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Consuming
high-fat diet associated with increased risk of certain types of breast cancer
Consuming
high-fat diet associated with increased risk of certain types of breast cancer
Date:
April 9,
2014
Source:
Oxford University Press USA
Summary:
High total and saturated fat intake were associated
with greater risk of estrogen receptor- and progesterone receptor-positive
breast cancer, and human epidermal growth factor 2 receptor-negative disease,
according to a new study. The authors conclude, "a high-fat diet increases
BC risk and, most conspicuously, that high saturated fat intake increases risk
of receptor-positive disease, suggesting saturated fat involvement in the
etiology of receptor-positive BC."
..........................
High total
and saturated fat intake were associated with greater risk of estrogen
receptor- and progesterone receptor-positive (ER+PR+) breast cancer (BC), and
human epidermal growth factor 2 receptor-negative (HER2-) disease, according to
a new study published April 9 in the Journal
of the National Cancer Institute.
Published
data from epidemiological and case-control studies on the association between
high fat intake and BC risk have been conflicting, which may be attributable to
difficulties obtaining accurate information on fat intake and because of
limited heterogeneity of intake within a specific geographic area from which
the study cohorts live. Furthermore, BC is now classified clinically into
subtypes by ER, PR, and HER2 expression status and each subtype has its own
prognosis and set of risk factors, which may also contribute to the
inconsistencies in the published reports on this relationship.
Sabina
Sieri, Ph.D., from the Epidemiology and Prevention Unit of the Department of
Preventive & Predictive Medicine at Fondazione IRCCS Istituto Nazionale Dei
Tumori in Milan Italy, and colleagues prospectively analyzed data from 10,062
BC patients from the EPIC study with 11.5 years of follow-up. The EPIC cohort
study consisted of 337,327 women living in 10 European countries, which creates
a heterogeneous cohort both in terms of geography-related dietary fat intake
patterns and in terms of molecular subtype. To correct the dietary
questionnaire data for measurement errors, intake data were calibrated with
standardized 24-hour dietary recall interviews on administered to a random
sample of 8% of the cohort. Cox proportional hazard modeling included various
known risk factors as covariables.
The authors
report high total and saturated fat intake were associated with greater risk of
ER+PR+ BC. High saturated fat intake was also associated with greater risk of
HER2- disease. The authors conclude, "a high-fat diet increases BC risk
and, most conspicuously, that high saturated fat intake increases risk of
receptor-positive disease, suggesting saturated fat involvement in the etiology
of receptor-positive BC."
Story
Source:
The above
story is based on materials provided by Oxford
University Press USA. Note: Materials may be edited for content and
length.
Journal
Reference:
- S. Sieri, P. Chiodini, C. Agnoli, V. Pala, F. Berrino, A. Trichopoulou, V. Benetou, E. Vasilopoulou, M.-J. Sanchez, M.-D. Chirlaque, P. Amiano, J. R. Quiros, E. Ardanaz, G. Buckland, G. Masala, S. Panico, S. Grioni, C. Sacerdote, R. Tumino, M.-C. Boutron-Ruault, F. Clavel-Chapelon, G. Fagherazzi, P. H. M. Peeters, C. H. van Gils, H. B. Bueno-de-Mesquita, H. J. van Kranen, T. J. Key, R. C. Travis, K. T. Khaw, N. J. Wareham, R. Kaaks, A. Lukanova, H. Boeing, M. Schutze, E. Sonestedt, E. Wirfalt, M. Sund, A. Andersson, V. Chajes, S. Rinaldi, I. Romieu, E. Weiderpass, G. Skeie, E. Dagrun, A. Tjonneland, J. Halkjaer, K. Overvard, M. A. Merritt, D. Cox, E. Riboli, V. Krogh. Dietary Fat Intake and Development of Specific Breast Cancer Subtypes. JNCI Journal of the National Cancer Institute, 2014; DOI: 10.1093/jnci/dju068
Cite This
Page:
Oxford University Press USA.
"Consuming high-fat diet associated with increased risk of certain types
of breast cancer." ScienceDaily. ScienceDaily, 9 April 2014.
<www.sciencedaily.com/releases/2014/04/140409204417.htm>.
