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Gene
clue opens paths to treat child brain cancer
Gene
clue opens paths to treat child brain cancer
Sunday Apr
06, 2014 | Agence France Presse
Genetic
mutations found in brain tumours in children have opened up intriguing avenues
to tackle this lethal form of cancer, researchers said on Sunday.
Investigators
found telltale mutations in a gene called ACVR1, which appears to play a role
in a currently incurable form of childhood brain cancer called diffuse
intrinsic pontine glioma, or DIPG.
The
mutations were found in 20 to 33 percent of DIPG biopsies in three different
studies published in the journal Nature Genetics.
DIPG is the
most aggressive brain tumour in children.
It develops
in the brain stem, which is the seat of basic body functions that keep people
alive, which means that it cannot be removed safely by surgery.
It is the
first time that ACVR1 has been fingered in cancer.
A mutated
form of ACVR1, though, has been identified previously in a rare disorder called
"Stone Man syndrome," in which the body's muscles and tendons
progressively turn to bone.
The work
should also shed light on understanding some of the fundamental mechanisms of
DIPG, including its progression from an early-stage condition, the Institut
Gustave Roussy in Paris, which took part in one of the studies, said in a
statement.
In addition,
"specific inhibitor drugs" are being developed that may be of
potential use against the faulty gene, it added.
Copyright
(2014) AFP. All rights reserved.
This article was distributed through the NewsCred Smartwire. Original
article © Agence France Presse 2014