Pedoman direvisi pada pengurangan risiko , pilihan pengobatan untuk penyakit tromboemboli pada kehamilan--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

10.10

thromboembolic disease

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Pedoman direvisi pada pengurangan risiko , pilihan pengobatan untuk penyakit tromboemboli pada kehamilan

Saran untuk mencegah dan mengobati tromboemboli vena ( VTE ) selama kehamilan , kelahiran dan setelah melahirkan diuraikan dalam dua pedoman baru  direvisi  . VTE jarang pada kehamilan atau dalam 6 minggu pertama postnatal dan risiko absolut sekitar 1 dari 1.000 kehamilan . Hal ini dapat terjadi pada setiap tahap kehamilan , tetapi saat risiko tertinggi adalah 6 minggu pertama setelah kelahiran , ketika risiko meningkat 20 kali lipat .....read more

Revised
guidelines on reducing risk, treatment options for thromboembolic disease in
pregnancy

Date:

April 16, 2015

Source:

Wiley

Summary:

Advice on preventing
and treating venous thromboembolism (VTE) during pregnancy, birth and following
delivery is outlined in two new revised guidelines. VTE is uncommon in
pregnancy or in the first 6 weeks postnatally and the absolute risk is around 1
in 1,000 pregnancies. It can occur at any stage in pregnancy, but the time of
the highest risk is the first 6 weeks following birth, when the risk increases
20-fold.

.........................

advice on preventing and
treating venous thromboembolism (VTE) during pregnancy, birth and following
delivery is outlined in two new revised guidelines published by the Royal
College of Obstetricians and Gynaecologists (RCOG) and launched at the RCOG
World Congress in Brisbane, Australia.

VTE refers to the formation of a clot within veins. This can occur anywhere
in the venous system, but the predominant sites are in the vessels of the leg
(giving rise to deep vein thrombosis (DVT)) and in the lungs (resulting in a
pulmonary embolism (PE)).

The Green-top Guidelines provide information, based on clinical evidence,
to assist clinicians with both the prevention and treatment of VTE in pregnant
women, a condition which remains the leading direct cause of maternal death in
the UK.

VTE is uncommon in pregnancy or in the first 6 weeks postnatally and the
absolute risk is around 1 in 1,000 pregnancies. It can occur at any stage in
pregnancy, but the time of the highest risk is the first 6 weeks following
birth, when the risk increases 20-fold.

Risk factors include previous VTE or thrombophilia (a tendency to form
blood clots), obesity, increased maternal age, immobility and long-distance
travel, admission to hospital during pregnancy and other comorbidities such as
heart disease, inflammatory bowel disease and pre-eclampsia.

Additional risk factors occurring during the first trimester of pregnancy
include hyperemesis gravidarum, ovarian hyperstimulation and IVF pregnancy.
Caesarean section is also a risk factor.

The guidelines emphasise that all women should undergo a thorough
assessment for VTE in early pregnancy or pre-pregnancy and again intrapartum or
immediately postpartum.

Any woman with risk factors should be considered for prophylactic
low-molecular-weight-heparin (LMWH), an injection administered to thin the
blood. The duration of treatment depends on the number of risk factors a woman
has. It may be offered both antenatally and after the baby is born.

In addition, women with previous VTE must be offered pre-pregnancy
counselling. A prospective management plan for VTE should also be made,
including appropriate treatment to be offered as early as possible and a
careful history documented.

The guidance on treating VTE focuses on the acute management of the
condition and highlights the signs and symptoms, including leg pain and
swelling, lower abdominal pain, shortness of breath, chest pain, coughing blood
and collapse.

Any woman presenting with signs and symptoms suggestive of VTE should be
tested for the condition immediately and offered treatment with
low-molecular-weight heparin (LMWH). All hospitals should have a protocol for
the diagnosis of suspected VTE, with the involvement of a multi-disciplinary
team of obstetricians, radiologists, physicians and haematologists.

