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Perbedaan utama dalam aktivitas otak pada orang dengan anoreksia nervosa diungkapkan dalam sebuah studi
Temuan yang membuka jalan baru untuk pengobatan masa depan
Date:
October 12, 2015
Source:
Zuckerman Mind Brain Behavior Institute
Summary:
Ketika orang-orang dengan anoreksia nervosa memutuskan apa yang harus dimakan , mereka terlibat dengan bagian dari otak yang berhubungan dengan perilaku kebiasaan . Temuan ini membuka jalan yang sama sekali baru untuk pengembangan pengobatan dan pemahaman tentang mekanisme penyakit , kata para peneliti .
........ Anorexia nervosa adalah penyakit serius dan membingungkan . Bahkan sebagai tanda-tanda klinis yang telah menjadi semakin diakui , tingkat kematian tetap salah satu yang tertinggi dari setiap gangguan kejiwaan . Sebuah fitur yang sangat stereotip dari penyakit ini adalah pemilihan terus-menerus dari rendah kalori , makanan rendah lemak , meskipun ada keinginan individu untuk perubahan . Mekanisme otak yang mendasari gangguan makan terus-menerus dan membatasi ini tidak jelas ....more
Key differences
in brain activity in people with anorexia nervosa revealed by study
Findings open up new avenues for future treatment
Date:
October 12, 2015
Source:
Zuckerman Mind Brain Behavior Institute
Summary:
When people with anorexia nervosa decide what to eat, they engage a part of
the brain associated with habitual behavior. These findings open up entirely
new avenues for treatment development and understanding of disease mechanisms,
say the researchers.
.....................................................
When people with anorexia nervosa decide what to eat, they engage a part of
the brain associated with habitual behavior. This finding by researchers at
Columbia University Medical Center, New York State Psychiatric Institute, the
Mortimer B. Zuckerman Mind Brain Behavior Institute, and New York University
was published inNature Neuroscience.
Anorexia nervosa is a serious and puzzling illness. Even as its clinical
signs have become increasingly recognized, the mortality rate remains among the
highest of any psychiatric disorder. A highly stereotyped feature of this
illness is the persistent selection of low-calorie, low-fat food, despite the
individual's desire for change. The brain mechanisms underlying this persistent
and restrictive eating disorder are unclear.
The researchers used functional magnetic resonance imaging--which tracks
activity in the brain in real time--to monitor 21 women with anorexia nervosa
and 21 healthy individuals while they made a series of choices about what food
to eat. As expected, individuals with anorexia nervosa consistently chose fewer
high-fat foods. The brain regions they used to make those choices were also
different: for individuals with anorexia nervosa, choices about what to eat
were associated with activation in the dorsal striatum, a brain region known to
be related to habitual control of actions. Furthermore, activation in
fronto-striatal brain circuits during the experiment predicted how many
calories they chose to consume in a meal the following day. These are the first
data linking abnormalities in brain activity with the salient behavioral
disturbance of anorexia nervosa, restrictive food choice.
These findings open up entirely new avenues for treatment development and
understanding of disease mechanisms. "We are already developing a new
psychotherapy intervention built on principles of habit reversal that helps
patients with anorexia nervosa change maladaptive behaviors," says Joanna
Steinglass, MD, one of the lead authors and associate professor of clinical
psychiatry at Columbia University Medical Center. "As we improve our
understanding of brain mechanisms, new medication targets may emerge as
well."
"This study may also help link anorexia nervosa to disorders like
substance abuse, gambling and other conditions that may involve choices related
to excessive activity in the dorsal striatum," added Daphna Shohamy, PhD,
author and associate professor of psychology and principal investigator at
Columbia University's Mortimer B. Zuckerman Mind Brain Behavior Institute.
"There is tremendous value in studying how the brain makes decisions in
both health and disease. Understanding how common brain circuits for
decision-making contribute to seemingly unrelated disorders will allow
researchers to focus on core disturbances and leverage treatment advances
across different disorders."
Story Source:
The above post is reprinted from materials provided byZuckerman Mind Brain Behavior Institute. Note: Materials may be edited for content and length.
Journal Reference:
1. Karin Foerde, Joanna E Steinglass, Daphna Shohamy, B Timothy Walsh. Neural
mechanisms supporting maladaptive food choices in anorexia nervosa. Nature
Neuroscience, 2015; DOI: 10.1038/nn.4136