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Berat badan lahir yang rendah dikombinasikan dengan gaya hidup dewasa  yang tidak sehat  dapat meningkatkan resiko diabetes tipe 2

Date:

July 21, 2015

Source:

Harvard School of Public Health

Summary:

Orang yang berat badan rendah saat lahir dan memiliki kebiasaan yang tidak sehat sebagai orang dewasa , seperti makan diet gizi buruk atau merokok , mungkin memiliki risiko lebih besar terkena diabetes tipe 2 dibandingkan dengan orang yang lahir pada berat rata-rata yang tinggal dengan  gaya hidup yang sama , menurut sebuah baru studi .

............ " Sebagian besar kasus diabetes tipe 2 dapat dicegah dengan penerapan gaya hidup sehat , tetapi temuan ini menunjukkan bahwa upaya difokuskan pada pengembangan kehidupan awal , seperti meningkatkan gizi bagi ibu hamil , bisa mencegah kasus tambahan , " kata Lu Qi , profesor di Departemen Nutrisi di Harvard Chan School  dan Divisi Channing Jaringan Medicine , Brigham dan Rumah Sakit Wanita , dan penulis senior studi tersebut .

Studi ini muncul secara online 21 Juli 2015 di BMJ .......more

Low birth weight
combined with unhealthy adult lifestyle may increase type 2 diabetes risk

Date:

July 21, 2015

Source:

Harvard School of Public Health

Summary:

People who are a low weight at birth and have unhealthy habits as adults,
such as eating nutritionally poor diets or smoking, may have a greater risk of
developing type 2 diabetes than people born at an average weight who live
similar lifestyles, according to a new study.

......................

People who are a low weight at birth and have unhealthy habits as adults,
such as eating nutritionally poor diets or smoking, may have a greater risk of
developing type 2 diabetes than people born at an average weight who live
similar lifestyles, according to a new study led by researchers from Harvard
T.H. Chan School of Public Health. In the first study to comprehensively assess
how early development interacts with adult behavior to influence type 2
diabetes risk, the researchers found that 18% of cases were attributable to the
combined effect of low birth weight and unhealthy adult lifestyles.

"Most cases of type 2 diabetes could be prevented by the adoption of a
healthier lifestyle, but these findings suggest that efforts focused on early
life development, such as improving nutrition for pregnant women, could prevent
additional cases," said Lu Qi, associate professor in the Department of
Nutrition at Harvard Chan School and Channing Division of Network Medicine,
Brigham and Women's Hospital, and the study's senior author.

The study appears online July 21, 2015 in BMJ.

Diabetes has become a worldwide epidemic, with 4.9 million attributable
deaths in 2014 and an estimated 387 million people living with the disease,
according to the International Diabetes Federation. Type 2 diabetes, which
represents 85-95% of all cases, has been linked to both unhealthy lifestyles
and negative early life development factors, including low birth weight
(defined as less than 5.5 pounds for this study) and prenatal exposure to
malnutrition.

While previous studies have looked at how adult lifestyles may modify early
life risks, few have analyzed the joint effects of early life and unhealthy
lifestyle factors on type 2 diabetes risk.

Qi and colleagues studied health data collected from 149,794 healthy men
and women tracked by three large ongoing trials (Health Professionals Follow-up
Study, Nurses' Health Study, and Nurses' Health Study II) for 20-30 years.
Participants were scored on five lifestyle factors: diet, smoking, physical
activity, alcohol consumption, and body mass index. Those who did not provide
their birth weight were excluded from this analysis.

The researchers documented 11,709 new cases of type 2 diabetes during the
study period. They found that 22% of these cases could be attributed to a lower
birth weight alone, 59% to unhealthy lifestyle alone, and 18% to the
interaction between both factors.

The researchers suggest that if a pregnant woman is poorly nourished it may
cause the fetus to prepare for survival in a resource-scarce environment. When
the adaptive response to prenatal starvation is mismatched with exposure to an
affluent environment later in life, it can increase the risk of type 2 diabetes
in adulthood.

"Our findings suggest that the public health consequences of unhealthy
lifestyles would be larger in low birth weight populations," said Yanping
Li, lead author and research scientist in the Department of Nutrition.
"This is of critical importance in the developing countries undergoing
rapid epidemiologic transition from traditional to Western lifestyles, such as
China and India, where the prevalence of the Western dietary pattern, cigarette
smoking, sedentary activities, obesity, and diabetes has been increasing
dramatically, and low birth weight is still highly prevalent (around 17% in
developing countries)."







Story Source:

The above post is reprinted from materials provided byHarvard
School of Public Health. Note: Materials may be edited for content
and length.







Journal Reference:

1.   
Yanping Li, Sylvia H. Ley, Deirdre K. Tobias, Stephanie E. Chiuve, Tyler J.
VanderWeele, Janet W. Rich-Edwards, Gary C. Curhan, Walter C. Willett, JoAnn E.
Manson, Frank B. Hu, Lu Qi. Birth weight and later life adherence to
unhealthy lifestyles in predicting type 2 diabetes: prospective cohort study. The
BMJ, July 2015 DOI:10.1136/bmj.h3672

http://www.sciencedaily.com/releases/2015/07/150721193851.htm

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