Professor Catherine Nelson-Piercy, lead author of the guidance on
preventing thromboembolism says: "Venous thromboembolism is rare in
pregnancy and with prompt recognition can be treated effectively. This guidance
provides clinicians with accurate scientific-based guidelines on the risk
factors for VTE, as well as on how to prevent and treat the condition.

"It is vital that VTE is discussed with all women who are at risk and
the reasons for individual treatment recommendations must also be
explained."

Dr Andrew Thomson, lead author of the guideline on treating thromboembolism
and co-Chair of the RCOG Guidelines Committee says: "Previous editions of
these guidelines have been credited with a reduction in the number of women
dying from thromboembolism during their pregnancy or in the postnatal period in
the UK. Nonetheless, thromboembolism remains an important cause of maternal
morbidity and mortality in our country.

"These updated guidelines provide new evidence about risk factors for
thrombosis in pregnancy and strategies that should be employed to reduce the
chances of a thrombosis occurring. Furthermore, the guidelines provide updated
information on the way women with a suspected thrombosis should be investigated
and treated."







Story Source:

The above story is based on materials provided by Wiley. Note: Materials may be edited
for content and length.

http://www.sciencedaily.com/releases/2015/04/150416132334.htm

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Penyakit Ginjal Kronis mungkin Meningkatkan Risiko Tertentu Selama Kehamilan--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

06.52

pregnancy

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08995557626
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www.facebook.com/groups/komunitassatwaeksotik/
 KSE = KOMUNITAS SATWA EKSOTIK

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GABUNG......... ( menerima keanggotaan seluruh kota dan daerah di Indonesia )
HUBUNGI   :  089617123865

.........................

Penyakit Ginjal Kronis mungkin  Meningkatkan Risiko Tertentu Selama Kehamilan

Di antara perempuan hamil ,hasil  risiko kehamilan - seperti yang merugikan .....seperti kelahiran prematur atau kebutuhan untuk perawatan intensif neonatal - meningkat di tahap penyakit ginjal kronis , sebuah penelitian menyimpulkan ...... Risiko kematian janin atau malformasi intrauterin tidak lebih tinggi pada wanita dengan penyakit ginjal kronis .....read more

Chronic Kidney
Disease May Increase Certain Risks During Pregnancy

Date:

March 12, 2015

Source:

American Society of
Nephrology (ASN)

Summary:

Among pregnant women,
the risk for adverse pregnancy outcomes—such as preterm delivery or the need
for neonatal intensive care—increased across stages of chronic kidney disease,
a study concludes. The risks of intrauterine death or fetal malformations were
not higher in women with chronic kidney disease.

.......................

even mild kidney disease
during pregnancy may increase certain risks in the mother and baby, according
to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). The findings may be helpful
for guiding prenatal counseling and for monitoring women during pregnancy.

Chronic kidney disease (CKD) is on the rise, and studies suggest that even
early stages of the disease can affect pregnancy outcomes. An Italian research
team led by Giorgina Barbara Piccoli, MD, Rossella Attini, MD, PhD (University
of Torino), and Gianfranca Cabiddu, MD (Azienda Ospedaliera Brotzu) recently
conducted a study -- called the TOCOS (TOrino-Cagliari Observational Study) --
that compared pregnancy outcomes of 504 pregnancies in women with CKD with
outcomes of 836 low-risk pregnancies in women without CKD.

The researchers found that the risk for adverse pregnancy outcomes -- such
as preterm delivery, the need for neonatal intensive care, or the development
of hypertension in the mother -- increased across CKD stages. However, the risk
was not merely linked to reduced kidney function because stage 1 CKD patients
and healthy controls differed significantly, despite the fact that patients
with stage 1 CKD are asymptomatic and have kidney function within the normal
range. The team also found that the risks of intrauterine death or fetal
malformations did not differ between patients and healthy controls.

