Tumor otak anak dapat diklasifikasikan noninvasif pada diagnosis--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

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Tumor otak anak dapat diklasifikasikan noninvasif pada diagnosis

Date:

August 7, 2015

Source:

Children's Hospital Los Angeles

Summary:.

Medulloblastoma , tumor otak ganas yang paling sering terjadi pada anak-anak , dapat diklasifikasikan ke dalam empat sub kelompok - masing-masing dengan profil risiko yang berbeda membutuhkan terapi - subkelompok tertentu. Penyidik ​​telah menemukan bahwa sub-kelompok dapat ditentukan non - invasif , menggunakan spektroskopi resonansi magnetik 

.............. " Dengan identifikasi subkelompok tumor pada saat diagnosis , kita akan dapat memulai terapi spesifik sebelumnya , " kata Shahab Asgharzadeh , MD , dari The Saban Research Institute di Rumah Sakit Anak Los Angeles , peneliti utama studi tersebut . Asgharzadeh juga seorang profesor Pediatrics dan Patologi di Keck School of Medicine dari University of Southern California ( USC ) .....more

Pediatric brain
tumors can be classified noninvasively at diagnosis

Medulloblastoma subgroups can be identified using imaging techniques,
allowing early intervention

Date:

August 7, 2015

Source:

Children's Hospital Los Angeles

Summary:

Medulloblastoma, the most commonly occurring malignant brain tumor in
children, can be classified into four subgroups -- each with a different risk
profile requiring subgroup-specific therapy. Investigators have now discovered
that these subgroups can be determined non-invasively, using magnetic resonance
spectroscopy.

.................

Medulloblastoma, the most commonly occurring malignant brain tumor in
children, can be classified into four subgroups--each with a different risk
profile requiring subgroup-specific therapy. Currently, subgroup determination
is done after surgical removal of the tumor. Investigators at Children's
Hospital Los Angeles have now discovered that these subgroups can be determined
non-invasively, using magnetic resonance spectroscopy (MRS). The paper has been
published online by the journal Neuro-Oncology.

"By identification of the tumor subgroup at the time of diagnosis, we
will be able to begin specific therapy earlier," said Shahab Asgharzadeh,
MD, of The Saban Research Institute of Children's Hospital Los Angeles,
principal investigator on the study. Asgharzadeh is also an associate professor
of Pediatrics and Pathology at the Keck School of Medicine of the University of
Southern California (USC).

Treatment for medulloblastoma includes surgery, chemotherapy and radiation,
with 5-year survival rates ranging from 30 to 90 percent depending upon risk
profile. A recent discovery identified four subtypes of medulloblastoma (SHH,
WNT, Group 3 and Group 4) with level of risk and clinical outcomes for each
subtype varying significantly. Currently, classification requires surgical
removal of the tumor followed by laboratory analysis of the tumor tissue. Given
the clinical importance of subgroup determinations, a fast, reliable and easily
accessible method could have a significant effect on the outcomes of children
with this disease.

"MR spectroscopy is widely available, noninvasive and provides
information on cellular metabolism, which is different in healthy and diseased
tissue," said Stefan Bluml, PhD, investigator at The Saban Research
Institute of CHLA and first author of the study. Bluml is also an associate
professor of Research, Radiology and Biomedical Engineering at the Viterbi
School of Engineering at USC.

Using frozen tumor tissue from 30 patients diagnosed with medulloblastoma,
investigators performed subgroup analysis using standard techniques. These
patients also had MRS performed at the time of diagnosis. With a screening
panel composed of five metabolites, investigators found that the spectra for
subgroups revealed distinct metabolic features, allowing them to differentiate
subgroups SHH, WNT from Groups 3 and 4.

Clinical trials are being developed to incorporate molecular subgroups into
risk and treatment stratifications. The ease of obtaining MRS at the time of
diagnosis should allow its incorporation into future clinical trials aimed at
validating this technique to improve diagnostic classification and, ultimately,
improve outcomes in children with medulloblastoma.







Story Source:

The above post is reprinted from materials provided byChildren's Hospital Los Angeles. Note:
Materials may be edited for content and length.







Journal Reference:

1.   
Stefan Blüml, Ashley S. Margol, Richard Sposto, Rebekah J. Kennedy, Nathan
J. Robison, Marzieh Vali, Long T. Hung, Sakunthala Muthugounder, Jonathan L.
Finlay, Anat Erdreich-Epstein, Floyd H. Gilles, Alexander R. Judkins, Mark D.
Krieger, Girish Dhall, Marvin D. Nelson, and Shahab Asgharzadeh. Molecular
subgroups of medulloblastoma identification using noninvasive magnetic
resonance spectroscopy. Neuro-Oncology, August 2015 DOI: 10.1093/neuonc/nov097

http://www.sciencedaily.com/releases/2015/08/150807144342.htm

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