Memanipulasi molekul di otak meningkatkan stress respon , target baru untuk pengobatan depresi--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

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Memanipulasi molekul di otak meningkatkan stress respon  , target baru untuk pengobatan depresi

Date:

July 21, 2015

Source:

UT Southwestern Medical Center

Summary:

Para peneliti melaporkan, Meningkatkan kadar molekul sinyal yang ditemukan di otak secara positif dapat mengubah respon terhadap stres , mengungkapkan target terapi baru yang potensial untuk pengobatan depresi .

............ Penelitian, yang muncul dalam Nature Neuroscience , menetapkan bahwa mengangkat tingkat molekul siklik adenosin monofosfat ( cAMP ) dalam sel-sel otak memiliki dampak positif pada perilaku stres diinduksi pada tikus . Penelitian lain menunjukkan bahwa pasien dengan gangguan depresi mayor sering mengalami gangguan cAMP signaling dan perawatan antidepresan kronis sering menyalakan sistem sinyal ini ....more

Manipulating
molecule in the brain improves stress response, new target for depression
treatment

Date:

July 21, 2015

Source:

UT Southwestern Medical Center

Summary:

Increasing the levels of a signaling molecule found in the brain can
positively alter response to stress, revealing a potential new therapeutic
target for treatment of depression, researchers report.

...............

ncreasing the levels of a signaling molecule found in the brain can
positively alter response to stress, revealing a potential new therapeutic
target for treatment of depression, UT Southwestern Medical Center researchers
said.

The study, which appears in Nature Neuroscience, determined
that elevating levels of the molecule cyclic adenosine monophosphate (cAMP) in
brain cells had a positive impact on stress-induced behaviors in mice. Other
studies have shown that patients with major depressive disorder often have
impaired cAMP signaling and that chronic antidepressant treatments often turn
on this signaling system.

"This is the first step in the development of a treatment for patients
with major depressive disorder using this new strategy," said senior
author Dr. James Bibb, Professor of Psychiatry, and Neurology and
Neurotherapeutics at UT Southwestern.

Major depressive disorder (MDD) may be triggered or exacerbated by severe
or chronic stress. Depression affects more than 120 million people worldwide.
Between 20 percent to 40 percent of people with depression are not helped by
existing therapies, highlighting the need for new treatments and approaches.

The study was supported by the Center for Depression Research and Clinical
Care at UT Southwestern. The Center, established with a $5 million lead gift
from the Hersh Foundation earlier this year, combines basic research,
translational clinical research in genetics, functional brain imaging, and
treatment research across the entire age span, with a special focus on
treatment of resistant, chronic, or recurrent depression.

"These exciting findings could help us develop very novel treatments
to reduce stress response and prevent or treat depression effectively in the
future," said Dr. Madhukar Trivedi, Director of the Center for Depression
Research and Clinical Care, Chief of the Division of Mood Disorders, Professor
of Psychiatry, and holder of the Betty Jo Hay Distinguished Chair in Mental
Health.

The chemical changes occurred in a region of the brain called the nucleus
accumbens, which has a significant role in the processing of motivation,
pleasure, and reward.

Researchers found that levels of cAMP can be elevated by disrupting the
activation of an enzyme called phosphodiesterase-4 (PDE4). Knocking out the
regulatory protein kinase Cdk5 in brain cells disrupted PDE4 function and
elevated cAMP levels. This positively affected behavioral responses of the mice
to stress-inducing experiments.

The researchers then developed a drug-like peptide that selectively blocked
PDE4 function and increased the struggling response of mice to a test of acute
stress commonly used to assess antidepressant efficacy.







Story Source:

The above post is reprinted from materials provided
by UT Southwestern Medical Center. Note:
Materials may be edited for content and length.







Journal Reference:

1.   
Florian Plattner, Kanehiro Hayashi, Adan Hernández, David R Benavides, Tara
C Tassin, Chunfeng Tan, Jonathan Day, Maggy W Fina, Eunice Y Yuen, Zhen Yan,
Matthew S Goldberg, Angus C Nairn, Paul Greengard, Eric J Nestler, Ronald
Taussig, Akinori Nishi, Miles D Houslay, James A Bibb. The role of
ventral striatal cAMP signaling in stress-induced behaviors. Nature
Neuroscience, 2015; DOI: 10.1038/nn.4066

http://www.sciencedaily.com/releases/2015/07/150721150215.htm

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