"The findings indicate that any kidney disease -- even the least
severe, such as a kidney scar form a previous episode of kidney infection, with
normal kidney function -- has to be regarded as relevant in pregnancy, and all
patients should undergo a particularly careful follow-up," said Dr.
Piccoli. "Conversely, we also found that a good outcome was possible in
patients with advanced CKD, who are often discouraged to pursue
pregnancy," she added.

The investigators hope that the new findings may help establish dedicated
programs for the early diagnosis and follow up of pregnancy in CKD. "We
are presently working on a model for 'grading' the risks that will provide
patients and physicians with information when making choices about undergoing
and monitoring pregnancies," said Dr. Piccoli.







Story Source:

The above story is based on materials provided by American Society of Nephrology
(ASN). Note: Materials may be edited for content and length.







Journal Reference:

1.    Giorgina Barbara Piccoli, Gianfranca
Cabiddu, Rossella Attini, Federica Neve Vigotti, Stefania Maxia, Nicola Lepori,
Milena Tuveri, Marco Massidda, Cecilia Marchi, Silvia Mura, Alessandra Coscia, Marilisa
Biolcati, Pietro Gaglioti, Michele Nichelatti, Luciana Pibiri, Giuseppe Chessa,
Antonello Pani, and Tullia Todros.Risk of Adverse Pregnancy Outcomes in
Women with CKD. Journal of the American Society of Nephrology,
March 2015 DOI: 10.1681/ASN.2014050459

http://www.sciencedaily.com/releases/2015/03/150312173530.htm

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penemuan baru siklus tidur menjelaskan mengapa diet lemak selama kehamilan membuat anak-anak obesitas--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

04.01

sleep cycle

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 KSE = KOMUNITAS SATWA EKSOTIK

MENGATASI KENDALA MINAT DAN JARAK

KAMI ADA DI TIAP KOTA DI INDONESIA 

DETAIL TENTANG KSE-----KLIK : www.komunitassatwaeksotik-pendaftaran.blogspot.com 

GABUNG......... ( menerima keanggotaan seluruh kota dan daerah di Indonesia )

HUBUNGI   :  089617123865

.........................

 penemuan baru  siklus tidur menjelaskan mengapa diet lemak selama kehamilan membuat anak-anak obesitas

Hubungan antara tidur dan obesitas diambil sebagai penelitian baru yang  menunjukkan bahwa apa yang ibu Anda makan saat hamil dapat membuat Anda gemuk atau kelebihan berat badan dengan mengubah fungsi gen ( perubahan epigenetik ) yang mengatur ritme sirkadian ....read more

New sleep cycle discovery explains why fatty diets during pregnancy make kids obese

Date:

November 23, 2010

Source:

Federation of American Societies for Experimental Biology

Summary:

The link between sleeping and obesity is drawn tighter as a new research shows that what your mother ate when she was pregnant may make you obese or overweight by altering the function of genes (epigenetic changes) that regulate circadian rhythm.

..............

the link between sleeping and obesity is drawn tighter as a new research published online in the FASEB Journal study shows that what your mother ate when she was pregnant may make you obese or overweight by altering the function of genes (epigenetic changes) that regulate circadian rhythm. In the report, pregnant primate females consuming a high-fat diet altered the function of fetal genes that regulate circadian rhythm (including appetite and food intake) during development. The offspring also had non-alcoholic fatty liver disease.

"It is our hope that our studies will continue to guide research aimed at understanding the pivotal role that maternal health plays in guiding the health of the next generation," said Kjersti Aagaard-Tillery, M.D., Ph.D., a researcher involved in the work from the Department of Obstetrics and Gynecology at Baylor College of Medicine in Houston. "We are enthusiastic that our research will give hope that even small changes, such as improving one's diet in pregnancy and during breastfeeding, will translate into a lower chance for obesity in our next generation."

