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Mikroorganisme cystic fibrosis bertahan hidup dengan  sedikit atau tidak ada oksigen

Date:

July 28, 2015

Source:

American Society for Microbiology

Summary:

Mikroba kontribusi untuk cystic fibrosis yang mampu bertahan dalam air liur dan lendir yang secara kimiawi heterogen , termasuk bagian signifikan yang sebagian besar tanpa oksigen , menurut sebuah penelitian .

.................. Penelitian, yang mengevaluasi  sampel dahak dari 22 pasien CF pediatric , menemukan bahwa lingkungan mikrobiologis dapat berbeda antara pasien , dan bahkan dalam pasien yang sama pada titik-titik yang berbeda pada waktunya. Para peneliti juga mencatat bahwa sejumlah sampel mengandung hidrogen sulfida gas , bentuk sulfur yang bereaksi dengan dan menghilangkan  dari lingkungan . Pasien yang terdeteksi hidrogen sulfida dalam sputum mereka cenderung memiliki gejala penyakit yang lebih ringan ....more

Cystic fibrosis
microorganisms survive on little to no oxygen

Date:

July 28, 2015

Source:

American Society for Microbiology

Summary:

Microbes contributing to cystic fibrosis are able to survive in saliva and
mucus that is chemically heterogeneous, including significant portions that are
largely devoid of oxygen, according to a study.

...........................................................

Microbes contributing to cystic fibrosis (CF) are able to survive in saliva
and mucus that is chemically heterogeneous, including significant portions that
are largely devoid of oxygen, according to a study published this week in mBio®, the online open-access journal of the American Society for Microbiology.

The study, which evaluated sputum samples from 22 pediatric CF patients,
found that the microbiologic environment can differ between patients, and even
within the same patient at different points in time. Researchers also noted
that a number of samples contained the gas hydrogen sulfide, a form of sulfur that
reacts with and removes oxygen from the environment. Patients who had
detectable hydrogen sulfide in their sputum tended to have less severe disease
symptoms.

The findings shed a light on the conditions under which CF microbes can
survive, said senior study coauthor Dianne K. Newman, PhD, professor of biology
and geobiology at the California Institute of Technology, Pasadena, California.

"The diversity and adaptation of disease-causing microorganisms within
the CF lung environment, in part, is what renders CF infections so difficult to
eradicate," Newman said. "Few studies have attempted to characterize
the chemistry of mucus collecting in CF airways, yet such measurements are
essential if we are to understand how microorganisms survive in the lung and impact
the microenvironment."

For the study, researchers employed tools called microsensors, normally
used for environmental research, to measure high-resolution profiles of the
oxygen and sulfide levels of 48 fresh sputum samples from 22 pediatric CF patients
seen at Children's Hospital Los Angeles. They also looked at the samples'
chemistry and their oxidation-reduction potential, a measurement of an
environment's tendency to give or receive electrons. They found that the
samples had just a very thin layer of oxygen at the surface, but the bulk of
the samples were depleted of oxygen.

Of the samples profiled, 32 also were cultured for dominant CF
disease-causing microorganisms by the hospital's clinical microbiology
laboratory. Thirteen samples harboredPseudonomas aeruginosa, 12
had Staphylococus aureus, five were positive for both and two had
neither.

"We found oxygen only at the very narrow interface between the air and
samples," said senior study coauthor Wiebke Ziebis, PhD, associate
professor of biological sciences at the University of Southern California in
Los Angeles. "It's not only a stratified environment, with different
microbial communities at different depths of the sputum, but also temporarily
dynamic -- there were differences not only between patients but also at
different time points for the same patients."

Cystic fibrosis, which affects about 70,000 individuals worldwide, is a
genetic disorder that affects the cells that produce mucus, sweat and digestive
juices. These secretions are normally thin, but because of a defective gene, in
CF they become thick and sticky. People living with CF are susceptible to
chronic lung infection because of their inability to clear thickened mucus from
the airways.

Further study is needed to determine whether particular metabolic
fingerprints correlate with disease progression and, if so, which treatments
would be most effective under these conditions, the authors said. "A
greater diversity of metabolic survival strategies need to be considered and understood,
including ones that operate solely under no-oxygen conditions, because that
represents an important reservoir within this habitat," Newman said.







Story Source:

The above post is reprinted from materials provided byAmerican
Society for Microbiology. Note: Materials may be edited
for content and length.







Journal Reference:

1.   
Elise S. Cowley et al. Pediatric Cystic Fibrosis Sputum Can Be
Chemically Dynamic, Anoxic, and Extremely Reduced Due to Hydrogen Sulfide
Formation. mBio, July 2015 DOI: 10.1128/mBio.00767-15

http://www.sciencedaily.com/releases/2015/07/150728101204.htm

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