or subgroups. Once we can break
this condition down into different groups, patients can be swiftly and
accurately diagnosed and individually treated by targeting the mechanisms that
are driving their own disease. Once we can identify these new treatments, we
can lessen the burden of this chronic and debilitating disease."

The U-BIOPRED study will continue to
publish findings from this cohort and a paediatric cohort in the coming months,
including papers due to be presented at the European Respiratory Society's
International Congress including descriptions of the first classification of
severe asthma types using different types of biological data.

Story Source:

The above post is reprinted from materials provided byEuropean Lung
Foundation. Note: Materials may be edited
for content and length.

Journal Reference:

1.
Dominick E. Shaw et al. U-BIOPRED
severe asthma.European Respiratory Journal, September 2015 DOI:10.1183/13993003.00779-2015

http://www.sciencedaily.com/releases/2015/09/150909213414.htm

Operasi bariatric tampaknya memotong risiko untuk terkait asma serius--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

05.53

Bariatric surgery

Operasi bariatric tampaknya memotong risiko untuk terkait asma serius

Operasi bariatrik dapat secara signifikan mengurangi risiko serangan asma - juga disebut eksaserbasi - pada pasien obesitas dengan asma ,...... Laporan ini adalah yang pertama untuk menemukan bahwa penurunan berat badan yang signifikan dapat mengurangi kejadian terkait asma serius .....read more




Bariatric
surgery appears to cut risks for serious asthma-related events

Date:

March 13, 2015

Source:

Massachusetts General
Hospital

Summary:

Bariatric surgery can
significantly reduce the risk of asthma attacks -- also called exacerbations --
in obese patients with asthma, research shows. The report is the first to find
that significant weight reduction can reduce serious asthma-associated events.

...........................

A study led by
Massachusetts General Hospital (MGH) investigators suggests that bariatric
surgery can significantly reduce the risk of asthma attacks -- also called
exacerbations -- in obese patients with asthma. Their report, published online
in the Journal of Allergy and Clinical
Immunology, is the first to find that significant weight reduction
can reduce serious asthma-associated events.

"We found that, in obese patients with asthma, the risk of emergency
department visits and hospitalizations for asthma exacerbations decreased by
half in the two years after bariatric surgery," says Kohei Hasegawa, MD,
MPH, MGH Department of Emergency Medicine, the lead author of the study.
"Although previous studies of non-surgical weight loss interventions
failed to show consistent results regarding asthma risks, our result strongly
suggests that the kind of significant weight loss that often results from
bariatric surgery can reduce adverse asthma events."

Both obesity and asthma are serious public health problems at historically
high levels in the U.S., the authors note, and many researchers have associated
obesity with the development of asthma and with an increased risk for asthma
exacerbations. While previous studies investigating whether weight loss could
reduce asthma risks showed little or no benefit, participants in those studies
lost only modest amounts of weight. The current study was designed to
investigate whether bariatric surgery -- regarded as the most effective option
for morbidly obese patients -- might have a greater effect on asthma-associated
risks.

Using available databases reflecting the utilization of health services in
California, Florida and Nebraska -- all three of which give access to
deidentified information on individual patients -- the research team identified
2,261 obese patients with asthma who underwent bariatric surgery from 2007 to
2009 and for whom information covering the two years before and after their
surgery was available. This design, in which participants essentially act as
their own controls, reduces the need to control for additional factors -- such
as age, gender, genetic background and physical activity -- that might bias the
results.

The analysis showed that, during the two years prior to surgery, around 22
percent of the studied patients had at least one emergency department (ED)
visit or hospitalization in each one-year period. In the two years after
surgery, only 11 percent needed an ED visit or hospital admission in each year.
Looking at hospitalization alone showed an even greater risk reduction, from
around 7 percent per year to less than 3 percent. A comparison with patients
who had other types of abdominal surgery showed that non-bariatric procedures
had no impact on asthma exacerbation risk.

While the mechanism by which a significant weight loss can reduce
asthma-associated risks is unknown, studies have linked obesity to increased
inflammation, higher prevalence of gastroesophageal reflux disease, and
physical changes in the airway -- all of which could contribute to asthma
severity. Hasegawa notes that a reduction or reversal of these mechanisms by
bariatric surgery is plausible.

