Studi besar yang menuju selangkah lebih dekat untuk pengobatan asma berat--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

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Studi besar yang  menuju  selangkah lebih dekat untuk pengobatan  asma berat

Date:

September 9, 2015

Source:

European Lung Foundation

Summary:.

Temuan awal dari studi besar telah membantu mengidentifikasi karakteristik kunci dari asma yang parah , yang akan membantu dengan pengembangan pengobatan baru untuk pasien dengan kondisi tersebut .

........... tulisan  baru yang dipublikasikan secara online dalam European Respiratory Journal , adalah salah satu penilaian terbesar dari orang dewasa dengan asma berat sampai saat ini, melihat beberapa karakteristik termasuk gejala , kualitas hidup pasien dan darah dan pengukuran napas .................more

Major study moves a step closer to treatments for
severe asthma

Date:

September 9, 2015

Source:

European Lung Foundation

Summary:

Initial findings from a major study have
helped identify key characteristics of severe asthma, which will help with the development
of new treatments for patients with the condition.

.........

Initial findings from a major European
study have helped identify key characteristics of severe asthma, which will
help with the development of new treatments for patients with the condition.

The new paper, published online in
the European Respiratory Journal, is one of the largest assessments
of adults with severe asthma to date, looking at several characteristics
including symptoms, patients' quality of life and blood and airway measurements.

Over 30 million adults and children in
Europe suffer from asthma and it is estimated that of these, 4% (approximately
1.2 million people) have severe asthma. People with the disease experience
daily symptoms despite receiving high doses of medical treatment and are more
likely to be admitted to hospital and to require emergency healthcare. This
represents a significant burden on healthcare systems.

The U-BIOPRED (Unbiased BIOmarkers in
PREDiction of respiratory disease outcomes) project, funded by the Innovative
Medicines Initiative (IMI), was established in 2008 to better understand severe
asthma and identify new treatment targets.

This study involved four groups of adult
participants in 11 countries and followed them up for over a year; 311 non-smokers
with severe asthma, 110 smokers and ex-smokers with severe asthma, 88 patients
with milder asthma and 101 healthy volunteers. As part of the study, blood,
urine and sputum (mucus) samples were collected and lung function and other
anatomical tests were performed.

The results found that patients with
severe asthma had more symptoms and exacerbations compared to patients with
mild-moderate disease. Severe asthma patients also reported worse quality of
life and higher levels of anxiety and depression as well as more nasal polyps
(small growths in the nose), acid indigestion and poorer lung function.

A key finding is that although patients
with severe asthma take greater amounts of anti-inflammatory treatment,
including inhaled and oral steroids, they still had higher levels of
inflammation in their airways.

Lead author of the paper Dr Dominick
Shaw, from the University of Nottingham in the UK, said: "This study is
the first to describe severe asthma across such a large cohort. Our findings
are consistent with other recent descriptions of the condition and will enable
us now to identify distinct asthma phenotypes, or subgroups. Once we can break
this condition down into different groups, patients can be swiftly and
accurately diagnosed and individually treated by targeting the mechanisms that
are driving their own disease. Once we can identify these new treatments, we
can lessen the burden of this chronic and debilitating disease."

The U-BIOPRED study will continue to
publish findings from this cohort and a paediatric cohort in the coming months,
including papers due to be presented at the European Respiratory Society's
International Congress including descriptions of the first classification of
severe asthma types using different types of biological data.







Story Source:

The above post is reprinted from materials provided byEuropean Lung
Foundation. Note: Materials may be edited
for content and length.







Journal Reference:

1.   
Dominick E. Shaw et al. U-BIOPRED
severe asthma.European Respiratory Journal, September 2015 DOI:10.1183/13993003.00779-2015

http://www.sciencedaily.com/releases/2015/09/150909213414.htm

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