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Suhu tubuh dapat memicu kematian jantung mendadak

Date:

July 16, 2015

Source:

Simon Fraser University

Summary:

Ketika mempelajari protein yang mendasari sinyal listrik di jantung , dan subjecting  protein  untuk kondisi yang mirip dengan stres latihan , para peneliti telah menemukan bahwa dalam beberapa kasus , suhu dapat menyebabkan perubahan yang memicu aritmia .

........... Pemain sepak bola yang drop death  di tengah-tengah permainan , atau bayi yang meninggal saat tidur sering merupakan korban dari aritmia . Kematian jantung mendadak memiliki beberapa penyebab , termasuk mutasi diwariskan dalam DNA  mempengaruhi struktur dan fungsi protein dalam hati . Simon Fraser University profesor Peter Ruben temukan ketika mempelajari protein yang mendasari sinyal listrik di jantung , dan subjecting  protein untuk kondisi yang mirip dengan stres latihan , dalam beberapa kasus , suhu dapat menyebabkan perubahan yang memicu aritmia ......more

Body temperature
may trigger sudden cardiac death

Date:

July 16, 2015

Source:

Simon Fraser University

Summary:

When studying the proteins that underlie electrical signaling in the heart,
and subjecting those proteins to conditions that are similar to the stress of
exercise, researchers have found that in some cases, temperature can cause
changes that trigger arrhythmia.

............................

Scientists, including SFU professor Peter Ruben, have found that sudden
death caused by cardiac arrhythmia can be triggered by changes in body
temperature. The study is published in the Journal of
Physiology.

The soccer player who drops dead in the middle of a game, or the infant who
dies during sleep is often a victim of arrhythmia. Sudden cardiac death has several
causes, including inheritable mutations in our DNA affecting structure and
function of proteins in the heart. Simon Fraser University professor Peter
Ruben found when studying the proteins that underlie electrical signaling in
the heart, and subjecting those proteins to conditions that are similar to the
stress of exercise, in some cases, temperature can cause changes that trigger
arrhythmia.

According to Ruben, a professor in the Department of Biomedical Physiology
and Kinesiology (BPK), when muscle cells in our hearts contract rhythmically
and in a well-coordinated way, the heart efficiently pumps blood throughout our
bodies. When the rhythmic pumping action is disrupted by an arrhythmia, our
hearts can no longer distribute blood.

In extreme cases, this leads to sudden cardiac death. He adds: "The
electrical signal behind muscle contraction is produced by tiny protein
molecules in the membrane of our heart cells. Temperature fluctuations modify
the way all proteins behave, but some DNA mutations can make proteins
especially sensitive to changes in temperature."

Ruben's team found a protein that is far more sensitive to temperature than
normal. When normal body temperature goes up for example, during exercise, or
goes down during sleep, the affected protein no longer functions normally. The
disrupted protein function causes the electrical signal in our heart to become
erratic, triggering an arrhythmia and, potentially, sudden cardiac death.

The DNA mutation that creates more temperature-sensitive proteins is very
rare, but it can produce deadly results when combined with another arrhythmia
trigger, such as changes in the acid content of our blood that occur normally
as a by-product of exercise and sleep, particularly sleep apnea.

"For many years, we have studied sodium channels, the proteins in our
hearts that produce electrical signals. An earlier study of ours found that
temperature changes are a trigger for some seizure disorders. We imagined that
cardiac arrhythmias are like seizures and wondered whether they might share the
same triggers."

Ruben notes that with this new knowledge, people can examine their family
histories and, if sudden cardiac death is part of that family history, or if
they suffer from unexplained fainting, they can seek medical advice. Through a
combination of electrocardiograms, genetic screening, and lifestyle management,
some tragic deaths caused by cardiac arrhythmia may be prevented.







Story Source:

The above post is reprinted from materials provided
by Simon Fraser University. Note:
Materials may be edited for content and length.







Journal Reference:

1.   
Mena Abdelsayed, Colin H. Peters, Peter C. Ruben.Differential
thermosensitivity in mixed syndrome cardiac sodium channel mutants. The
Journal of Physiology, 2015; DOI: 10.1113/JP270139

http://www.sciencedaily.com/releases/2015/07/150716101526.htm

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