Bagaimana kadal meregenerasi ekor mereka : Para peneliti menemukan ' resep ' genetik--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

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Bagaimana kadal meregenerasi ekor mereka : Para peneliti menemukan  ' resep ' genetik

Dengan memahami rahasia bagaimana kadal regenerasi ekor mereka , para peneliti mungkin dapat mengembangkan cara-cara untuk merangsang regenerasi anggota badan pada manusia . Sekarang , salah satu langkah lebih dekat dari tim peneliti  untuk memecahkan misteri itu. Para ilmuwan telah menemukan  " resep " genetic untuk  regenerasi ekor kadal  , yang menggunakan bahan-bahan genetik ...more

How lizards regenerate their tails:
Researchers discover genetic 'recipe'

Date:

August 20, 2014

Source:

Arizona State University College of Liberal Arts and Sciences

Summary:

By understanding the secret of how lizards regenerate their tails,
researchers may be able to develop ways to stimulate the regeneration of limbs
in humans. Now, a team of researchers is one step closer to solving that
mystery. The scientists have discovered the genetic “recipe” for lizard tail
regeneration, which may come down to using genetic ingredients in just the
right mixture and amounts.

........................

By understanding the secret of how lizards regenerate their tails,
researchers may be able to develop ways to stimulate the regeneration of limbs
in humans. Now, a team of researchers from Arizona State University is one step
closer to solving that mystery. The scientists have discovered the genetic
"recipe" for lizard tail regeneration, which may come down to using
genetic ingredients in just the right mixture and amounts.

An interdisciplinary team of scientists used next-generation molecular and
computer analysis tools to examine the genes turned on in tail regeneration.
The team studied the regenerating tail of the green anole lizard (Anolis
carolinensis), which when caught by a predator, can lose its tail and then
grow it back.

The findings are published today in the journal PLOS ONE.

"Lizards basically share the same toolbox of genes as humans,"
said lead author Kenro Kusumi, professor in ASU's School of Life Sciences and
associate dean in the College of Liberal Arts and Sciences. "Lizards are
the most closely-related animals to humans that can regenerate entire
appendages. We discovered that they turn on at least 326 genes in specific
regions of the regenerating tail, including genes involved in embryonic
development, response to hormonal signals and wound healing."

Other animals, such as salamanders, frog tadpoles and fish, can also
regenerate their tails, with growth mostly at the tip. During tail regeneration,
they all turn on genes in what is called the 'Wnt pathway' -- a process that is
required to control stem cells in many organs such as the brain, hair follicles
and blood vessels. However, lizards have a unique pattern of tissue growth that
is distributed throughout the tail.

"Regeneration is not an instant process," said Elizabeth
Hutchins, a graduate student in ASU's molecular and cellular biology program
and co-author of the paper. "In fact, it takes lizards more than 60 days
to regenerate a functional tail. Lizards form a complex regenerating structure
with cells growing into tissues at a number of sites along the tail."

"We have identified one type of cell that is important for tissue
regeneration," said Jeanne Wilson-Rawls, co-author and associate professor
with ASU's School of Life Sciences. "Just like in mice and humans, lizards
have satellite cells that can grow and develop into skeletal muscle and other
tissues."

"Using next-generation technologies to sequence all the genes
expressed during regeneration, we have unlocked the mystery of what genes are
needed to regrow the lizard tail," said Kusumi. "By following the
genetic recipe for regeneration that is found in lizards, and then harnessing
those same genes in human cells, it may be possible to regrow new cartilage,
muscle or even spinal cord in the future."

The researchers hope their findings will help lead to discoveries of new
therapeutic approaches to spinal cord injuries, repairing birth defects, and
treating diseases such as arthritis.

The research team included Kusumi, Hutchins, Wilson-Rawls, Alan Rawls, and
Dale DeNardo from ASU School of Life Sciences, Rebecca Fisher from ASU School
of Life Sciences and the University of Arizona College of Medicine Phoenix,
Matthew Huentelman from the Translational Genomic Research Institute, and Juli
Wade from Michigan State University. This research was funded by grants from
the National Institutes of Health and Arizona Biomedical Research Commission.







Story Source:

The above story is based on materials provided
by Arizona State University College of Liberal Arts and Sciences.Note: Materials
may be edited for content and length.







Journal Reference:

1.   
Elizabeth D. Hutchins, Glenn J. Markov, Walter L. Eckalbar, Rajani M.
George, Jesse M. King, Minami A. Tokuyama, Lauren A. Geiger, Nataliya Emmert,
Michael J. Ammar, April N. Allen, Ashley L. Siniard, Jason J. Corneveaux,
Rebecca E. Fisher, Juli Wade, Dale F. DeNardo, J. Alan Rawls, Matthew J.
Huentelman, Jeanne Wilson-Rawls, Kenro Kusumi. Transcriptomic Analysis
of Tail Regeneration in the Lizard Anolis carolinensis Reveals Activation of
Conserved Vertebrate Developmental and Repair Mechanisms. PLoS ONE,
2014; 9 (8): e105004 DOI:10.1371/journal.pone.0105004

http://www.sciencedaily.com/releases/2014/08/140820164317.htm

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