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Diets rich in antioxidant resveratrol fail to reduce deaths, heart
disease or cancer
Date:
May 12, 2014
Source:
Johns Hopkins Medicine
Summary:
A study of Italians who consume a diet rich in
resveratrol -- the compound found in red wine, dark chocolate and berries --
finds they live no longer than and are just as likely to develop cardiovascular
disease or cancer as those who eat or drink smaller amounts of the antioxidant.
...................
A study of Italians who consume a diet rich in resveratrol
-- the compound found in red wine, dark chocolate and berries -- finds they
live no longer than and are just as likely to develop cardiovascular disease or
cancer as those who eat or drink smaller amounts of the antioxidant.
"The
story of resveratrol turns out to be another case where you get a lot of hype
about health benefits that doesn't stand the test of time," says Richard
D. Semba, M.D., M.P.H., a professor of ophthalmology at the Johns Hopkins
University School of Medicine and leader of the study described May 12 in JAMA
Internal Medicine. "The thinking was that certain foods are good for
you because they contain resveratrol. We didn't find that at all."
Despite the
negative results, Semba says, studies have shown that consumption of red wine,
dark chocolate and berries does reduce inflammation in some people and still
appears to protect the heart. "It's just that the benefits, if they are
there, must come from other polyphenols or substances found in those
foodstuffs," he says. "These are complex foods, and all we really
know from our study is that the benefits are probably not due to
resveratrol."
The new
study did not include people taking resveratrol supplements, though few studies
thus far have found benefits associated with them.
Semba is
part of an international team of researchers that for 15 years has studied the
effects of aging in a group of people who live in the Chianti region of Italy.
For the current study, the researchers analyzed 24 hours of urine samples from
783 people over the age of 65 for metabolites of resveratrol. After accounting
for such factors as age and gender, the people with the highest concentration
of resveratrol metabolites were no less likely to have died of any cause than
those with no resveratrol found in their urine. The concentration of
resveratrol was not associated with inflammatory markers, cardiovascular
disease or cancer rates.
Semba and
his colleagues used advanced mass spectrometry to analyze the urine samples.
The study
participants make up a random group of people living in Tuscany where
supplement use is uncommon and consumption of red wine -- a specialty of the
region -- is the norm. The study participants were not on any prescribed diet.
Resveratrol
is also found in relatively large amounts in grapes, peanuts and certain
Asiatic plant roots. Excitement over its health benefits followed studies
documenting anti-inflammatory effects in lower organisms and increased lifespan
in mice fed a high-calorie diet rich in the compound.
The
so-called "French paradox," in which a low incidence of coronary
heart disease occurs in the presence of a high dietary intake of cholesterol
and saturated fat in France, has been attributed to the regular consumption of
resveratrol and other polyphenols found in red wine.
Story
Source:
The above
story is based on materials provided by Johns Hopkins Medicine.
Note: Materials may be edited for content and length.
Journal
Reference:
- Richard D. Semba, Luigi Ferrucci, Benedetta Bartali, Mireia UrpÃ-Sarda, Raul Zamora-Ros, Kai Sun, Antonio Cherubini, Stefania Bandinelli, Cristina Andres-Lacueva. Resveratrol Levels and All-Cause Mortality in Older Community-Dwelling Adults. JAMA Internal Medicine, 2014; DOI: 10.1001/jamainternmed.2014.1582
Cite This
Page:
Johns Hopkins Medicine. "Diets
rich in antioxidant resveratrol fail to reduce deaths, heart disease or
cancer." ScienceDaily. ScienceDaily, 12 May 2014.
<www.sciencedaily.com/releases/2014/05/140512214128.htm>.
