Obat dari air liur kadal gila monster mengurangi hasrat untuk cokelat dan makanan--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

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Obat dari air liur kadal gila monster  mengurangi hasrat untuk cokelat dan makanan

Obat yang terbuat dari air liur Gila monster  efektif dalam mengurangi keinginan untuk makanan . Para peneliti telah menguji obat pada tikus , yang setelah pengobatan menghentikan  keinginan mereka untuk makanan dan cokelat ......more

Drugs from gila monster lizard saliva
reduces cravings for chocolate and ordinary food

Date:

May 15, 2012

Source:

University of Gothenburg

Summary:

A drug made from the saliva of the Gila monster lizard is effective in
reducing the craving for food. Researchers have tested the drug on rats, who
after treatment ceased their cravings for both food and chocolate.

.......................

A drug made from the saliva of the Gila monster lizard is effective in
reducing the craving for food. Researchers at the Sahlgrenska Academy,
University of Gothenburg, have tested the drug on rats, who after treatment
ceased their cravings for ordinary food and also chocolate.

An increasing number of patients suffering from type 2 diabetes are offered
a pharmaceutical preparation called Exenatide, which helps them to control
their blood sugar. The drug is a synthetic version of a natural substance
called exendin-4, which is obtained from a rather unusual source -- the saliva
of the Gila monster lizard (Heloderma suspectum), North America's
largest lizard.

Unexpected effect

Researchers at the Sahlgrenska Academy at the University of Gothenburg,
have now found an entirely new and unexpected effect of the lizard substance.

Reduces cravings for food

In a study with rats published in the Journal of Neuroscience,Assistant
Professor Karolina Skibicka and her colleagues show that exendin-4 effectively
reduces the cravings for food.

"This is both unknown and quite unexpected effect," comments an
enthusiastic Karolina Skibicka: "Our decision to eat is linked to the same
mechanisms in the brain which control addictive behaviours. We have shown that
exendin-4 affects the reward and motivation regions of the brain."

Significant findings

The implications of the findings are significant" states Suzanne
Dickson, Professor of Physiology at the Sahlgrenska Academy: "Most dieting
fails because we are obsessed with the desire to eat, especially tempting foods
like sweets. As exendin-4 suppresses the cravings for food, it can help obese
people to take control of their weight," suggests Professor Dickson.

Treatment for eating disorders

Research on exendin-4 also gives hope for new ways to treat diseases
related to eating disorders, for example, compulsive overeating.

Another hypothesis for the Gothenburg researchers' continuing studies is
that exendin-4 may be used to reduce the craving for alcohol.

"It is the same brain regions which are involved in food cravings and
alcohol cravings, so it would be very interesting to test whether exendin-4 also
reduces the cravings for alcohol," suggests Assistant Professor Skibicka.







Story Source:

The above story is based on materials provided
by University of Gothenburg. Note:
Materials may be edited for content and length.







Journal Reference:

1.   
Suzanne L. Dickson, Rozita H. Shirazi, Caroline Hansson, Filip Bergquist,
Hans Nissbrandt, and Karolina P. Skibicka.The Glucagon-Like Peptide 1
(GLP-1) Analogue, Exendin-4 Decreases the Rewarding Value of Food: A New Role
for the Mesolimbic GLP-1 Receptors. Journal of Neuroscience,
April 4, 2012 DOI:10.1523/%u200BJNEUROSCI.6326-11.2012

http://www.sciencedaily.com/releases/2012/05/120515165405.htm

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