Pemetaan racun kadal memungkinkan untuk mengembangkan obat baru--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

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Pemetaan racun kadal  memungkinkan untuk mengembangkan obat baru

Kadal dan reptil lainnya biasanya tidak dianggap berbisa , tetapi sejumlah spesies kadal sebenarnya memproduksi dan menggunakan racun . Kadal berbisa yang paling klasik tidak diragukan lagi adalah  gila monster  - kadal  bertubuh berat  . Sebagai yang pertama di dunia , sekelompok peneliti telah membuat deskripsi komprehensif dari protein dalam racun yang dapat membuktikan menjadi relevan sehubungan dengan pengembangan  jenis obat baru ....more

Mapping lizard venom makes it possible
to develop new drugs

Date:

February 24, 2015

Source:

Aarhus University

Summary:

Lizards and other reptiles are not normally considered venomous, but a
number of lizard species actually do produce and use venom. The most classic
venomous lizard is no doubt the gila monster -- a heavy-bodied lizard. As the
first in the world, a group of researchers has made a comprehensive description
of the proteins in the venom which can prove to be relevant in connection with
developing new types of drugs.

.......................

Gila and beaded lizards are the classic venomous lizards. However, it was
recently shown that venom is also used by a number of other species, such as
the awesome Komodo monitors -- the largest present-day lizards. Lizard venom
has much in common with snake venom, and the current theory is that the venom
production apparatus in lizards and snakes is related, but has developed in
different directions. Gila and beaded lizards mainly use venom to defend themselves,
while snakes use their venom to attack prey. However, the composition of venom
proteins is similar in lizards and snakes.

Potential in venom

Venom research is a large field, especially due to the pharmaceutical
potential of the venom proteins. The idea here is that venom proteins are
capable of affecting the body's cells. Excessive amounts can be harmful and
even lethal in some circumstances, but if the right dose is used, the venom
proteins can be used to treat certain diseases. Snake proteins that normally
cause prey to bleed can be used in small doses to treat blood clots, for
example.

In the same way, work is currently being done to develop spider venom
proteins to provide pain relief. The Aarhus researchers focused on gila
lizards, and these are currently being used in pharmaceutical contexts. Gila
lizards produce exendin-4, a small venom protein used in the treatment of
diabetes and obesity, which is a competitor to Victoza® -- produced by Novo
Nordisk.

New venom proteins identified

A method called proteomics was used in the Aarhus study to make the first
overall description of venom proteins in gila lizards. Individual proteins such
as exendin-4 used to be purified from gila lizard venom, and this resulted in a
number of interesting results. However, an overall analysis of all the venom
proteins has not been undertaken before, which therefore made it easy to
overlook the potentially important components in the venom.

Making a comprehensive analysis of the venom protein composition was not an
easy task. "The work was complicated by the fact that the gila lizard
genome hasn't been isolated, and genomes normally provide a map to navigate
when you're using proteomics for protein identifications," says Associate
Professor Kristian Wejse Sanggaard. "We therefore used a more manually
based approach to identify the proteins in the gila lizard venom. This
succeeded, and we've identified nineteen proteins that no one previously knew
existed in the venom," he concludes.

Based on these identifications, the researchers have gained new knowledge
about the function of the venom proteins, and have also gained greater insight
into the evolutionary contexts of venom proteins. In addition, there are now
new proteins that can potentially be used to develop future drugs.







Story Source:

The above story is based on materials provided
by Aarhus University. The original article was written by
Lisbeth Heilesen.Note: Materials may be edited for content and length.







Journal Reference:

1.   
Kristian W. Sanggaard, Thomas F. Dyrlund, Line R. Thomsen, Tania A.
Nielsen, Lars Brøndum, Tobias Wang, Ida B. Thøgersen, Jan J. Enghild. Characterization
of the gila monster (Heloderma suspectum suspectum) venom proteome. Journal
of Proteomics, 2015; 117: 1 DOI: 10.1016/j.jprot.2015.01.004

http://www.sciencedaily.com/releases/2015/02/150224091828.htm

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