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Bakteri bekerja sama untuk memperbaiki saudaranya yang rusak
Date:
May 21, 2015
Source:
University of Wyoming
Summary:
Penelitian baru menunjukkan, Sebuah jenis bakteri tanah tertentu dapat menggunakan perilaku sosial mereka pada pertukaran membran luar untuk memperbaiki sel-sel yang rusak dan meningkatkan kebugaran populasi bakteri secara keseluruhan . Ini adalah bukti pertama bahwa bakteri dapat menggunakan sel – konten berbagi untuk memperbaiki saudaranya yang rusak , ......read more
Bacteria cooperate to repair damaged
siblings
Date:
May 21, 2015
Source:
University of Wyoming
Summary:
A certain type of soil bacteria can use their social behavior of outer
membrane exchange to repair damaged cells and improve the fitness of the bacteria
population as a whole, new research demonstrates. This is the first evidence
that a bacterium can use cell-content sharing to repair damaged siblings, the
authors say.
.........................
A University of Wyoming faculty member led a research team that discovered
a certain type of soil bacteria can use their social behavior of outer membrane
exchange (OME) to repair damaged cells and improve the fitness of the bacteria
population as a whole.
Daniel Wall, a UW associate professor in the Department of Molecular
Biology, and others were able to show that damaged sustained by the outer
membrane (OM) of a myxobacteria cell population was repaired by a healthy
population using the process of OME. The research revealed that these social
organisms benefit from group behavior that endows favorable fitness
consequences among kin cells.
Wall says, to the research group's knowledge, this is the first evidence
that a bacterium can use cell-content sharing to repair damaged siblings.
"It is analogous to how a wound in your body can be healed," Wall
says. "When your body is wounded, your cells can coordinate their
functions to heal the damaged tissue."
Wall was the senior and corresponding author on a paper, titled "Cell
Rejuvenation and Social Behaviors Promoted by LPS Exchange in
Myxobacteria" that was published in the May 18 online issue of the Proceedings
of the National Academy of Sciences (PNAS).
Chris Vassallo, a UW doctoral student in molecular biology and originally
from Cheyenne, was the paper's lead author and conducted most of the lab
experiments.
"During nutrient depletion, myxobacteria cooperate to build a
macroscopic structure called a fruiting body," Vassallo says. "The
structure resembles a tree or mushroom in appearance."
A fruiting body is essentially a multicellular organism that produces
dormant spores that are resistant to environmental stresses.
These myxobacterial cells, in their native environments, must cope with
factors that compromise the integrity of the cell, Wall says. Rather than
looking out only for themselves like other bacterial species, the individual
myxobacteria cells band together as a social group to assist their kin that
become damaged.
"Myxobacteria are unusual for bacteria in that they have a true
multicellular life," Wall says. "Researchers are interested in how
the evolutionary transition occurred toward multi-cellularity; that is, how
cooperation develops and single cells are not just interested in themselves.
The Darwinian view is that each individual is out for themselves; 'survival of
the fittest.'"
"When environmental cells come together, they compete with each
other," Wall continues. "With OME, we think it allows myxobacteria
cells to transition from a heterogeneous single cellular life to a more
harmonious multicellular life."
While the practical application of the science is to better understand how
single cells can evolve to multicellular cells to be cooperative, Vassallo says
the research could possibly have future real-world implications for treating
infections in humans.
"The most direct applicability could be for antibiotic
resistance," Wall says. "Within the paper, Chris did an experiment
where one strain of myxobacteria conferred antibiotic resistance to another
strain. This works by the cells transferring their OM armor.
"The human skin protects the body and internal cells from
environmental stresses. By analogy, bacteria protect themselves with their OM,
and they are known to change their armor in response to stress. When they
chemically change their armor, they can also change their antibiotic resistance
profile."
Story Source:
The above story is based on materials provided
by University of Wyoming. Note:
Materials may be edited for content and length.
Journal Reference:
1.
Christopher Vassallo, Darshankumar T. Pathak, Pengbo Cao, David M.
Zuckerman, Egbert Hoiczyk, Daniel Wall. Cell rejuvenation and social
behaviors promoted by LPS exchange in myxobacteria. Proceedings of
the National Academy of Sciences, 2015; 201503553 DOI:10.1073/pnas.1503553112