To make this discovery, Aagaard-Tillery and colleagues studied three groups of Japanese macaque primates. One group was fed a 12 percent fat diet (the control group). The second group was fed a 35 percent fat or high-fat diet and the third group was fed the high-fat diet for up to five years and then switched back to the control diet. Each group maintained their specific diet prior to conception and throughout pregnancy. Offspring from the high-fat group developed non-alcoholic fatty liver disease; experienced changes in histones (the core set of proteins which DNA wrap around), and had altered metabolic profiles and circadian rhythms. Results also showed that the genes in the fetal liver, which are responsible for orchestrating circadian rhythms with appetite and food intake, are altered in offspring from the mothers on the high-fat diet. Specifically, one of these genes, called Npas2, is a key regulator of the circadian system and is itself regulated by changes in the fetal histone code. Scientists found that improving the diet, either for the pregnant or breastfeeding mother, or for the infant after birth, helps to partially restore the circadian machinery back to normal, possibly lessening the risk of childhood diseases related to obesity.

"We've recently published a number of studies in the FASEB Journal showing that what a mother eats affects the weight of her children for their entire lives," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal. "Now, we know why, and what a wake-up call for pregnant women! The mother's diet during pregnancy affects their children's sleep machinery via genetic machinery that controls the sleep cycle. Children are literally forced to sleep in the proverbial bed their mothers have made."

---

Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.

---

Journal Reference:

1.    M. Suter, P. Bocock, L. Showalter, M. Hu, C. Shope, R. McKnight, K. Grove, R. Lane, K. Aagaard-Tillery. Epigenomics: maternal high-fat diet exposure in utero disrupts peripheral circadian gene expression in nonhuman primates.The FASEB Journal, 2010; DOI: 10.1096/fj.10-172080

http://www.sciencedaily.com/releases/2010/11/101122111506.htm

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Penelitian baru menyarankan pengobatan tekanan darah tinggi selama kehamilan--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

10.44

pregnancy

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 KSE = KOMUNITAS SATWA EKSOTIK

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KAMI ADA DI TIAP KOTA DI INDONESIA 

DETAIL TENTANG KSE-----KLIK : www.komunitassatwaeksotik-pendaftaran.blogspot.com 

GABUNG......... ( menerima keanggotaan seluruh kota dan daerah di Indonesia )

HUBUNGI   :  089617123865

.........................

Penelitian baru menyarankan pengobatan  tekanan darah tinggi selama kehamilan

Mengobati tekanan darah tinggi wanita selama kehamilan adalah lebih aman baginya dan aman untuk bayi , sebuah studi baru menunjukkan ....Penelitian ini membahas keyakinan kuno bahwa mengurangi tekanan darah tinggi selama kehamilan dapat mengakibatkan pertumbuhan berkurang dalam kandungan dan kesehatan buruk saat lahir .....read more

New research
recommends treating elevated blood pressure during pregnancy

Date:

January 29, 2015

Source:

Child & Family
Research Institute

Summary:

Treating a woman's
elevated blood pressure during pregnancy is safer for her and safe for the
baby, a new study shows. The study addresses an age-old belief that reducing
elevated blood pressure during pregnancy might lead to reduced growth in the
womb and worse health at birth.

...................

throughout her career in
Canada and the UK, Dr. Laura Magee has taken a restrained approach to use of
blood pressure-lowering medication in her pregnant patients, fearing that
lowering pressure could reduce the flow of blood and vital nutrients to their
babies.

But Magee, a researcher at the Child & Family Research Institute (CFRI)
and the University of British Columbia (UBC), and a physician at BC Women's
Hospital and Health Centre, an agency of the Provincial Health Services
Authority (PHSA), has up-ended her own beliefs with an international study
being published today in the New England Journal of Medicine.

The 15-country study shows that treating a woman's elevated blood pressure
during pregnancy is safer for her, and safe for her baby. As a result of these
findings, Magee and her collaborators recommend normalizing blood pressure in
pregnant women.

"Before this study, I was a 'less tight' controller," Magee says.
"I was hoping that this approach would be better for the baby, without
increasing risks for the mother. However, I was wrong. 'Less tight' control,
which means allowing blood pressure to be mildly to moderately elevated in
pregnancy, is not better for the baby. It's actually harmful to the mother, who
will more often experience levels of blood pressure that increase the risk of
stroke. As a responsible maternity care provider, I can no longer justify a
'less tight' approach to blood pressure control."

