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Obat Anti -stroke  pengobatan yang efektif untuk infeksi telinga tengah 

Date:

May 21, 2015

Source:

Georgia State University

Summary:

obat anti -stroke adalah pengobatan yang efektif untuk infeksi telinga tengah , menunjukkan kemampuan untuk menekan lendir berlebih , meningkatkan  bakteri clearance  dan mengurangi gangguan pendengaran ,..........read more

Anti-stroke drug effective treatment for
middle-ear infections, researchers say

Date:

May 21, 2015

Source:

Georgia State University

Summary:

An existing anti-stroke drug is an effective treatment for middle-ear
infections, showing the ability to suppress mucus overproduction, improve
bacterial clearance and reduce hearing loss, according to researchers.

..........................

An existing anti-stroke drug is an effective treatment for middle-ear
infections, showing the ability to suppress mucus overproduction, improve
bacterial clearance and reduce hearing loss, according to researchers at
Georgia State University and the University of Rochester.

The findings, published May 13 in the Journal of Immunology,
could result in a novel, non-antibiotic treatment for otitis media, or
middle-ear infection, possibly through topical drug delivery. Vinpocetine, the
drug involved in the study, has long been used to treat neurological disorders
such as stroke.

The study found topical administration of Vinpocetine suppressed
inflammation and the overproduction of mucus induced by Streptococcus pneumonia
bacteria, improved hearing loss in the middle ear and significantly improved
bacterial clearance in animal studies.

"Our encouraging preliminary data suggest that the repurposed drug
Vinpocetine may play a critical role in inhibiting inflammation and enhancing
antimicrobial defenses in otitis media," said Dr. Jian-Dong Li, director
of the Institute for Biomedical Sciences at Georgia State and a Georgia Research
Alliance Eminent Scholar in Inflammation and Immunity. "Our proposed
studies may lead to developing novel, non-antibiotic therapeutic strategies to
control immunopathology, reduce mucus overproduction, improve hearing loss and
enhance host defense for otitis media."

Otitis media is the most common childhood bacterial infection and the
leading cause of conductive hearing loss. Streptococcus pneumonia is one of the
most common bacterial pathogens causing middle-ear infection.

In the United States, there are 24.5 million visits to physicians' offices
each year because of otitis media and more than $5 billion is spent annually
for the care of this disease, according to studies in Pediatric Annals and
Otolaryngology -- Head and Neck Surgery.

Children with frequent middle-ear infections may suffer from speech and
language disabilities because otitis media causes hearing loss during a crucial
period for speech and language development.

There is an urgent need for novel, non-antibiotic agents to suppress
overactive inflammation without significant side effects. There are no
effective non-antibiotic agents for otitis media because of poor understanding
of the Streptococcus pneumonia pathogenesis. Inappropriate antibiotic use has
led to increased antibiotic resistance. Vaccines against Streptococcus
pneumonia have a limited impact on otitis media, Li said.

Mucin, the major component of mucus, plays an important role in the
clearance of bacterial pathogens, but uncontrolled, excessive mucus production
can lead to conductive hearing loss and decreased bacterial clearance. There is
also a lack of effective therapeutic agents for controlling mucus
overproduction in otitis media.

This study's findings could also have a significant impact as a new
treatment option in countries where surgery is not readily available, Li said.

Drug repositioning has several advantages over traditional drug discovery,
such as reduced safety risk, side effects, time and costs. There have been no
reports of significant adverse effects and toxicity at therapeutic doses of
Vinpocetine in adults and children. As a result, Vinpocetine is attractive to
scientists and clinicians seeking novel therapeutic applications.

Vinpocetine, an alkaloid extracted from the periwinkle plant, was
originally discovered and marketed in 1978 under the trade name Cavinton. It is
used as an anti-stoke drug in most countries and a dietary supplement
worldwide.







Story Source:

The above story is based on materials provided
by Georgia State University. Note:
Materials may be edited for content and length.







Journal Reference:

1.   
J.-Y. Lee, K. Komatsu, B.-C. Lee, M. Miyata, A. O'Neill Bohn, H. Xu, C.
Yan, J.-D. Li. Vinpocetine Inhibits Streptococcus pneumoniae-Induced
Upregulation of Mucin MUC5AC Expression via Induction of MKP-1 Phosphatase in
the Pathogenesis of Otitis Media. The Journal of Immunology,
2015; DOI:10.4049/jimmunol.1401489

http://www.sciencedaily.com/releases/2015/05/150521133520.htm

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