Gut worms melindungi otak bayi dari peradangan--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

SILAHKAN MENGGUNAKAN " MESIN TRANSLATE "..GOOGLE TRANSLATE
DISAMPING KANAN INI.............

PLEASE USE ........ "TRANSLATE MACHINE" .. GOOGLE TRANSLATE BESIDE RIGHT THIS

.................


T-REC -TUGUMUDA REPTILES COMMUNITY-INDONESIA


More info :
www.trecsemarang2011.blogspot.com
minat gabung : ( menerima keanggotaan seluruh kota dan daerah di Indonesia )
08995557626
..................................
KSE – KOMUNITAS SATWA EKSOTIK – EXOTIC PETS COMMUNITY-- INDONESIA
Visit Our Community and Joint W/ Us....Welcome All Over The World
www.facebook.com/groups/komunitassatwaeksotik/
 KSE = KOMUNITAS SATWA EKSOTIK

MENGATASI KENDALA MINAT DAN JARAK

KAMI ADA DI TIAP KOTA DI INDONESIA
DETAIL TENTANG KSE-----KLIK : www.komunitassatwaeksotik-pendaftaran.blogspot.com

GABUNG......... ( menerima keanggotaan seluruh kota dan daerah di Indonesia )
HUBUNGI   :  089617123865-08995557626

.........................

Gut worms  melindungi otak bayi dari peradangan

Date:

July 20, 2015

Source:

Duke University

Summary:

Gut worms can protect babies' brains from inflammation and long-term learning and memory problems caused by newborn infections, a new study on rats has shown. Expectant mother rats with tapeworms even passed the protective benefits on to their worm-free pups, the researchers found. The findings could point to new ways to prevent or treat the chronic brain inflammation linked to cognitive disorders like Alzheimer's disease, autism and depression.

Sebuah studi pada tikus menunjukkan, Gut worm  dapat melindungi otak bayi dari peradangan dan pembelajaran jangka panjang dan masalah memori  yang disebabkan oleh infeksi bayi baru lahir  . para peneliti menemukan , Tikus betina  hamil dengan tape worm bahkan lulus manfaat perlindungan pada worm-free pups  . Temuan ini bisa menunjukkan cara baru untuk mencegah atau mengobati radang otak kronis terkait dengan gangguan kognitif seperti penyakit Alzheimer , autisme dan depresi 

................. Baby rats with tapeworms avoided the brain inflammation that plagued worm-free rats after exposure to immune triggers in adulthood.

What's more, the benefits began early, while still in the womb. Expectant mother rats with tapeworms passed similar protection on to their worm-free pups, the researchers found.

The findings could point to new ways to treat or prevent the chronic brain inflammation linked to cognitive disorders like Alzheimer's disease, autism and depression.

The study appears online in the journal Brain, Behavior, and Immunity.

................. bayi Tikus  dengan tapeworm  menghindari radang otak yang dialami plagued worm-free rats  setelah terpapar pemicu kekebalan tubuh di masa dewasa .

Terlebih lagi , manfaat mulai awal , saat masih dalam kandungan . Tikus betina  hamil dengan tapeworm  melewati perlindungan yang sama kepada worm-free pups  , temuan para peneliti  .

Temuan bisa menunjukkan cara-cara baru untuk mengobati atau mencegah radang otak kronis terkait dengan gangguan kognitif seperti penyakit Alzheimer , autisme dan depresi .

Studi ini muncul secara online dalam jurnal Brain , Behavior , and Immunity ......more

Gut worms
protect babies' brains from inflammation

Date:

July 20, 2015

Source:

Duke University

Summary:

Gut worms can protect babies' brains from inflammation and long-term
learning and memory problems caused by newborn infections, a new study on rats
has shown. Expectant mother rats with tapeworms even passed the protective
benefits on to their worm-free pups, the researchers found. The findings could
point to new ways to prevent or treat the chronic brain inflammation linked to
cognitive disorders like Alzheimer's disease, autism and depression.

..........................

A Duke University study in rats finds that gut worms can protect babies'
brains from long-term learning and memory problems caused by newborn
infections.

Baby rats with tapeworms avoided the brain inflammation that plagued
worm-free rats after exposure to immune triggers in adulthood.

What's more, the benefits began early, while still in the womb. Expectant
mother rats with tapeworms passed similar protection on to their worm-free
pups, the researchers found.

The findings could point to new ways to treat or prevent the chronic brain
inflammation linked to cognitive disorders like Alzheimer's disease, autism and
depression.