The study, which tracked the health of 987 women and their newborns at 94
sites around the world, addresses an age-old belief that reducing elevated
blood pressure during pregnancy might lead to reduced growth in the womb and
worse health at birth.

But normalizing a pregnant women's elevated blood pressure did not result
in poorer outcomes for babies before or after birth. At the same time, allowing
the mother's blood pressure to be mildly to moderately elevated in pregnancy
led to more episodes of dangerously elevated blood pressure that increase the
risk of stroke and death for the mother during pregnancy.

About the study:

·        
The CHIPS Trial (Control of Hypertension in Pregnancy Study) was designed
to study the impact of either 'less tight' or 'tight' control of high blood
pressure during pregnancy on outcomes for the baby and for the mother.

·        
987 women participated between 2009 and 2012 at 94 study sites in 15
countries.

·        
Women participating were between 14 and 33 weeks pregnant. They were
randomly assigned to one of two groups. A group of 497 women had 'less tight'
control with a target diastolic blood pressure of 100 mmHg, while the second
group of 490 women had 'tight' control with a target diastolic blood pressure
of 85 mmHg.

·        
Most of the women in both groups received blood pressure medication at some
point in the trial (77 per cent in the 'less tight' group and 94 per cent in
the 'tight' control group).

·        
The researchers found that the number of babies who died or were admitted
for prolonged newborn intensive care was similar between the two blood pressure
control groups. Fetal growth was also similar.

·        
The study was funded by the Canadian Institutes of Health Research.

Quick facts:

·        
Up to 10 per cent of pregnant women worldwide suffer from hypertension.

·        
All women with hypertension in pregnancy are at increased risk of poor
outcomes for themselves and for their babies. These risks are further increased
when women have hypertension before 34 weeks of pregnancy.

·        
Dr. Magee and study co-author Dr. Peter von Dadelszen received the
prestigious Chesley Award at the 2014 World Congress of the International
Society for Study of Hypertension in Pregnancy.

Quotes:

Dr. Laura Magee, CFRI Senior Clinical Scientist; Physician, BC Women's
Hospital & Health Centre, a PHSA agency; UBC Clinical Professor, General
Internal Medicine: "Our trial showed that you should treat a mother's high
blood pressure in pregnancy. This reduces her risk without increasing the risks
for her baby."

Carl Roy, PHSA President & CEO: "This important finding again
demonstrates why research is so vital to the mandate of the Provincial Health
Services Authority. Our goal is that together with our partners in government,
academia and the scientific community, we can translate findings like these
into even better health care for patients."

Dr. Mark Brown, President, International Society for the Study of Hypertension
in Pregnancy and Professor, University of New South Wales: "For almost 50
years, there has been major controversy over whether it is safe or dangerous to
use blood pressure lowering medications during pregnancy. Following this well
conducted CHIPS study, which is one of a very small number of landmark studies
in this field, we now have an answer: A lower level of blood pressure lessens
the risk of stroke for hypertensive pregnant women without causing any new risk
for baby. This will have a direct impact on the health of pregnant women
worldwide."

Dr. Sandra Lowe, President, International Society of Obstetric Medicine;
Professor, University of New South Wales; Obstetric Physician, Royal Hospital
for Women; lead author of the 2014 Society of Obstetric Medicine of Australia
and New Zealand Guidelines for Management of Hypertensive Disorders of
Pregnancy: "This study has addressed the long standing issue of what blood
pressure targets we should be aiming for in pregnancy to keep both mother and baby
safe. This trial supports that aiming for more "normal" blood
pressure reduced the number of episodes of severe and dangerous maternal
hypertension, with no increase in the rate of complications for their
babies."







Story Source:

The above story is based on materials provided by Child
& Family Research Institute. Note: Materials may be edited for content and length.

http://www.sciencedaily.com/releases/2015/01/150129104324.htm

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