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Bagaimana membedakan antara gangguan bipolar , depresi
Date:
August 5, 2015
Source:
American Chemical Society
Summary:
Banyak pasien dengan gangguan bipolar , kondisi mental yang melemahkan yang dapat membuat orang dari kelesuan depresi parah hingga tingkat energi manusia super , sering salah didiagnosis sebagai memiliki gangguan depresi mayor , atau MDD . Tapi sekarang sebagai alternatif untuk ketergantungan pada wawancara pasien , para ilmuwan mendekati tes objektif yang dapat membantu dokter membedakan antara keduanya - dan memberikan pengobatan yang lebih baik .
..................... Untuk banyak alasan , gangguan bipolar umumnya keliru untuk MDD . Salah satu alasannya adalah bahwa kondisi sering pertama menjadi terlihat ketika pasien memiliki serangan depresi . Dan, sepertinya gangguan bipolar hanya mempengaruhi sekitar 1 persen dari populasi dunia , dokter kadang-kadang lupa untuk bertanya tentang hypomania , sebuah euforia , kondisi hiperaktif yang juga menjadi ciri khas kondisi . Teknik diagnostik saat ini melibatkan wawancara terstruktur dengan pasien , tetapi ini bisa menjadi subjektif dan menyesatkan . Diagnosis yang akurat , bagaimanapun, adalah penting untuk cepat mendapatkan pasien untuk perawatan yang mereka butuhkan . Jadi Peng Xie dan rekan memulai untuk mengembangkan cara yang obyektif untuk membedakan antara MDD dan gangguan bipolar .....more
How to tell the
difference between bipolar disorder, depression
Date:
August 5, 2015
Source:
American Chemical Society
Summary:
Many patients with bipolar disorder, a debilitating mental condition that
can take a person from the sluggishness of severe depression to super-human
energy levels, are often misdiagnosed as having major depressive disorder, or
MDD. But now as an alternative to reliance on patient interviews, scientists
are closing in on an objective test that could help clinicians distinguish between
the two -- and provide better treatment.
..........................
Many patients with bipolar disorder, a debilitating mental condition that
can take a person from the sluggishness of severe depression to super-human
energy levels, are often misdiagnosed as having major depressive disorder, or
MDD. But now as an alternative to reliance on patient interviews, scientists
are closing in on an objective test that could help clinicians distinguish
between the two -- and provide better treatment. Their method appears in ACS' Journal of Proteome Research.
For many reasons, bipolar disorder is commonly mistaken for MDD. One reason
is that the condition often first becomes noticeable when the patient has a
bout of depression. And, as bipolar disorder only affects about 1 percent of
the population worldwide, clinicians sometimes forget to ask about hypomania, a
euphoric, hyperactive state that also characterizes the condition. Current
diagnostic techniques involve structured interviews with patients, but these
can be subjective and misleading. An accurate diagnosis, however, is crucial to
quickly getting patients the treatment they need. So Peng Xie and colleagues
set out to develop an objective way to tell the difference between MDD and
bipolar disorder.
The researchers combined a couple of techniques -- gas chromatography-mass
spectrometry and nuclear magnetic resonance -- to analyze urine metabolites in
samples from patients who either had MDD or bipolar disorder. From these
results, they identified a panel of six biomarkers with an 89 to 91 percent
chance of predicting each disorder.
Story Source:
The above post is reprinted from materials provided byAmerican
Chemical Society. Note: Materials may be edited for content and length.
Journal Reference:
1.
Jian-jun Chen, Chan-juan Zhou, Zhao Liu, Yu-ying Fu, Peng Zheng, De-yu
Yang, Qi Li, Jun Mu, You-dong Wei, Jing-jing Zhou, Hua Huang, Peng Xie. Divergent
Urinary Metabolic Phenotypes between Major Depressive Disorder and Bipolar
Disorder Identified by a Combined GC–MS and NMR Spectroscopic Metabonomic
Approach. Journal of Proteome Research, 2015; 14 (8): 3382 DOI:10.1021/acs.jproteome.5b00434