"The databases we had access to did not include the actual amount of
weight lost by these patients, but it is well documented that bariatric surgery
results in substantial weight loss, averaging around 35 percent of presurgical
weight," he says. "While we can't currently say how much weight loss
would be needed to reduce asthma risks, previous studies of non-surgical
interventions indicate that modest weight loss is not enough."

"Bariatric surgery is a costly procedure that carries its own risks,
factors that may offset the benefits regarding the risk of asthma exacerbation
for some patients," Hasegawa adds. "To decrease asthma-related
adverse events in the millions of obese individuals with asthma, we probably will
need to develop safe, effective non-surgical approaches to achieve major weight
loss."







Story Source:

The above story is based on materials provided by Massachusetts General Hospital.Note: Materials may be edited for
content and length.







Journal Reference:

1.    Kohei Hasegawa, Yusuke Tsugawa, Yuchiao
Chang, Carlos A. Camargo. Risk of an asthma exacerbation after
bariatric surgery in adults. Journal of Allergy and Clinical
Immunology, 2015; DOI: 10.1016/j.jaci.2014.12.1931

http://www.sciencedaily.com/releases/2015/03/150313110430.htm’

Protein yang terkait dengan perkembangan asma--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

06.37

protein

Protein  yang terkait dengan perkembangan asma

Para peneliti telah menghubungkan protein tertentu , CCL28 , untuk pengembangan asma pasca infeksi virus , yang merupakan langkah pertama dalam menghasilkan jenis novel terapi asma yang dirancang untuk mencegah perkembangan asma pasca - virus pada anak-anak .....read more




Protein linked
to development of asthma

Date:

February 20, 2015

Source:

Medical College of
Wisconsin

Summary:

Researchers have
linked a specific protein, CCL28, to the development of post-viral infection
asthma, which is the first step in generating a novel type of asthma therapy
designed to prevent development of post-viral asthma in young children.

....................

researchers at the
Medical College of Wisconsin (MCW) have linked a specific protein to the
development of post-viral infection asthma, which is the first step in
generating a novel type of asthma therapy designed to prevent development of
post-viral asthma in young children.

The findings are published in the Journal of Biological Chemistry.

Brian F. Volkman, PhD, professor of biochemistry; and Mitchell H. Grayson,
MD, associate professor of allergy and immunology; are the lead researchers on
the study.

Asthma is a chronic disease of the airways that affects more than 300
million people worldwide. It is the number one illness leading to school
absences in children, and accounts for more than 1.8 million emergency room
visits annually. There is no cure; all current therapies focus on providing
symptomatic relief and reducing the number and severity of attacks.

"Understanding the molecular mechanisms by which asthma develops and
establishes itself as a chronic disease is key to elucidating alternative and
potentially curative therapies," said Dr. Grayson.

The researchers previously found evidence linking a human chemokine
(protein) called CCL28 to the development of chronic asthma. This study is the
first, however, that examines structural analysis and its impact on disease
development.

"We found that even in the absence of a viral infection, CCL28 can
play a role in the induction of asthma pathology--when the protein is natively
folded. If unfolded, it does not," explained Dr. Volkman. "We propose
that by exploiting the unique structural features of CCL28, potent and specific
CCL28 inhibitors may be developed. This work is the first step in generating a
novel type of asthma therapy that may have the power to prevent development of
post-viral asthma in young children."







Story Source:

The above story is based on materials provided by Medical
College of Wisconsin.Note: Materials may be edited for content and length.







Journal Reference:

1.    Monica A. Thomas, Becky J. Buelow,
Amanda M. Nevins, Stephanie E. Jones, Francis C. Peterson, Rebekah L. Gundry,
Mitchell H. Grayson, Brian F. Volkman.Structure-Function Analysis of CCL28
in the Development of Post-viral Asthma. Journal of Biological
Chemistry, 2015; 290 (7): 4528 DOI:10.1074/jbc.M114.627786

http://www.sciencedaily.com/releases/2015/02/150220133344.htm

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Studi besar yang menuju selangkah lebih dekat untuk pengobatan asma berat--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

Operasi bariatric tampaknya memotong risiko untuk terkait asma serius--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

Protein yang terkait dengan perkembangan asma--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

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