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Prenatal
risk factors may put children at risk of developing kidney disease
Prenatal
risk factors may put children at risk of developing kidney disease
Date:
April 17,
2014
Source:
American Society of Nephrology (ASN)
Summary:
Certain prenatal risk factors are associated with the
development of chronic kidney disease in children, according to a study. Future
studies should investigate whether modifying these factors could help protect
children’s kidney health. Risks for certain types of kidney disease may arise
before birth, and researchers suspect that the development of chronic kidney
disease (CKD) may be programmed prenatally. These may include birth weight,
maternal diabetes, and maternal overweight/obesity.
......................
Certain prenatal risk factors are associated with the
development of chronic kidney disease in children, according to a study
appearing in an upcoming issue of the Journal
of the American Society of Nephrology (JASN). Future studies should
investigate whether modifying these factors could help protect children's
kidney health.
Risks for
certain types of kidney disease may arise before birth, and researchers suspect
that the development of chronic kidney disease (CKD) may be programmed
prenatally. Christine Hsu, MD (University of Washington) and her colleagues
sought to determine the association of childhood CKD with prenatal risk
factors, including birth weight, maternal diabetes, and maternal
overweight/obesity.
The
researchers studied 1994 patients with childhood CKD and 20,032 controls
without the disease, and the team linked maternal and infant characteristics in
birth records from 1987 to 2008 to hospital discharge data.
The
prevalence of CKD was 126.7 cases per 100,000 births. Infants with low birth
weight were nearly three times more likely to develop childhood CKD than
infants with normal birth weight. Infants were also at increased risk if their
mothers developed diabetes during pregnancy of if their mothers were overweight
or obese.
"We
hope this research leads to further research on ways to reduce kidney disease
through either early treatment or prevention that might begin even before
birth," said Dr. Hsu. "Previous studies show that strict control of
maternal diabetes significantly reduces the risk of congenital malformations in
children. We hope our work leads to future studies to investigate whether
strict control of maternal diabetes and/or reducing maternal obesity/overweight
reduces childhood CKD."
Story
Source:
The above
story is based on materials
provided by American
Society of Nephrology (ASN). Note: Materials may be edited for
content and length.
Journal
Reference:
- C. W. Hsu, K. T. Yamamoto, R. K. Henry, A. J. De Roos, J. T. Flynn. Prenatal Risk Factors for Childhood CKD. Journal of the American Society of Nephrology, 2014; DOI: 10.1681/ASN.2013060582
Cite This
Page:
American Society of Nephrology
(ASN). "Prenatal risk factors may put children at risk of developing
kidney disease." ScienceDaily. ScienceDaily, 17 April 2014.
<www.sciencedaily.com/releases/2014/04/140417191129.htm>.
