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Regenerated
esophagus transplanted in rats
Regenerated
esophagus transplanted in rats
Date:
April 15,
2014
Source:
Karolinska Institutet
Summary:
Tissue engineering has been used to construct natural
esophagi, which in combination with bone marrow stem cells have been safely and
effectively transplanted in rats. The study shows that the transplanted organs
remain patent and display regeneration of nerves, muscles, epithelial cells and
blood vessels.
.....................
Tissue engineering has been used to construct natural
oesophagi, which in combination with bone marrow stem cells have been safely
and effectively transplanted in rats. The study, published in Nature
Communications, shows that the transplanted organs remain patent and display
regeneration of nerves, muscles, epithelial cells and blood vessels.
The new
method has been developed by researchers at Karolinska Institutet in Sweden,
within an international collaboration lead by Professor Paolo Macchiarini. The
technique to grow human tissues and organs, so called tissue engineering, has
been employed so far to produce urinary bladder, trachea and blood vessels,
which have also been used clinically. However, despite several attempts, it has
been proven difficult to grow tissue to replace a damaged esophagus.
In this new
study, the researchers created the bioengineered organs by using oesophagi from
rats and removing all the cells. With the cells gone, a scaffold remains in
which the structure as well as mechanical and chemical properties of the organ
are preserved. The produced scaffolds were then reseeded with cells from the
bone marrow. The adhering cells have low immunogenicity which minimizes the
risk of immune reaction and graft rejection and also eliminates the need for
immunosuppressive drugs. The cells adhered to the biological scaffold and
started to show organ-specific characteristics within three weeks.
The cultured
tissues were used to replace segments of the esophagus in rats. All rats
survived and after two weeks the researchers found indications of the major
components in the regenerated graft: epithelium, muscle cells, blood vessels
and nerves.
"We
believe that these very promising findings represent major advances towards the
clinical translation of tissue engineered esophagi," says Paolo
Macchiarini, Director of Advanced center for translational regenerative
medicine (ACTREM) at Karolinska Institutet.
Tissue
engineered organs could improve survival and quality of life for the hundreds
of thousands of patients yearly diagnosed with esophageal disorders such as
cancer, congenital anomalies or trauma. Today the patients' own intestine or
stomach is used for esophageal replacements, but satisfactory function rarely
achieved. Cultured tissue might eliminate this current need and likely improve
surgery-related mortality, morbidity and functional outcome.
Story
Source:
The above
story is based on materials provided by Karolinska Institutet. Note: Materials may be
edited for content and length.
Journal
Reference:
- Sebastian Sjöqvist, Philipp Jungebluth, Mei Ling Lim, Johannes C. Haag, Ylva Gustafsson, Greg Lemon, Silvia Baiguera, Miguel Angel Burguillos, Costantino Del Gaudio, Antonio Beltrán RodrÃguez, Alexander Sotnichenko, Karolina Kublickiene, Henrik Ullman, Heike Kielstein, Peter Damberg, Alessandra Bianco, Rainer Heuchel, Ying Zhao, Domenico Ribatti, Cristián Ibarra, Bertrand Joseph, Doris A. Taylor, Paolo Macchiarini. Experimental orthotopic transplantation of a tissue-engineered oesophagus in rats. Nature Communications, 2014; 5 DOI: 10.1038/ncomms4562
Cite This
Page:
Karolinska Institutet.
"Regenerated esophagus transplanted in rats." ScienceDaily.
ScienceDaily, 15 April 2014.
<www.sciencedaily.com/releases/2014/04/140415112359.htm>.