The study appears online in the journal Brain, Behavior, and Immunity.

Previous studies by Duke neuroscientist Staci Bilbo and colleagues showed
that when rats get bacterial infections at a very early age, even elsewhere in
the body, immune cells in their brains become hypersensitive to subsequent
infections and pump out a continuous stream of messenger molecules called
cytokines that can cause cognitive problems later in life.

But for Bilbo, who is an associate professor of psychology and neuroscience
and a member of the Duke Institute for Brain Sciences, something didn't quite
add up. Given how frequently bacterial infections strike, it was still unclear
why a single infection at the wrong time would send the brain's immune cells
into permanent overdrive.

"We have faced bacterial infections throughout our entire evolutionary
history, presumably also during the neonatal period," Bilbo said. "It
always seemed kind of strange that the immune system would have evolved to
overreact like that."

That got Bilbo thinking. "Maybe this isn't how the immune system
evolved to work," she said.

According to what scientists call the "Biome Depletion Theory,"
some autoimmune and inflammation-related diseases may be the result of too few
of the life forms that once lived in and on the body -- particularly gut worms
-- rather than too many.

Tapeworms, roundworms and other wormy companions have inhabited the warm
wet folds of animal intestines for more than 100 million years, bathing in a
constant supply of food and nutrients.

Over millions of years of co-existence, the theory goes, the immune system
learned to tolerate these live-in guests, and eventually adapted to work with
worms in mind.

The theory is that now, with worms gone from our guts, the body's natural
defenses can spiral out of control.

"Our bodies are essentially an ecosystem," said Duke immunologist
and study co-author William Parker.

Parker and Bilbo decided to see if restoring the internal ecosystem in the
gut could bring the brain's immune cells back in balance.

Laboratory rats are ideal for testing the idea, Parker said, because the
life of a lab rat is a remarkably clean one.

Scientists started breeding strains of rodents for laboratory experiments
about 150 years ago. These animals are housed exclusively indoors, where their
cages and bedding are regularly disinfected. A series of pumps and fans change
the cage air more than a dozen times an hour. They eat processed food and sip
treated water, and take deworming drugs and antibiotics to keep them free of
parasites and pathogens.

"In a real sense we've done the same things to our lab animals that
we've inadvertently done to ourselves," Parker said.

The researchers did a first set of experiments comparing worm-free lab rats
with rats that were raised on a farm where they were exposed to worms. When
they infected the rats with bacteria, they found that the farm-raised rats
avoided the damaging overproduction of cytokine proteins linked to cognitive
decline later in life.

"We didn't see the same hyper immune response in the brain,"
Bilbo said.

Next, the researchers studied two groups of rats in the lab. One group
consisted of typical lab rats whose guts were worm-free. The other group was
identical in diet, housing, exercise and genetics to the first, except they --
and their parents before them -- were deliberately given tapeworms.

Both groups were injected with E. coli bacteria when the
rats were newborns. Once the pups reached adulthood they were given a second
injection, this time with a chemical from the cell walls of bacteria known to
spring the immune system into action.

The researchers then monitored changes in the rats' brains and behavior to
see how they responded to the one-two punch.

The worm-free rats responded to the second immune challenge with the same
harmful outpouring of inflammatory cytokines seen in previous studies.

But the wormy rats, and also rats that were worm-free but born to
worm-infested parents, responded differently.

Notably, the immune cells in their brains were able to respond to the
second trigger without going into overdrive. They also didn't develop the same
memory problems later in life that their worm-free counterparts did.

Next, the researchers hope to figure out whether before or sometime after
birth is the optimal time for treatment.

"Pregnancy is such an interesting time for the immune system,"
Bilbo said. "Maybe that's why it worked so well. We just don't know
yet."







Story Source:

The above post is reprinted from materials provided by Duke
University. Note: Materials may be edited for content and length.







Journal Reference:

1.   
Lauren L. Williamson, Erin A. McKenney, Zoie E. Holzknecht, Christine
Belliveau, John F. Rawls, Susan Poulton, William Parker, Staci D. Bilbo. Got
worms? Perinatal exposure to helminths prevents persistent immune sensitization
and cognitive dysfunction induced by early-life infection. Brain,
Behavior, and Immunity, 2015; DOI: 10.1016/j.bbi.2015.07.006

http://www.sciencedaily.com/releases/2015/07/150720145207.htm

Share this: